PERBEDAAN PROFIL LIPID, PERSENTASE LEMAK TUBUH, DAN LINGKAR PINGGANG PADA WANITA USIA SUBUR AKSEPTOR KB SUNTIK DEPO MEDROKSI PROGESTERON ASETAT DENGAN NON AKSEPTOR KB DI KOTA PADANG

PERBEDAAN PROFIL LIPID, PERSENTASE LEMAK TUBUH, DAN LINGKAR PINGGANG PADA WANITA USIA SUBUR AKSEPTOR KB SUNTIK DEPO MEDROKSI PROGESTERON ASETAT DENGAN NON AKSEPTOR KB DI KOTA PADANG ABSTRAK Kontrasepsi hormonal yang dianggap cukup ideal adalah kontrasepsi suntik Depo Medroksi Progesteron Asetat (DMPA). Banyaknya akseptor yang memilih kontrasepsi ini dikarenakan kontrasepsi ini bersifat aman, efektif, serta dapat digunakan pasca persalinan. Perlu diwaspadai kemungkinan efek samping yang dapat terjadi, khususnya terhadap profil lipid, persentase lemak tubuh, indeks massa tubuh, dan lingkar pinggang. Tujuan penelitian ini yaitu untuk melihat perbedaan profil lipid, persentase lemak tubuh, indeks massa tubuh, dan lingkar pinggang pada wanita usia subur akseptor KB suntik DMPA dan non akseptor KB. Penelitian ini bersifat observasional dengan pendekatan Cross Sectional Comparative dan dilakukan di UPTD Laboratorium Kesehatan Daerah Provinsi Sumatera Barat (Labkesda) dari bulan Desember 2017 sampai Juni 2018. Sampel penelitian yaitu 46 akseptor DMPA dan 46 non akseptor KB. Pengambilan sampel dilakukan dengan teknik simple random sampling. Pemeriksaan dengan metode enzimatis kolorimetri yaitu GPO-PAP untuk trigliserida, dan CHOD-PAP untuk kolesterol total, HDL dan LDL. Untuk pemeriksaan persentase lemak menggunakan Bioelectrical Impedance Analysis (BIA). Data dianalisis menggunakan uji t – independent dan data yang tidak normal dengan uji non parametric Mann – whitney dengan nilai p < 0.05 dianggap terdapat perbedaan bermakna secara statistik. Hasil Penelitian menunjukkan terdapat perbedaan yang bermakna antara akseptor KB DMPA dan non akseptor KB (p 0,05). Kesimpulan penelitian ini adalah terdapat perbedaan yang bermakna pada kolesterol total, LDL, trigliserida, persentase lemak, indeks massa tubuh, dan lingkar pinggang antara akseptor KB DMPA dengan non akseptor KB, pada HDL tidak terdapat perbedaan yang bermakna antara akseptor KB DMPA dengan non akseptor KB. Kata Kunci : Profil Lipid, Persentase Lemak, Lingkar Pinggang, DMP

EFFORTS USING LEARNING MODEL COOPERATIVE INTEGRATED READING AND COMPOSITION (CIRC) TO IMPROVE STUDENTS ACTIVENESS ON COURSE ASKEB I (PREGNANCY) IN PRODI DIII MIDWIFERY STIKES MINANG PADANG 2015

In the course Askeb I (Pregnancy) Academic Year 2013/2014 , in which 112 students on subjects Askeb I which has a value of A and B is at least 35 people (31.25%) . This illustrates clearly that 68.75% of the students in the course Askeb I have a level of understanding that is only limited by graduation . The researchers used an alternative model of learning that can improve student learning activities in the course Askeb I (pregnancy) through a cooperative learning model CIRC aimed at improving student learning activeness in Prodi DIII Midwifery STIKes Minang Padang 2015 .This research is a classroom action research (classroom action research) undertaken by researchers directly , which is done by 3 cycles . Each cycle consists of four activities namely : planning, action , observation , and reflection . Samples were students Prodi DIII Midwifery STIKes Minang Padang in 2015 the number of students 11 people . An instruments using documentation , questionnaire , and observation .Based on the results of learning activities of students in the first cycle (56.36%) medium category , in the second cycle (65.45%) medium category , and the third cycle (89.08%) higher category . It can be concluded that the use of cooperative learning model CIRC can improve student learning activities .The researchers suggest to lecturers to use cooperative learning model CIRC one alternative for further learning in other subjects such as Askeb III , Askeb V , Documentation Obstetrics , and Reproductive Health , to improve the learning activities of students and can be submitted as reference and consideration of reference for subsequent studie

