3 research outputs found

    Review: The Newsletter and Journal of Dramaturgy, volume 19, issue 1

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    Contents include: Save the Date! 2009 LMDA Annual Conference Washington, D.C. July 16-19, 2009; Out of Bounds, Conference planner Danielle Mages Amato and LMDA President Shelley Orr share ideas in development for the next conference; Developing Digiturgy, An early career dramaturg explores the uses of wikimedia while working on a production of A midsummer Night\u27s Dream; I\u27d Rather Shove a Bodkin in My Nowl or Wear a Bona Roba\u27s Merkin Than Be That Kind of Dramaturg, A Dramaturgical Manifesta; The Better Part of Valour, In Residence as Master of Verse at Richmond Shakespeare Festival; Theatre, Tears, and Rock, Dramaturging The Onion Cellar at the American Repertory Theatre Issue editors: D.J. Hopkins, Lauren Beckhttps://soundideas.pugetsound.edu/lmdareview/1038/thumbnail.jp

    Review: The Newsletter and Journal of Dramaturgy, volume 18, issue 1

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    Contents include: Celebrating a Coffee Klatch; The Toronto Dialogues, A Conversation on US Airways Flight 4081 from Toronto to Philadelphia, June 24th, 2007; The 2008 Elliott Hayes Award, Edward Sobel\u27s Acceptance Speech at the LMDA Annual Conference Toronto, 23 June 2007; Neighborhood Stories Toronto, 2007; Parliament Street; Provocative Dramaturgy The Collaborative Creation of The Re:Actions Project; ECD Special Careers in Dramaturgy, The Writer\u27s Advocate: An Interview with Abrams Artists Agency\u27s Beth Blickers. Issue editors: D.J. Hopkins, Shelley Orrhttps://soundideas.pugetsound.edu/lmdareview/1036/thumbnail.jp

    Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

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    SummaryBackground Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatoryactions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19.Methods In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospitalwith COVID-19 in the UK. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients wererandomly allocated to either usual standard of care alone or usual standard of care plus azithromycin 500 mg once perday by mouth or intravenously for 10 days or until discharge (or allocation to one of the other RECOVERY treatmentgroups). Patients were assigned via web-based simple (unstratified) randomisation with allocation concealment andwere twice as likely to be randomly assigned to usual care than to any of the active treatment groups. Participants andlocal study staff were not masked to the allocated treatment, but all others involved in the trial were masked to theoutcome data during the trial. The primary outcome was 28-day all-cause mortality, assessed in the intention-to-treatpopulation. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936.Findings Between April 7 and Nov 27, 2020, of 16 442 patients enrolled in the RECOVERY trial, 9433 (57%) wereeligible and 7763 were included in the assessment of azithromycin. The mean age of these study participants was65·3 years (SD 15·7) and approximately a third were women (2944 [38%] of 7763). 2582 patients were randomlyallocated to receive azithromycin and 5181 patients were randomly allocated to usual care alone. Overall,561 (22%) patients allocated to azithromycin and 1162 (22%) patients allocated to usual care died within 28 days(rate ratio 0·97, 95% CI 0·87–1·07; p=0·50). No significant difference was seen in duration of hospital stay (median10 days [IQR 5 to >28] vs 11 days [5 to >28]) or the proportion of patients discharged from hospital alive within 28 days(rate ratio 1·04, 95% CI 0·98–1·10; p=0·19). Among those not on invasive mechanical ventilation at baseline, nosignificant difference was seen in the proportion meeting the composite endpoint of invasive mechanical ventilationor death (risk ratio 0·95, 95% CI 0·87–1·03; p=0·24).Interpretation In patients admitted to hospital with COVID-19, azithromycin did not improve survival or otherprespecified clinical outcomes. Azithromycin use in patients admitted to hospital with COVID-19 should be restrictedto patients in whom there is a clear antimicrobial indication
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