CLINICAL-AUDIOLOGICAL CHARACTERISTICS OF OTOSCLEROSIS

To study the clinical course and audiological characteristics of otosclerosis. There were analyzed the clinical-audiological data of 238 patients with otosclerosis referred to the Department of Otorhinolaryngology of TashPMI for the period from May 2015 to January 2018. The diagnosis of otosclerosis and its form was made according to patient’s complaints, anamnesis, clinical course, otomicroscopy data, acoustic examination, tonal audiometry, acoustic impedancemetry, MSCT of temporal bones. In all 238 patients, otosclerosis was confirmed during surgical intervention. Results: Otosclerosis was detected among otological patients in 8.7% of cases. The duration of the disease before referral was from 1 year to 30 years. Most often, the first signs of the disease appeared at the age of 21-40 years (50%). The largest number of patients referred with otosclerosis belonged to the age group of 31 to 40 years - 50%. The tympanal form of otosclerosis was noted in 45.9% of patients, the mixed form - in 48.8% and the cochlear form - in 5.1% of patients

Quantum Interference Effects in Slowly Rotating NUT Space-time

General relativistic quantum interference effects in the slowly rotating NUT space-time as the Sagnac effect and the phase shift effect of interfering particle in neutron interferometer are considered. It was found that in the case of the Sagnac effect the influence of NUT parameter is becoming important due to the fact that the angular velocity of the locally non rotating observer must be larger than one in the Kerr space-time. In the case of neutron interferometry it is found that due to the presence of NUT-parameter an additional term in the phase shift of interfering particle emerges. This term can be, in principle, detected by sensitive interferometer and derived results can be further used in experiments to detect the gravitomagnetic charge. Finally, as an example, we apply the obtained results to the calculation of the UCN (ultra-cold neutrons) energy level modification in the slowly rotating NUT space-time.Comment: 11 pages, 1 figure, accepted for publication in Int. J. Mod. Phys. D; added reference

The condition of the vegetative nervous system and methods of correction of its changes in patients with seasonal allergic rhinitis

Allergic diseases represent a major public health problem worldwide. The frequency of allergic rhinitis in the general population is 10-20%, 68% of which is seasonal allergic rhinitis. In 57.14% of patients with seasonal allergic rhinitis, initial vagotonia combined with predominantly over-provisioning activity of the hyperdiastolic type was found. According to the severity of the course of exacerbation of seasonal allergic rhinitis 18,25% had mild course, 57,94% - medium severity of course and 23,81% - severe course of the disease. Application of corrective vegetotropic therapy allows to increase the effectiveness of treatment of seasonal allergic rhinitis exacerbation in vagotonics (57,14% ) in 1,21 times in terms of total clinical effectiveness and in 1,64 times in terms of clinical recovery of patients with seasonal allergic rhinitis. The average increase in the effectiveness of complex treatment of seasonal allergic rhinitis including vagotonia correction is 1.42 times

Population of isomers in decay of the giant dipole resonance

The value of an isomeric ratio (IR) in N=81 isotones ($^{137}$Ba, $^{139}$Ce, $^{141}$Nd and $^{143}$Sm) is studied by means of the ($\gamma, n)$ reaction. This quantity measures a probability to populate the isomeric state in respect to the ground state population. In ($\gamma, n)$ reactions, the giant dipole resonance (GDR) is excited and after its decay by a neutron emission, the nucleus has an excitation energy of a few MeV. The forthcoming $\gamma$ decay by direct or cascade transitions deexcites the nucleus into an isomeric or ground state. It has been observed experimentally that the IR for $^{137}$Ba and $^{139}$Ce equals about 0.13 while in two heavier isotones it is even less than half the size. To explain this effect, the structure of the excited states in the energy region up to 6.5 MeV has been calculated within the Quasiparticle Phonon Model. Many states are found connected to the ground and isomeric states by $E1$, $E2$ and $M1$ transitions. The single-particle component of the wave function is responsible for the large values of the transitions. The calculated value of the isomeric ratio is in very good agreement with the experimental data for all isotones. A slightly different value of maximum energy with which the nuclei rest after neutron decay of the GDR is responsible for the reported effect of the A-dependence of the IR.Comment: 16 pages, 4 Fig

ENDOTHELIAL AND INFLAMMATORY FACTORS IN THE PATHOGENESIS OF LIMITED AND SYSTEMIC SCLERODERMA

Objective: to study the relationship of factors of endothelial dysfunction and inflammatory process in the skin in patients with various forms of diabetes. Material and methods: The work is based on the analysis of skin biopsies in 64 patients, including 29 patients with SSD and 35 patients with LSD, and 20 healthy volunteers aged 16 to 60 years. Duration of the diabetes in patients was from 6 to 20 years (13.5 ± 5.2 years). Diagnosis of diabetes was verified using diagnostic criteria proposed by A.G. Guseva. Bioptates in patients with diabetes were taken with the affected and unaffected pathological process of the skin. In healthy volunteers, the skin for examination was taken with surgical correction of cosmetic defects. In the supernatant, the concentration of CRP, TNF-α, endothelin-1 (ET-1) was determined by the enzyme immunoassay, NO level, endothelial nitric oxide synthase (eNOS) activity, inducible nitroxide synthase (iNOS). The data was processed using the “SPSS for Windows” software using the method of comparative correlation and One-Way ANOVA analyzes using the Dunnett test for multiple comparison. The results for P \u3c0.05 were considered reliable. Results: In patients with diabetes, depending on the form of the disease in the biopsy supernatant, a different level of concentration of hsCRP and TNF-α, the content of NO, ONO2-, the activity of eNOS and iNOS is determined. These systems are interrelated. In patients with SSD, the concentration of hsCRP and TNF-α, as well as disturbances in the parameters of the NO-producing skin function, are statistically significantly higher, compared with patients with OSD. Conclusions: hsCRP and TNF-α stimulate the expression of iNOS, which in turn increases the production of NO and ONO2-, inhibits the activity of eNOS, determining the peculiarity of pathomorphological changes in the skin and the shape of diabetes