Redesigning Human Resource Management System through Cloud Computing: A Strategic Approach

Cloud computing is enabling human resource (HR) management functions to strategically integrate into business operations. Its acting as a game changer for HR amid intense competition to survive and grow. Digital disruption, transformation, agility has set the new benchmarks for organizations to automate and redesign their functions. Cloud Computing offers HR a completely new dimension with cloud centric benefits like reduction in communication gap, increased organizational excellence, effective talent strategies, data driven decision making, and supporting revenue in organizations. Cloud Computing has the right capability to redesign major HR functions with agility to match the changing requirements of business, automating transactional activities, smarter decision making and meeting the business expectations. Use of HR cloud in organization can result into structural benefits beyond technological advancements. Cloud HR gives organizations flexibility of location, prompt information processing, effective use of data analytics and strategic decision making. This paper discusses ways through which cloud computing could be integrated into HR functions. An analysis on applications of cloud computing in human resource areas with their outcomes is also presented in this paper. A brief note on future prospects of cloud computing in HRM is also discussed

Role of Various Mediators in Inflammation of Asthmatic Airways

The degree of airway inflammation is directly related to asthma severity and associated hyper-responsiveness. Airway inflammation is categorized into three types: (a) acute asthmatic inflammation featured by early recruitment of cells into the airways, (b) subacute asthmatic inflammation involving activation of recruited cells in continual inflammation, and (c) chronic inflammation characterized by cellular damage. T-helper lymphocytes, the key factor in the pathogenesis of bronchial asthma, induce B cells to synthesize and secrete IgE through production of IL-4 and induce eosinophil-mediated inflammation. Mediators such as histamine, PG, leukotrienes, and kinins contract airway smooth muscle, increase microvascular leakage, increase airway mucus secretion, and attract other inflammatory cells into airway epithelia that initiate mucociliary clearance signaling pathways through special Toll-like receptor 4 expressed on epithelial cells activated by allergic and infectious triggers. These cells form barrier against mechanical stress, oxidant stress, allergens, pollutants, infectious agents, and leakage of endogenous solutes. Various adhesion molecules and costimulatory factors also promote infiltration of inflammatory cells at the site of inflammation

Improving Physicochemical Properties of Repaglinide Through Pharmaceutical Adduct Formation

Background: Many formulation strategies are presently in development in pharmaceutical industry. However, the formation of pharmaceutical adducts is considered to be the most appropriate technique for improving the drug solubility and dissolution as no chemical bond changes are involved in this technique.Purpose: This technique is highly used for compounds which are not able to give viable formulation products with standard techniques such as salt formation and polymorph generation. In the present study, this method is applied to repaglinide, which is an hypoglycemic agent, with compromised solubility. Methods: The adducts were prepared by slow evaporation method and characterized using DSC, FTIR and PXRD studies. The solubility and dissolution studies were carried out to determine the increased solubility of drug in adducts. The drug amount interacted with coformers has also been determined. Results: The present study demonstrates the improvement in solubility and thus dissolution of repaglinide in adducts.Conclusion: The adducts formed in the present study can be further exploited to prepare formulation of repaglinide adducts with better physicochemical characteristics

Aesthetics of Poetry and Postmodernist Poets: A Review

Postmodernism is a period in which multiple modes or versions of different poetries exist and flourish. Poetry produced in the postmodern era and has an extremely solid nearness in cafes, bars, and even clubs, fundamentally outperforming its more conventional settings and areas. Poetry is becoming ever more synonymous with testing in English schools. poetry is not by learning the rules of scansion, or studying prosody and other theoretical aspects of poetry, although this is important, but by imitation. And what the poet imitates in the poets that he admires is the sound of the poetry, its rhythms, rhyme schemes, patterns, etc., not the lexical meanings of the words. Using the same words as the poets one admires would constitute plagiarism, not imitation, although one may certainly make allusions to other poems by means of what is sometimes called “poetic license”. poetry is cast as unstable and unreliable but simultaneously inescapable; language is both captor and captive .Poetry study at GCSE level could become a limited and controlled experience, restricted to the confines of the classroom and the pages of exam board anthologies.  In this work, we have studied a theory of different poets in view of the aesthetic content of poetry. These poets are exceptionally dynamic and their poetries are different from the theories of art and all other poetries. The industriousness of the expository strategies of aesthetic formalism close by the more up to date scholarly apparatuses of basic hypothesis and social feedback has been examined. They are very active, leading tertulias, engaging with poetry readings and performances in literary and non-literary circles, and endorsing verse on the internet, with the result that the genre is now more open and available to the general public than ever before. For the Transcendentalists all true poets are “children of music”.&nbsp

Performance Appraisal in the Era of New Normal

Performance Appraisal is the process of assessing the accomplishments of workforce & to ac­knowledge their capabilities for facilitating development. Performance evaluation is one of the areas in Human resource management which is considerably affected by the spread of pandemic severe acute respiratory syndrome corona virus 2. This virus outbreak posed new challenges for the companies across the globe. As a result in order to tackle this uncertainty various organiza­tions have taken measures to cut down the expenses like deferment in the appraisal cycle or for muted salary increments. Thus one of the objectives of this paper is to study the impact of Covid -19 on performance appraisal of employees. Further this pandemic is equally challenging for the managers also. As social distancing and working remotely have become a new normal, employees work remotely from each other and from managers, and this will be more common in the fu­ture. Managers are now searching for new ways to ‘do visibility’ without always being physically present. It has also become the vital demand of the situation as managers must be aware of the circumstances in which employees are working in. Therefore another objective of this paper is to suggest an approach to manage the performance evaluations of remote working employees. It is recommended that managers should adopt the choice based approach for performance evaluation instead of control based approach. The review is formed on articles and reports from various internet sources and journals. Further some ways of managing the performance assessment of remotely working employees and scope for the future are also discussed