Differences of lipid profile, body fat percentage, and waist circumference between childbearing age women acceptors of depot medroxy progesterone acetate contraceptive injection with non-acceptors in Padang City 2017

Background: A hormonal contraception which considered ideal is depot medroxy progesteron acetat. There are large number of acceptors choose this contraception because this contraception is considered safe, effective, and can be used after labor. The possible side effect which can occur are increase of lipid profile, body fat percentage, and waist circumference. The purpose of this study is to see the differences between lipid profile, body fat percentage, and the waist circumference of women of childbearing age who use depot medroxy progesteron acetat injection compared with non-acceptors.Methods: This study was observational study with a cross sectional comparative approach and was conducted at the Regional Technical Services Unit (UPTD) at Regional Health Laboratory in West Sumatera Province from December 2017 until June 2018. The samples were 46 DMPA acceptors and 46 non-acceptors. The sampling method used random sampling technique. The measurements of lipid profile was conducted with colorimetric enzymatic method, which is GPO-PAP for triglycerides, and CHOD-PAP for total cholesterol, HDL and LDL. The percentage of body fat examination was conducted using Bioelectrical Impedance Analysis (BIA). The obtained data were analyzed by using t-test. Abnormal data were confirmed by Mann-whitney non-parametric test with p0.05). There were significant differences in total cholesterol, LDL, triglycerides, fat percentage, body mass index, and the circumference of waist in both DMPA acceptors and non acceptors. There were no significant difference in HDL levels between DMPA acceptors and non acceptors.Conclusions: There were significant differences in total cholesterol, LDL, triglycerides, fat percentage, body mass index, and waist circumference between DMPA acceptors and non-acceptors. There was no significant difference in HDL between DMPA acceptors and non-acceptors

A novel interaction between a 23-SNP genetic risk score and monounsaturated fatty acid intake on HbA1c levels in Southeast Asian women

Metabolic diseases result from interactions between genetic and lifestyle factors. Understanding the combined influences of single-nucleotide polymorphisms (SNPs) and lifestyle is crucial. This study employs genetic risk scores (GRS) to assess SNPs, providing insight beyond single gene/SNP studies by revealing synergistic effects. Here, we aim to investigate the association of a 23-SNP GRS with metabolic disease-related traits (obesity and type 2 diabetes) to understand if these associations are altered by lifestyle/dietary factors. For this study, 106 Minangkabau women were included and underwent physical, anthropometric, biochemical, dietary and genetic evaluations. The interaction of GRS with lifestyle factors was analyzed using linear regression models, adjusting for potential confounders. No statistically significant associations were observed between GRS and metabolic traits; however, this study demonstrates a novel interaction observed between 13-SNP GRS and monounsaturated fatty acid (MUFA) intake, and that it had an effect on HbA1c levels (p = 0.026). Minangkabau women with low MUFA intake (≤7.0 g/day) and &gt;13 risk alleles had significantly higher HbA1c levels (p = 0.010). This finding has implications for public health, suggesting the need for large-scale studies to confirm our results before implementing dietary interventions in the Indonesian population. Identifying genetic influences on dietary response can inform personalized nutrition strategies to reduce the risk of metabolic disease

Interaction between Vitamin D-related genetic risk score and carbohydrate intake on body fat composition: a study in Southeast Asian Minangkabau women

Metabolic diseases have been shown to be associated with low vitamin D status; however, the findings have been inconsistent. Hence, the objective of our study was to investigate the relationship between vitamin D status and metabolic disease-related traits in healthy Southeast Asian women and examine whether this relationship was modified by dietary factors using a nutrigenetic study. The study included 110 Minangkabau women (age: 25–60 years) from Padang, Indonesia. Genetic risk scores (GRS) were constructed based on five vitamin D-related single nucleotide polymorphisms (SNPs) (vitamin D-GRS) and ten metabolic disease-associated SNPs (metabolic-GRS). The metabolic-GRS was significantly associated with lower 25-hydroxyvitamin D (25(OH)D) concentrations (p = 0.009) and higher body mass index (BMI) (p = 0.016). Even though the vitamin D-GRS had no effect on metabolic traits (p > 0.12), an interaction was observed between the vitamin D-GRS and carbohydrate intake (g) on body fat percentage (BFP) (pinteraction = 0.049), where those individuals who consumed a high carbohydrate diet (mean ± SD: 319 g/d ± 46) and carried >2 vitamin D-lowering risk alleles had significantly higher BFP (p = 0.016). In summary, we have replicated the association of metabolic-GRS with higher BMI and lower 25(OH)D concentrations and identified a novel interaction between vitamin D-GRS and carbohydrate intake on body fat composition