23 research outputs found
Additional file 3: of A phase II trial comparing pazopanib with doxorubicin as first-line treatment in elderly patients with metastatic or advanced soft tissue sarcoma (EPAZ): study protocol for a randomized controlled trial
List of all ethical bodies that approved the EPAZ study. (DOCX 14 kb
Additional file 1: of Non-invasive diagnosis of acute rejection in renal transplant patients using mass spectrometry of urine samples - a multicentre phase 3 diagnostic accuracy study
Quality Assurance/Monitoring. (DOC 31 kb
Individual values of muscle sympathetic nerve activity (burst frequency in bursts/min) measured after clean air and ozone exposure at rest (top), at the end of maximum inspiratory apnea (middle) and during late phase II of the Valsalva maneuver (bottom) for subjects exposed first to clean air (empty circles, n = 4) and for subjects exposed first to ozone (filled circles, n = 7).
<p>Individual values of muscle sympathetic nerve activity (burst
frequency in bursts/min) measured after clean air and ozone exposure at
rest (top), at the end of maximum inspiratory apnea (middle) and during
late phase II of the Valsalva maneuver (bottom) for subjects exposed
first to clean air (empty circles, n = 4) and for
subjects exposed first to ozone (filled circles,
n = 7).</p
Differential cell count in induced sputum at baseline and the exposure effect adjusted for period 6 hours after the start of exposure to ozone compared to clean air.
<p>Mean ± SEM, n = 14, CI confidence limits,
g = gram, perc  =  per
cent, cells/g  =  cells/gram, neutros
 =  neutrophil granulocytes, macros
 =  macrophages, eos  = 
eosinophil granulocytes, lymphos  = 
lymphocytes, epis  =  epithelial cells.</p
Characteristics of the study population.
<p>Shown are either absolute frequencies and percentages or means and
standard deviations.</p
Heart rate variability (HRV), blood pressure variability (BPV) and baroreflex sensitivity (BRS) data measured on both study days at rest and during deep breathing.
<p>mean values ± SEM, TP =  total power, LF
 =  low frequency, HF  = 
high frequency, LF/HF  =  LF to HF ratio,
LF-SBP  =  Low frequency power of systolic
blood pressure variability, BRSup  = 
baroreflex sensitivity calculated by the sequence technique for
increasing blood pressure, BRSdown  = 
baroreflex sensitivity calculated by the sequence technique for
decreasing blood pressure, BRSLF =  baroreflex
sensitivity calculated by cross spectral analysis in the low
frequency band, BRSHF =  baroreflex sensitivity
calculated by cross spectral analysis in the high frequency
band.</p
Muscle sympathetic nerve activity (burst frequency, burst incidence and area under the burst) measured on both study days at rest, during deep breathing (6 breaths per minute), at the end of the maximum voluntary inspiratory breath hold maneuver (end apnea) and during late phase II of the Valsalva maneuver.
<p>mean values ± SEM (n = 11), MSNA
 =  muscle sympathetic nerve activity.</p
Examples of integrated muscle sympathetic nerve activity recorded at about 19–22 hours after exposure to clean air or to ozone in two subjects.
<p>Examples of integrated muscle sympathetic nerve activity recorded at
about 19–22 hours after exposure to clean air or to ozone in two
subjects.</p
Port025-2017-0814-BancaPDM
aGerman unit costs according to Bock et al. [19]. bIndirect costs only for subjects of employable age < 65 years. cWork absence only for full-time and regular part-time employees. (DOC 40 kb
Additional file 1: Table S1. of Assessing health-related quality of life in COPD: comparing generic and disease-specific instruments with focus on comorbidities
Correlations between HRQL instruments and with GOLD grade and BODE as clinical measures: Spearman Correlation Coefficients. Table S2. Adjusted mean EQ-5D utilities, EQ-5D VAS, CAT score, SGRQ total scores for COPD grade 1–4 stratified for group with low (≤3) or high (>3) number of comorbidities. Table S3. Results of regression models considering interactions between COPD grades and low/high number of comorbidity. Figure S1. Lifetime prevalence of self-reported comorbidities (%) in the study population. Figure S2. HRQL scores by FEV1 % pred.: non-parametric quantile regression: quantile fit plots for FEV1 % pred. (DOC 258 kb