PHYSICOCHEMICAL CHARACTERIZATION AND EVALUATION OF TELMISARTAN: HYDROXYPROPYL-β-CYCLODEXTRIN: TWEEN 80 INCLUSION COMPLEX

Objective: The present work was aimed to study the effect of the ternary component on complexation efficiency of cyclodextrins towards telmisartan which is a poorly soluble anti-hypertensive agent.Methods: The elucidation of inclusion complexation of telmisartan (TEL) with hydroxypropyl-β-cyclodextrin (HP-β-CD) in the presence and absence of tween 80 was done by investigating their interactions in solid and solution state. The solid state characterization was performed using differential scanning calorimetry (DSC), powder X-ray diffraction studies (PXRD) fourier transform infra-red spectroscopy (FTIR) studies. The host guest stoichiometry was confirmed in solution state by proton nuclear magnetic resonance (1HNMR) and solution calorimetry studies. The improvement in solubility was evaluated through dissolution studies, which was further confirmed by in vivo studies.Results: In solution state, the phase solubility studies indicated 1:1 stoichiometry between TEL and HP-β-CD both in presence and absence of tween 80. The NMR and molecular modelling studies indicated the insertion of N-methyl benzimidazole and biphenyl carboxylate regions of TEL into HP-β-CD cavity suggesting the coexistence of two 1:1 complexes in equilibrium with each other. The stability constants, K1 (imidazole region of TEL-CD) and K2 (biphenyl acetic acid region of TEL-CD), were enhanced in the presence of tween 80 as evident by the higher value of stability constants. Efficacy of ternary complex was established by a significant decrease in the systolic blood pressure of deoxycorticosterone acetate (DOCA) induced hypertensive rats.Conclusion: It can be concluded that solubility of TEL was increased by encapsulation with HP-β-CD. Tween 80 further increased the complexation efficiency and decreased the bulk of cyclodextrin

Bio-Functional Aspects of Grape Seeds-A Review

Grapes are one of the most widely consumed fruits all over the world and have considerable importance for their medicinal and nutritive value for thousand of years. Grapes are rich in polyphenols and 60-70 % of grapes polyphenols exist in grape seeds. The seeds contain lipid, proteins, carbohydrates and 5-8 % polyphenolic compounds. The phenolic compounds present in grape seeds are flavonoids including gallic acid, flavan-3-ol monomers and their oligomeric and polymeric derivatives (procyanidins). The most abundant flavan-3-ol monomers isolated from grape seeds are Catechin, epicatechin, epicatechin-3-O-gallate, and epigallocatechin-3-O-gallate. Three novel flavan oxidative derivatives named viniferones A, B and C have also been isolated from grape seeds. The grape seeds are chiefly known for their significant antioxidant properties. Scientific studies have claimed that the antioxidant potential of grape seeds proanthocyanidins is 20 times greater than vitamin E and 50 times greater than vitamin C. Grape seeds polyphenolic (Proanthocyanidin) extract have been marketed in France for decades as treatment for venous and capillary disorders (e.g., retinopathies, venous insufficiency, and vascular fragility. Recent studies have shown that procyanidins in grape seeds possess anti-inflammatory, anti-arthritic, anti-allergic effects and prevent heart diseases and skin aging. The high purity grape seed extract should contain polyphenols NLT 95% and monomers NLT 10%; and the grape seed extract with ordinary quality should have a procyanidolic value NLT 95%, and monomer NLT 6%.Keywords: Grapes, Grape seeds, Polyphenols, procyanidins, viniferones

ANTI-ANXIETY EVALUATION OF EXTRACTS OF STIGMA MAYDIS (CORN SILK)

Objective: The anxiolytic activity of petroleum ether, chloroform and ethyl acetate extracts of Stigma maydis was investigated by Elevated Plus Maze, Hole Board and Mirror Chamber Test.Methods: The study was conducted using elevated plus maze, whole board and mirror chamber test. Female Laca/Balb c was used to carry out the studies. In each experiment, animals were equally divided into five groups; control, given saline solution and Tween 80, standard given diazepam (2 mg/kg i. p.) and test groups were given 250, 500, 750 and 1000 mg/kg of petroleum ether, chloroform and ethyl acetate extracts of Stigma maydis. The data were subjected to analysis of variance by taking mean and standard error to the mean using Tukey's post-hoc test.Results: In Elevated Plus Maze chloroform extract (750 and 1000 mg/kg) of Stigma maydis revealed increase in time spent in open arm, frequency and preference to open arm as compared to control, which was almost comparable to diazepam. In Hole Board test decrease in number of head dips as compared to control was observed. In Mirror Chamber Test, the decrease in latency, increase in time spent in the mirror chamber and frequency as compared to control was observed. All of the changes were statistically highly significant.Conclusion: From our results it can be concluded that the chloroform extract of Stigma maydis showed anxiolytic activity at the dose of 750 and 1000 mg/kg.Â