Post-Flight Evaluation of Stardust PICA Forebody Heatshield Material

This presentation was part of the session : Sample Return ChallengesSixth International Planetary Probe WorkshopPhenolic Impregnated Carbon Ablator (PICA) was developed at NASA Ames Research Center under the lightweight ceramic ablator development program in the '80s. PICA has the advantages of low density (~ 0.27g/cc) coupled with efficient ablative capability at high heat fluxes making PICA an enabling technology for the Stardust mission. Three cores at key locations were extracted from the forebody heatshield of the Stardust Sample Return Capsule (SRC) post flight and evaluated. Core locations include a near stagnation core, a flank core and a segment taken from the shoulder of the heatshield. Evaluation included density profiles, recession determination, thermal analysis profile, PICA bondline examination, strength of remaining virgin PICA, emissivity profile, chemical analysis profile and microstructural analysis. Comparisons between experimental density profiles and profiles derived from FIAT, a tool used to predict ablative performance, are in good agreement. Recession comparisons from measured values and FIAT predictions are currently being obtained. In addition a laser scanning tool developed at ARC is being used to evaluate recession measurements and compare to experimental and predicted values. In general, the PICA material examined in the cores is in good condition and intact. Impact damage is not evident and the main degradation observed was that caused by heating on entry. A substantial amount of "virgin" PICA was present in all cores examined. It is noted that the post-flight analysis of the Stardust heat shield is especially important since PICA is baselined for both the Orion (CEV) and Mars Science Laboratory vehicles.NASA; NESC; Orion Thermal Protection System Advanced Development Projec

A Role for Myosin VI in the Localization of Axonal Proteins

In neurons polarized trafficking of vesicle-bound membrane proteins gives rise to the distinct molecular composition and functional properties of axons and dendrites. Despite their central role in shaping neuronal form and function, surprisingly little is known about the molecular processes that mediate polarized targeting of neuronal proteins. Recently, the plus-end-directed motor Myosin Va was shown to play a critical role in targeting of transmembrane proteins to dendrites; however, the role of myosin motors in axonal targeting is unknown. Here we show that Myosin VI, a minus-end-directed motor, plays a vital role in the enrichment of proteins on the surface of axons. Engineering non-neuronal proteins to interact with Myosin VI causes them to become highly concentrated at the axonal surface in dissociated rat cortical neurons. Furthermore, disruption of either Myosin VI function or expression leads to aberrant dendritic localization of axonal proteins. Myosin VI mediates the enrichment of proteins on the axonal surface at least in part by stimulating dendrite-specific endocytosis, a mechanism that has been shown to underlie the localization of many axonal proteins. In addition, a version of Channelrhodopsin 2 that was engineered to bind to Myosin VI is concentrated at the surface of the axon of cortical neurons in mice in vivo, suggesting that it could be a useful tool for probing circuit structure and function. Together, our results indicate that myosins help shape the polarized distributions of both axonal and dendritic proteins

Blister Beetles of Oklahoma

The Oklahoma Agricultural Experiment Station periodically issues revisions to its publications. The most current edition is made available. For access to an earlier edition, if available for this title, please contact the Oklahoma State University Library Archives by email at [email protected] or by phone at 405-744-6311

Overview of Economic Development

Economic development is a vast concept with an abundance of meanings depending upon the audience. A widely accepted view of economic development is as follows: In the United States with our market economy focus, economic development typically centers on increasing private business activity as a way to increase new investment, job creation and tax base expansion. Economies and economic development should serve the needs of residents and society through the creation of meaningful work. (RUPRI Center for Rural Entrepreneurship, 2005) Historically, rehabilitation worked to restore as much lost function as possible so that a person with a disability could engage what was seen as a stable, unchanging world. More recently, the new paradigm of disability emphasizes that disability is a natural part of the human experience and that people with disabilities shouldn’t be treated as separate, as special, or as a commodity. With this change disability researchers, practitioners, and advocates recognize that disability occurs when the environment presents barriers to people’s participation in the community. In the disability context, environment is understood as the communities in which we live. This new view challenges our understanding of the place human diversity plays within a community and the degree to which community ecology is designed to accommodate participation in economic and civic life–aspects of the environment that can be modified to accommodate the goals of people with a variety of functional limitations. Although rural America is their home, living there can place those who experience disability at a disadvantage. Compared to their urban counterparts, rural Americans with disabilities experience higher rates of poverty, higher unemployment, and poorer health. One strategy for addressing these issues for rural residents is economic development

Storage and Supports Have Worked, But...

Storage and supports have worked, but what would have happened without them in the 1952-58 period? Farm p rices and incomes would have dropped, say these authors. Withholding grain did have the effect of raising prices and incomes in this period. But is it possible we\u27ve only borrowed this increase from the future

Beneficial insects

The Oklahoma Cooperative Extension Service periodically issues revisions to its publications. The most current edition is made available. For access to an earlier edition, if available for this title, please contact the Oklahoma State University Library Archives by email at [email protected] or by phone at 405-744-6311

O-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein associated with Parkinson's disease.

Several aggregation-prone proteins associated with neurodegenerative diseases can be modified by O-linked N-acetyl-glucosamine (O-GlcNAc) in vivo. One of these proteins, α-synuclein, is a toxic aggregating protein associated with synucleinopathies, including Parkinson's disease. However, the effect of O-GlcNAcylation on α-synuclein is not clear. Here, we use synthetic protein chemistry to generate both unmodified α-synuclein and α-synuclein bearing a site-specific O-GlcNAc modification at the physiologically relevant threonine residue 72. We show that this single modification has a notable and substoichiometric inhibitory effect on α-synuclein aggregation, while not affecting the membrane binding or bending properties of α-synuclein. O-GlcNAcylation is also shown to affect the phosphorylation of α-synuclein in vitro and block the toxicity of α-synuclein that was exogenously added to cells in culture. These results suggest that increasing O-GlcNAcylation may slow the progression of synucleinopathies and further support a general function for O-GlcNAc in preventing protein aggregation

Pentatomoidea (Hemiptera) of Oklahoma

The Oklahoma Agricultural Experiment Station periodically issues revisions to its publications. The most current edition is made available. For access to an earlier edition, if available for this title, please contact the Oklahoma State University Library Archives by email at [email protected] or by phone at 405-744-6311