La pré-annotation automatique de textes cliniques comme support au dialogue avec les experts du domaine lors de la mise au point d'un schéma d'annotation

International audienceAutomatic text pre-annotation is an essential task that can facilitate the annotation of a text corpus. In the context of cardiology, manual text annotation is a complex task that requires in-depth domain knowledge and practical professional experience. Pre-annotating texts aims to reduce the time spent by experts on manual annotation and to focus their intervention on more critical aspects of annotation. We report here a pre-annotation experiment for clinical texts in cardiology : we present its modalities and the lessons learnt about our interaction with domain experts and on annotation schema design.La pré-annotation automatique de textes est une tâche essentielle qui peut faciliter l'annotationd'un corpus de textes. Dans le contexte de la cardiologie, l'annotation est une tâche complexe quinécessite des connaissances approfondies dans le domaine et une expérience pratique dans le métier.Pré-annoter les textes vise à diminuer le temps de sollicitation des experts, facilitant leur concentrationsur les aspects plus critiques de l'annotation. Nous rapportons ici une expérience de pré-annotationde textes cliniques en cardiologie : nous présentons ses modalités et les observations que nous enretirons sur l'interaction avec les experts du domaine et la mise au point du schéma d'a

La pré-annotation automatique de textes cliniques comme support au dialogue avec les experts du domaine lors de la mise au point d'un schéma d'annotation

International audienceAutomatic text pre-annotation is an essential task that can facilitate the annotation of a text corpus. In the context of cardiology, manual text annotation is a complex task that requires in-depth domain knowledge and practical professional experience. Pre-annotating texts aims to reduce the time spent by experts on manual annotation and to focus their intervention on more critical aspects of annotation. We report here a pre-annotation experiment for clinical texts in cardiology : we present its modalities and the lessons learnt about our interaction with domain experts and on annotation schema design.La pré-annotation automatique de textes est une tâche essentielle qui peut faciliter l'annotationd'un corpus de textes. Dans le contexte de la cardiologie, l'annotation est une tâche complexe quinécessite des connaissances approfondies dans le domaine et une expérience pratique dans le métier.Pré-annoter les textes vise à diminuer le temps de sollicitation des experts, facilitant leur concentrationsur les aspects plus critiques de l'annotation. Nous rapportons ici une expérience de pré-annotationde textes cliniques en cardiologie : nous présentons ses modalités et les observations que nous enretirons sur l'interaction avec les experts du domaine et la mise au point du schéma d'a

High-Dose Dexamethasone and Oxygen Support Strategies in Intensive Care Unit Patients With Severe COVID-19 Acute Hypoxemic Respiratory Failure

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The association between macrovascular complications and intensive care admission, invasive mechanical ventilation, and mortality in people with diabetes hospitalized for coronavirus disease-2019 (COVID-19)

International audienceAbstract Background It is not clear whether pre-existing macrovascular complications (ischemic heart disease, stroke or peripheral artery disease) are associated with health outcomes in people with diabetes mellitus hospitalized for COVID-19. Methods We conducted cohort studies of adults with pre-existing diabetes hospitalized for COVID-19 infection in the UK, France, and Spain during the early phase of the pandemic (between March 2020—October 2020). Logistic regression models adjusted for demographic factors and other comorbidities were used to determine associations between previous macrovascular disease and relevant clinical outcomes: mortality, intensive care unit (ICU) admission and use of invasive mechanical ventilation (IMV) during the hospitalization. Output from individual logistic regression models for each cohort was combined in a meta-analysis. Results Complete data were available for 4,106 (60.4%) individuals. Of these, 1,652 (40.2%) had any prior macrovascular disease of whom 28.5% of patients died. Mortality was higher for people with compared to those without previous macrovascular disease (37.7% vs 22.4%). The combined crude odds ratio (OR) for previous macrovascular disease and mortality for all four cohorts was 2.12 (95% CI 1.83–2.45 with an I 2 of 60%, reduced after adjustments for age, sex, type of diabetes, hypertension, microvascular disease, ethnicity, and BMI to adjusted OR 1.53 [95% CI 1.29–1.81]) for the three cohorts. Further analysis revealed that ischemic heart disease and cerebrovascular disease were the main contributors of adverse outcomes. However, proportions of people admitted to ICU (adjOR 0.48 [95% CI 0.31–0.75], I 2 60%) and the use of IMV during hospitalization (adjOR 0.52 [95% CI 0.40–0.68], I 2 37%) were significantly lower for people with previous macrovascular disease. Conclusions This large multinational study of people with diabetes mellitus hospitalized for COVID-19 demonstrates that previous macrovascular disease is associated with higher mortality and lower proportions admitted to ICU and treated with IMV during hospitalization suggesting selective admission criteria. Our findings highlight the importance correctly assess the prognosis and intensive monitoring in this high-risk group of patients and emphasize the need to design specific public health programs aimed to prevent SARS-CoV-2 infection in this subgroup