148 research outputs found

    Description of plasma penicillin G concentrations after intramuscular injection in double-muscled cows to optimize the timing of antibiotherapy for Caesarean section

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    In order to improve the efficacy of penicillin injection during caesarean section, we aimed to identify the optimal timing of its preoperative administration. A study was conducted in 12 adult, non-pregnant Belgian Blue cows. To evaluate the plasma penicillin concentrations, blood samples were taken from the jugular vein at −5, 15, 30, 45, 60, 120, 240, 480 min relative to the intramuscular (IM) injection of 21,000 IU/kg of body weight of penicillin G. Results showed that plasma concentrations at 15 min after IM injection (668.3 ± 73.7 ng/mL) largely exceeded the minimal inhibitory concentration (MIC) of penicillin-sensitive bacteria (MIC &lt; 125 ng/mL). With increasing time, plasma concentrations continued to rise, attaining an increasing proportion of moderately sensitive bacteria (250 ng/mL &gt; MIC &lt; 2000 ng/mL). The maximal concentration was reached between 1 and 4 h (average: 1.495.1 ± 181.7 ng/mL) after IM injection in the majority of cows, and decreased non-significantly to 1002.1 ± 93.2 ng/mL at 8 h. In conclusion, plasma penicillin concentrations at 15 min after an IM injection inhibit penicillin-sensitive bacteria. However, in order to obtain the maximal protective effect of the antibiotherapy, surgery should be started at 1 to 2 h after IM penicillin injection.</jats:p

    Parietal fibrinous peritonitis in cattle: A literature review

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    peer reviewedBackground: Parietal fibrinous peritonitis (PFP) is a complication of laparotomy in cattle, consisting of fluid and fibrin accumulation within a fibrous capsule between the parietal peritoneum and the abdominal muscles. Since scientific information on PFP is scarce, we aim to collect available information to help practitioners in its diagnosis and treatment, and to formulate research perspectives. Methods: PubMed and GoogleScholar databases were scanned using “cattle” or “bovine”, and one of the following keywords: “seroma”, “parietal fibrinous peritonitis”, “retroperitoneal abscess”, or “wound infection”. Results: Although scientific information is often anecdotal, two recent larger studies shed more light on PFP symptoms, diagnosis and treatment. Symptoms vary according to the cavity’s localisation and size, and include anorexia, weight loss and an inflammatory status. Rectal palpation is strongly indicative, but the definitive diagnosis is made by ultrasound. Trueperella pyogenes and Escherichia coli are frequently isolated germs, although it remains unclear whether they are primary or secondary agents. Good survival rates were reported after surgical drainage. Conclusion: Although the diagnosis and treatment seem clear, the exact pathogenesis of PFP should be the focus of ongoing research. This can be achieved by epidemiological data analysis focusing on risk factors like surgery technique, housing and ration

    An obstructive upper respiratory emergency in a pregnant Belgian blue heifer

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    peer reviewedIn this case report, the surgical intervention and aftercare are described of an upper airway obstruction in a two-and-a-half year old, seven-months pregnant Belgian blue heifer. The animal had been referred to the Clinic for Ruminants (University of Liège) for complaints of stridor and dyspnea and suffered from necrotic laryngitis, complicated by the formation of an obstructive granuloma. Emergency tracheotomy was performed to save the life of the cow and its calf. Through the use of a self-retaining cannula, the modified tracheotomy site could be kept patent until the calf was born and the pathology resolved two months after admission. Healing of the larynx was checked and documented by use of nasal and retro-tracheal endoscopy
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