3,868 research outputs found
The weld-brazing metal joining process
Superior mechanical properties were obtained in metal joints weld-brazed between faying surfaces. Weld-braze applications and advantages are listed
Weld-brazing - a new joining process
A joining process designated weld brazing which combines resistance spot welding and brazing has been developed. Resistance spot welding is used to position and align the parts as well as to establish a suitable faying surface gap for brazing. Fabrication is then completed by capillary flow of the braze alloy into the joint. The process has been used successfully to fabricate Ti-6Al-4V titanium alloy joints using 3003 aluminum braze alloy. Test results obtained on single overlap and hat-stiffened structural specimens show that weld brazed joints are superior in tensile shear, stress rupture, fatigue, and buckling than joint fabricated by spotwelding or brazing. Another attractive feature of the process is that the brazed joints is hermetically sealed by the braze material
A Multiscale Progressive Failure Modeling Methodology for Composites that Includes Fiber Strength Stochastics
A multiscale modeling methodology was developed for continuous fiber composites that incorporates a statistical distribution of fiber strengths into coupled multiscale micromechanics/finite element (FE) analyses. A modified two-parameter Weibull cumulative distribution function, which accounts for the effect of fiber length on the probability of failure, was used to characterize the statistical distribution of fiber strengths. A parametric study using the NASA Micromechanics Analysis Code with the Generalized Method of Cells (MAC/GMC) was performed to assess the effect of variable fiber strengths on local composite failure within a repeating unit cell (RUC) and subsequent global failure. The NASA code FEAMAC and the ABAQUS finite element solver were used to analyze the progressive failure of a unidirectional SCS-6/TIMETAL 21S metal matrix composite tensile dogbone specimen at 650 degC. Multiscale progressive failure analyses were performed to quantify the effect of spatially varying fiber strengths on the RUC-averaged and global stress-strain responses and failure. The ultimate composite strengths and distribution of failure locations (predominately within the gage section) reasonably matched the experimentally observed failure behavior. The predicted composite failure behavior suggests that use of macroscale models that exploit global geometric symmetries are inappropriate for cases where the actual distribution of local fiber strengths displays no such symmetries. This issue has not received much attention in the literature. Moreover, the model discretization at a specific length scale can have a profound effect on the computational costs associated with multiscale simulations.models that yield accurate yet tractable results
Consistent Treatment of Relativistic Effects in Electrodisintegration of the Deuteron
The influence of relativistic contributions to deuteron electrodisintegration
is systematically studied in various kinematic regions of energy and momentum
transfer. As theoretical framework the equation-of-motion and the unitarily
equivalent S-matrix approaches are used. In a (p/M)-expansion, all leading
order relativistic -exchange contributions consistent with the Bonn OBEPQ
model are included. In addition, static heavy meson exchange currents including
boost terms, -currents, and -isobar contributions
are considered. Sizeable effects from the various relativistic two-body
contributions, mainly from -exchange, have been found in inclusive form
factors and exclusive structure functions for a variety of kinematic regions.Comment: 41 pages revtex including 15 postscript figure
Decoupling of Massive Right-handed Neutrinos
We investigate the effect of B+L - violating anomalous generation of massive
right-handed neutrinos on their decoupling, when the right-handed neutrino mass
is considerably greater than the right-handed gauge boson masses. Considering
normal annihilation channels, the Lee-Weinberg type of calculation, in this
case, gives an upper bound of about 700 Gev, which casts doubt on the existence
of such a right-handed neutrino mass greater than right-handed gauge boson
masses. We examine the possibility that a consideration of anomalous effects
related to the SU(2)_R gauge group may turn this into a lower bound of the
order of 100 Tev.Comment: 28 Pages, Latex, 2 figure
Structure of HIV-1 reverse transcriptase in a complex with the non-nucleoside inhibitor α-APA R 95845 at 2.8 å resolution
AbstractBackground: HIV-1 reverse transcriptase (RT) is a multifunctional enzyme that copies the RNA genome of HIV-1 into DNA. It is a heterodimer composed of a 66 kDa (p66) and a 51 kDa (p51) subunit. HIV-1 RT is a crucial target for structure-based drug design, and potent inhibitors have been identified, whose efficacy, however, is limited by drug resistance.Results The crystal structure of HIV-1 RT in complex with the non-nucleoside inhibitor α-anilinophenylacetamide (α-APA) R 95845 has been determined at 2.8 å resolution. The inhibitor binds in a hydrophobic pocket near the polymerase active site. The pocket contains five aromatic amino acid residues and the interactions of the side chains of these residues with the aromatic rings of non-nucleoside inhibitors appear to be important for inhibitor binding. Most of the amino acid residues where mutations have been correlated