Toward a Principled Approach to the Distribution of Global Wealth: An Impartial Solution to the Dispute over Seabed Manganese Nodules

This Article discusses the major economic and political conflicts that underlie the seabed dispute over the allocation of seabed manganese nodules. The author argues that none of the interests groups have presented a compelling legal position, and urges the conferees to distribute manganese nodules according to a rigorously defined impartial scheme. The author argues that such action will provide the impartial legal precedent urgently required to avoid more serious conflicts over the distribution of global wealth

Impaired Nuclear Export of Polyglutamine-Expanded Androgen Receptor in Spinal and Bulbar Muscular Atrophy.

Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease caused by polyglutamine (polyQ) expansion in the androgen receptor (AR). Prior studies have highlighted the importance of AR nuclear localization in SBMA pathogenesis; therefore, in this study, we sought to determine the role of AR nuclear export in the pathological manifestations of SBMA. We demonstrate here that the nuclear export of polyQ-expanded AR is impaired, even prior to the formation of intranuclear inclusions of aggregated AR. Additionally, we find that promoting AR export with an exogenous nuclear export signal substantially reduces its aggregation and blocks hormone-induced toxicity. Moreover, we show that these protective effects are conferred by destabilization of the mutant protein due to an increase in proteasomal degradation of the cytoplasmic AR. Despite a growing body of evidence that global disruption of nucleo/cytoplasmic transport occurs in ALS and HD, our data suggest that no such global disruption occurs in models of SBMA; rather, AR-specific mechanisms, including reduced phosphorylation at Serine 650, are likely responsible for the impaired nuclear export of polyQ-expanded AR

Studies of magnetic effects of ICl

Ph.D.William H. Eberhard

The Philosophy of Composition

D.ring the slow and regular development of the human race from infancy to adolescence and from adolescence to old age, the one question confronting it is the quiddity of its environment. One of the most prominent of man\u27s characteristics is to seek knowledge; to learn something new; to know what was hitherto unknown and through this knowledge to gain further enlightenment upon things about him. He has studied the planets and the elements; he has made note of the physical and chemical laws but has me:rely attempted to gain an adequate knowledge of himself

A Measure of Perceived Power in Influencing Change among Selected Education Participants in Alberta

The educational landscape in the province of Alberta is undergoing change. The government\u27s agenda includes changes in funding, reducing the number of school jurisdictions and local school boards, the provincial appointment of superintendents, increasing school-based decision making and accountability, and increasing parent, community, and business involvement in the delivery of education. It is expected that these changes will be completed during 1997. Considering the climate of change in Alberta education, it is of paramount importance that in the implementation process, participants in the change recognize their personal power to operationalize what is proposed. Government legislation can demand compliance, but without the commitment of Alberta trustees, superintendents, principals, and school advisory council presidents, change in education may remain on paper only. Power, defined as the capacity to knowingly participate in change, provides the theoretical basis for the assessment of the perceived power in influencing change among Alberta trustees, superintendents, principals, and school advisory council presidents. The synergistic interrelation of the concepts of awareness, choice, freedom to act intentionally, and involvement in creating change constitutes the theory of power whereby human beings participate in the innovative creation of their reality. Assessing the degree of knowing participation in change of the groups selected may serve as an indicator of their commitment to change in the province of Alberta. The results of the study indicated that school advisory council presidents had the most perceived power, followed by principals and trustees. Superintendents felt the least power. The personal variables of age and gender influenced the awareness and choice of trustees. Female trustees were more aware of education change and recognized more choices than did male trustees. Older trustees felt more freedom to act intentionally than did their younger counterparts. The study also indicated that female principals were more aware of change than male principals. The institutional variables influencing the perceived power of the groups studied were size, type of jurisdiction, and position. Trustees in smaller jurisdictions felt less power than trustees in larger jurisdictions. Trustees in divisions felt less power than those in districts. School advisory council presidents felt more powerful in terms of choice than did superintendents

Through The Ages

https://digitalcommons.library.umaine.edu/mmb-vp/6429/thumbnail.jp

Effect of arsenic on assay for gold and silver

In presenting the within thesis, it is not claimed by the authors that the experiments have been, by any means, exhaustive of the subject. Neither is any claim made to original research work other than a series of simple experiments with a view to determining, if possible, some of the more important effects of Arsenic upon a fire assay for gold and silver as met with in the ordinary assay laboratory. To make a work complete and exhaustive on such a subject will require much more time and more complete apparatus than was available in the experiments covered by this thesis. The experiments have been intended to cover both fusion by crucible, and cupellation, as well as the wet assay of slags, cupels and lead buttons. Briefly stated, the problem presented in this paper is to locate the sources of loss in a fire assay for gold and silver, due to the impurity, Arsenic, and its compounds, and to ascertain, if possible, the remedy for those losses. The solution of the problem is proposed by means of the scheme outlined in the following flow sheet:- --Page 1

Abandoned Railroads in Maine: Their Potential for Trail Use

Abandoned railroads in Maine : their potential for trail use / prepared by Arnold S. Biondi, Frederick W. Lyman for the Maine Department of Parks & Recreation, Planning & Research Division This report, conceived as part of an in-depth analysis of existing and potential trail facilities in Maine, attempts to provide some concrete information and recommendations as the first step in the realization of a Statewide railroad right-of- way trail system.https://digitalcommons.usm.maine.edu/me_collection/1014/thumbnail.jp