Vision of Healthy Lifestyle for Women of Older Generation

Period of active longevity is caused by a large number of biological and social factors, determined by the genetic structure of an organism and its adaptive reactions to external and internal behavioral factors. Elderly persons lifestyle to the full extent can be related to external factors. At this age the style of life has a great influence on health, and consequently, on the quality of life. It is possible to live a healthy lifestyle only on condition that a person has a general concept of its components. This general concept can be changed during some period of time. The concept depends on persons social status in society, and includes moral, cultural and social norms, values and ideals. It also includes age, sex, standard of living, education and residency in the district, city (town) where there are facilities to realise the motor function. In order to study social background of keeping a healthy lifestyle, the survey of women of older generation, who attend health clubs has been conducted. The urgent character of this problem is caused by the fact that in modern sociocultural environment researches of healthy lifestyle are held on schoolchildren, students and middle aged people. There are few researches which characterise the concept of healthy lifestyle of people of older generation. The introduced experimental material confirms the urgent character of the problem. The algorithm of evaluation of the relevance of the factors that characterise the healthy lifestyle had been developed. Concepts of women of the older generation, who attend health groups are represented.Период активного долголетия обусловлен большим количеством биологических и социальных условий, определяемых наследственной структурой организма и адаптивными реакциями организма к внешним и поведенческим факторам. К внешним факторам в полной мере можно отнести образ жизни пожилого человека. В этом возрасте образ жизни оказывает особое влияние на состояние здоровья, а значит и на качество жизни. Вести здоровый образ жизни возможно только при наличии определенных представлений о его составляющих. Эти представления со временем меняются, зависят от социального статуса человека в обществе, включают нравственные, культурные, социальные нормы, ценности и идеалы; возраст, пол, уровень жизни, образованность, место жительства в масштабе района, города, где есть условия для реализации двигательной активности. С целью изучения социальных предпосылок к ведению здорового образа жизни проведено целенаправленное анкетирование женщин старшего поколения, занимающихся в группах здоровья. Актуальность данной проблемы обусловлена тем, что в современной социокультурной среде исследования по вопросам здорового образа жизни направлены на школьный, студенческий, средний возраст и практически отсутствуют работы, характеризующие представления об образе жизни людей старшего поколения. Представленный экспериментальный материал подтверждает актуальность проблемы. Разработан алгоритм оценки значимости факторов, характеризующих здоровый образ жизни. Исследованы представления женщин старшего поколения, занимающихся в группах здоровья о критериях здорового образа жизни

Vision of Healthy Lifestyle for Women of Older Generation

Period of active longevity is caused by a large number of biological and social factors, determined by the genetic structure of an organism and its adaptive reactions to external and internal behavioral factors. Elderly persons lifestyle to the full extent can be related to external factors. At this age the style of life has a great influence on health, and consequently, on the quality of life. It is possible to live a healthy lifestyle only on condition that a person has a general concept of its components. This general concept can be changed during some period of time. The concept depends on persons social status in society, and includes moral, cultural and social norms, values and ideals. It also includes age, sex, standard of living, education and residency in the district, city (town) where there are facilities to realise the motor function. In order to study social background of keeping a healthy lifestyle, the survey of women of older generation, who attend health clubs has been conducted. The urgent character of this problem is caused by the fact that in modern sociocultural environment researches of healthy lifestyle are held on schoolchildren, students and middle aged people. There are few researches which characterise the concept of healthy lifestyle of people of older generation. The introduced experimental material confirms the urgent character of the problem. The algorithm of evaluation of the relevance of the factors that characterise the healthy lifestyle had been developed. Concepts of women of the older generation, who attend health groups are represented.Период активного долголетия обусловлен большим количеством биологических и социальных условий, определяемых наследственной структурой организма и адаптивными реакциями организма к внешним и поведенческим факторам. К внешним факторам в полной мере можно отнести образ жизни пожилого человека. В этом возрасте образ жизни оказывает особое влияние на состояние здоровья, а значит и на качество жизни. Вести здоровый образ жизни возможно только при наличии определенных представлений о его составляющих. Эти представления со временем меняются, зависят от социального статуса человека в обществе, включают нравственные, культурные, социальные нормы, ценности и идеалы; возраст, пол, уровень жизни, образованность, место жительства в масштабе района, города, где есть условия для реализации двигательной активности. С целью изучения социальных предпосылок к ведению здорового образа жизни проведено целенаправленное анкетирование женщин старшего поколения, занимающихся в группах здоровья. Актуальность данной проблемы обусловлена тем, что в современной социокультурной среде исследования по вопросам здорового образа жизни направлены на школьный, студенческий, средний возраст и практически отсутствуют работы, характеризующие представления об образе жизни людей старшего поколения. Представленный экспериментальный материал подтверждает актуальность проблемы. Разработан алгоритм оценки значимости факторов, характеризующих здоровый образ жизни. Исследованы представления женщин старшего поколения, занимающихся в группах здоровья о критериях здорового образа жизни

Glutamate Transporter Inhibitors with Photo-Controlled Activity

Glutamate is an important signaling molecule in the nervous system and its extracellular levels are regulated by amino acid transporters. Studies on the role of glutamate transport have benefitted from the development of small molecule inhibitors. Most inhibitors, however, cannot be remotely controlled with respect to the time and place of their action, which limits their application in biological studies. Herein, the development and evaluation of inhibitors of the prokaryotic transporter GltTk with photo‐controlled activity, enabling the remote, reversible, and spatiotemporally resolved regulation of transport is reported. Based on a known inhibitor, seven inhibitors, bearing a photoswitchable azobenzene moiety, are designed and synthesized. The most promising photo‐controlled inhibitor, shows in its non‐irradiated form, an IC50 of 2.5 ± 0.4 μm for transport by GltTk. Photoswitching results in a reversible drop of potency to an IC50 of 9.1 ± 1.5 μm. This 3.6‐fold difference in activity is used to demonstrate that the transporter function can be switched on and off reversibly through irradiation. As a result, this inhibitor could be a powerful tool in studying the role of glutamate transport by precisely controlling the time, and the specific tissue or groups of cells, in which the inhibitor is active

Glutamate Transporter Inhibitors with Photo-Controlled Activity

Glutamate is an important signaling molecule in the nervous system and its extracellular levels are regulated by amino acid transporters. Studies on the role of glutamate transport have benefitted from the development of small molecule inhibitors. Most inhibitors, however, cannot be remotely controlled with respect to the time and place of their action, which limits their application in biological studies. Herein, the development and evaluation of inhibitors of the prokaryotic transporter GltTk with photo‐controlled activity, enabling the remote, reversible, and spatiotemporally resolved regulation of transport is reported. Based on a known inhibitor, seven inhibitors, bearing a photoswitchable azobenzene moiety, are designed and synthesized. The most promising photo‐controlled inhibitor, shows in its non‐irradiated form, an IC50 of 2.5 ± 0.4 μm for transport by GltTk. Photoswitching results in a reversible drop of potency to an IC50 of 9.1 ± 1.5 μm. This 3.6‐fold difference in activity is used to demonstrate that the transporter function can be switched on and off reversibly through irradiation. As a result, this inhibitor could be a powerful tool in studying the role of glutamate transport by precisely controlling the time, and the specific tissue or groups of cells, in which the inhibitor is active