with high levels of resistance to non-nucleoside inhibitors of HIV-1 RT are located close to α-APA. The overall fold of HIV-1 RT in complex with α-APA is similar to that found when in complex with nevirapine, another non-nucleoside inhibitor, but there are significant conformational changes relative to an HIV-1 RT/DNA/Fab complex.Conclusion The non-nucleoside inhibitor-binding pocket has a flexible structure whose mobility may be required for effective polymerization, and may be part of a hinge that permits relative movements of two subdomains of the p66 subunit denoted the ‘palm’ and ‘thumb’. An understanding of the structure of the inhibitor-binding pocket, of the interactions between HIV-1 RT and α-APA, and of the locations of mutations that confer resistance to inhibitors provides a basis for structure-based design of chemotherapeutic agents for the treatment of AIDS
Diet-Independent Remodeling of Cellular Membranes Precedes Seasonally Changing Body Temperature in a Hibernator
Polyunsaturated fatty acids (PUFA) have a multitude of health effects. Their incorporation into membrane phospholipids (PL) is generally believed to depend directly on dietary influx. PL influence transmembrane protein activity and thus can compensate temperature effects; e.g. PL n-6 PUFA are thought to stabilize heart function at low body temperature (Tb), whereas long chain (>C18) n-3 PUFA may boost oxidative capacity. We found substantial remodeling of membranes in free-living alpine marmots which was largely independent of direct dietary supply. Organ PL n-6 PUFA and n-6 to n-3 ratios were highest at onset and end of hibernation after rapid increases during a brief transitional period prior to hibernation. In contrast, longer chain PL n-3 PUFA content was low at end of summer but maximal at end of hibernation. After termination of hibernation in spring, these changes in PL composition were rapidly reversed. Our results demonstrate selective trafficking of PUFA within the body, probably governed by a circannual endogenous rhythm, as hibernating marmots were in winter burrows isolated for seven months from food and external cues signaling the approaching spring. High concentrations of PL n-6 PUFA throughout hibernation are in line with their hypothesized function of boosting SERCA 2a activity at low Tb. Furthermore, we found increasing rate of rewarming from torpor during winter indicating increasing oxidative capacity that could be explained by the accumulation of long-chain PL n-3 PUFA. It may serve to minimize the time necessary for rewarming despite the increasing temperature range to be covered, because rewarming is a period of highest metabolic rate and hence production of reactive oxygen species. Considering the importance of PUFA for health our results may have important biomedical implications, as seasonal changes of Tb and associated remodeling of membranes are not restricted to hibernators but presumably common among endothermic organisms
Femtometer Toroidal Structures in Nuclei
The two-nucleon density distributions in states with isospin , spin
=1 and projection =0 and 1 are studied in H, He,
Li and O. The equidensity surfaces for =0 distributions are
found to be toroidal in shape, while those of =1 have dumbbell shapes
at large density. The dumbbell shapes are generated by rotating tori. The
toroidal shapes indicate that the tensor correlations have near maximal
strength at fm in all these nuclei. They provide new insights and simple
explanations of the structure and electromagnetic form factors of the deuteron,
the quasi-deuteron model, and the , and =2 (-wave)
components in He, He and Li. The toroidal distribution has a
maximum-density diameter of 1 fm and a half-maximum density thickness of
0.9 fm. Many realistic models of nuclear forces predict these values,
which are supported by the observed electromagnetic form factors of the
deuteron, and also predicted by classical Skyrme effective Lagrangians, related
to QCD in the limit of infinite colors. Due to the rather small size of this
structure, it could have a revealing relation to certain aspects of QCD.Comment: 35 pages in REVTeX, 25 PostScript figure
Algebraic approach in the study of time-dependent nonlinear integrable systems: Case of the singular oscillator
The classical and the quantal problem of a particle interacting in
one-dimension with an external time-dependent quadratic potential and a
constant inverse square potential is studied from the Lie-algebraic point of
view. The integrability of this system is established by evaluating the exact
invariant closely related to the Lewis and Riesenfeld invariant for the
time-dependent harmonic oscillator. We study extensively the special and
interesting case of a kicked quadratic potential from which we derive a new
integrable, nonlinear, area preserving, two-dimensional map which may, for
instance, be used in numerical algorithms that integrate the
Calogero-Sutherland-Moser Hamiltonian. The dynamics, both classical and
quantal, is studied via the time-evolution operator which we evaluate using a
recent method of integrating the quantum Liouville-Bloch equations \cite{rau}.
The results show the exact one-to-one correspondence between the classical and
the quantal dynamics. Our analysis also sheds light on the connection between
properties of the SU(1,1) algebra and that of simple dynamical systems.Comment: 17 pages, 4 figures, Accepted in PR
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