Dynamics of Protoplanetary Disks

Protoplanetary disks are quasi-steady structures whose evolution and dispersal determine the environment for planet formation. I review the theory of protoplanetary disk evolution and its connection to observations. Substantial progress has been made in elucidating the physics of potential angular momentum transport processes - including self-gravity, magnetorotational instability, baroclinic instabilities, and magnetic braking - and in developing testable models for disk dispersal via photoevaporation. The relative importance of these processes depends upon the initial mass, size and magnetization of the disk, and subsequently on its opacity, ionization state, and external irradiation. Disk dynamics is therefore coupled to star formation, pre-main-sequence stellar evolution, and dust coagulation during the early stages of planet formation, and may vary dramatically from star to star. The importance of validating theoretical models is emphasized, with the key observations being those that probe disk structure on the scales, between 1 AU and 10 AU, where theory is most uncertain.Comment: Annual Review of Astronomy and Astrophysics (2011). Final edited version at http://www.annualreviews.org/doi/abs/10.1146/annurev-astro-081710-102521 .High resolution versions of illustrations at http://jila.colorado.edu/~pja/araa.htm

The challenges and issues of undergraduate student retention and attainment in UK veterinary medical education

Student retention and attainment has recently been identified as a key area for development in veterinary medical education enquiry. Woodfield's research on retention and attainment across the UK disciplines has yielded some unique information about the challenges and issues of students who study veterinary medicine and related subjects. The present literature review aims to expand on Woodfield's findings and explain important issues about retention and attainment across veterinary medicine. Overall, the subject of retention and attainment in undergraduate veterinary medical education needs a great deal more empirical attention, such as data on the retention and attainment of mature and widening access students, and the effects of students being placed at remote locations during their studies. Our findings also cover some unsurprising issues: the dominance of women in a profession that is principally lead by men, the underrepresentation of black and minority ethnic (BME) students in veterinary medicine, and the effects of content overload in the veterinary medical curriculum. Based on data gathered by Woodfield and our investigation of the scholarly and gray literatures, we offer an overview of gaps in current knowledge and recommendations for further research

The effects of tidally induced disc structure on white dwarf accretion in intermediate polars

We investigate the effects of tidally induced asymmetric disc structure on accretion onto the white dwarf in intermediate polars. Using numerical simulation, we show that it is possible for tidally induced spiral waves to propagate sufficiently far into the disc of an intermediate polar that accretion onto the central white dwarf could be modulated as a result. We suggest that accretion from the resulting asymmetric inner disc may contribute to the observed X-ray and optical periodicities in the light curves of these systems. In contrast to the stream-fed accretion model for these periodicities, the tidal picture predicts that modulation can exist even for systems with weaker magnetic fields where the magnetospheric radius is smaller than the radius of periastron of the mass transfer stream. We also predict that additional periodic components should exist in the emission from low mass ratio intermediate polars displaying superhumps.Comment: 9 pages, 5 figures, accepted for publication in MNRA

Resonant state expansion applied to planar waveguides

The resonant state expansion, a recently developed method in electrodynamics, is generalized here to planar open optical systems with non-normal incidence of light. The method is illustrated and verified on exactly solvable examples, such as a dielectric slab and a Bragg reflector microcavity, for which explicit analytic formulas are developed. This comparison demonstrates the accuracy and convergence of the method. Interestingly, the spectral analysis of a dielectric slab in terms of resonant states reveals an influence of waveguide modes in the transmission. These modes, which on resonance do not couple to external light, surprisingly do couple to external light for off-resonant excitation

Modeling chemotaxis reveals the role of reversed phosphotransfer and a bi-functional kinase-phosphatase

Understanding how multiple signals are integrated in living cells to produce a balanced response is a major challenge in biology. Two-component signal transduction pathways, such as bacterial chemotaxis, comprise histidine protein kinases (HPKs) and response regulators (RRs). These are used to sense and respond to changes in the environment. Rhodobacter sphaeroides has a complex chemosensory network with two signaling clusters, each containing a HPK, CheA. Here we demonstrate, using a mathematical model, how the outputs of the two signaling clusters may be integrated. We use our mathematical model supported by experimental data to predict that: (1) the main RR controlling flagellar rotation, CheY6, aided by its specific phosphatase, the bifunctional kinase CheA3, acts as a phosphate sink for the other RRs; and (2) a phosphorelay pathway involving CheB2 connects the cytoplasmic cluster kinase CheA3 with the polar localised kinase CheA2, and allows CheA3-P to phosphorylate non-cognate chemotaxis RRs. These two mechanisms enable the bifunctional kinase/phosphatase activity of CheA3 to integrate and tune the sensory output of each signaling cluster to produce a balanced response. The signal integration mechanisms identified here may be widely used by other bacteria, since like R. sphaeroides, over 50% of chemotactic bacteria have multiple cheA homologues and need to integrate signals from different sources

Diverse Diversions:Youth Justice Reform, Localized Practices, and a ‘New Interventionist Diversion’?

The recent resurgence of practices aimed at ‘diverting’ young people from prosecution appears to suggest a sea change from the interventionism which characterized New Labour’s approach to young law-breakers. Drawing on interviews with youth justice practitioners at two sites in England, we argue this is overly simplistic, since the ‘interventionist diversion’ they describe reflects the continued influence of New Labour reforms, as well as older approaches. We conclude that more empirical research is needed to establish where such interventions sit within the broader – and increasingly localized – landscape of support provision, as well as the consequences of providing ‘welfare’ in this way. </jats:p

Clinical trial of FK 506 immunosuppression in adult cardiac transplantation

The new immunosuppressive agent FK 506 was used as primary immunotherapy in conjunction with low-dose steroids and azathioprine in 72 patients subsequent to orthotopic cardiac transplantation. Overall patient survival at a mean follow-up of 360 days was 92%. The number of episodes of cardiac rejection (grade 3A or greater) within 90 days of transplantation was 0.95 per patient. The actuarial freedom from rejection at 90 days was 41%. Achievement of this level of immunosuppression is comparable with that of cyclosporine-based triple-drug therapy with OKT3 immunoprophylaxis. Thirty percent of patients were tapered off all steroids, and the average steroid dose in the group who received steroids was 8.6 mg of prednisone per day. The incidence of infection reflected the diminished necessity for steroids: seven major infections (10%) and 11 minor infections (16%). Renal dysfunction occurred during the perioperative period in most patients in this trial. However, the incidence of hypertension was 54% compared with 70% during the cyclosporine era. Ten adults underwent successful rescue therapy with FK 506 after cardiac rejection refractory to conventional immunotherapy. Side effects of FK 506 were notably few, and the results of the trial are encouraging for the future of the cardiac transplant recipient. © 1992

Gauss Sums and Quantum Mechanics

By adapting Feynman's sum over paths method to a quantum mechanical system whose phase space is a torus, a new proof of the Landsberg-Schaar identity for quadratic Gauss sums is given. In contrast to existing non-elementary proofs, which use infinite sums and a limiting process or contour integration, only finite sums are involved. The toroidal nature of the classical phase space leads to discrete position and momentum, and hence discrete time. The corresponding `path integrals' are finite sums whose normalisations are derived and which are shown to intertwine cyclicity and discreteness to give a finite version of Kelvin's method of images.Comment: 14 pages, LaTe