Distributions of Allocated Sticker Charts in Two Subsamples.

<p>Distributions of Allocated Sticker Charts in Two Subsamples.</p

The effect of AVPR1A RS3 ‘target allele’ on allocations in the DG.

<p>Percentage of children according to the number of sticker charts allocated in the DG (0, 1 or 2 and more), and the presence/absence of the ‘target allele’. Compared with non carriers, carriers are much less likely to allocate more than 2 sticker charts, and more likely to allocate nothing.</p

Frequencies of AVPR1A RS3 Promoter Region Repeat Alleles, in a Sample of 136 Twins and 162 Parents.

<p>Frequencies of AVPR1A RS3 Promoter Region Repeat Alleles, in a Sample of 136 Twins and 162 Parents.</p

Mean maternal sensitivity based on risk at birth and the presence/absence of maternal DRD4-III 7-repeat allele.

<p>Mean levels (and standard errors) of observed maternal sensitivity as a function of child risk at birth (low, medium, and high) and the presence or absence of maternal DRD4-7R allele. Mothers who are non-carriers of the 7 allele showed no difference in levels of sensitivity under conditions of high, medium, and low risk at birth. Mothers who are carriers of the 7 allele were more sensitive to low-risk children and less sensitive to high-risk children.</p

Means and Standard Deviations of Study Variables by the Presence and Absence of Maternal DRD4-III 7-Repeat Allele.

<p>Means and Standard Deviations of Study Variables by the Presence and Absence of Maternal DRD4-III 7-Repeat Allele.</p

Correlations between Risk at Birth and Maternal Behavior as a Function of the Presence/Absence of Maternal DRD4-III 7-Repeat Allele.

<p>*<i>p</i><.05;</p><p>**<i>p</i><.01, 1-tailed.</p

Salivary cortisol levels following the TSST.

<p>Area under the curve following the TSST for males and females. The rise in salivary cortisol is significant (SPSS GLM repeated measures) for men (F = 22.32 p<0.001) and for females (F = 9.04 p<0.001).</p

Methylation levels of the GR exon 1F and NFGI-A CpG #12 by gender.

<p>Percentage methylation levels of exon 1F (A) and NFGI-A CpG #12 (B) for males and females.</p

Methylation levels across 39 CpG sites in exon 1F for each subject.

<p>Methylation level of GR exon 1F at individual CpG sites for females (n = 46) (2A) and males (n = 46) (2B). Each point in the figure represents a single individual's percentage methylation value for each of the 39 CpG sites that were analyzed by bisulfite pyrosequencing. The points were color coded by the graph option in Excel and each color and shape represents an individual subject. The graph illustrates the marked individual differences (indicated by the shape and color of markers) in percentage methylation at each CpG site. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0048597#pone-0048597-g002" target="_blank">Figure (2C</a>) presents the promoter sequence of exon 1F showing the CpG sites and their position. Highlighted regions represent known or putative canonical (italics) and noncanonical (not italics) NGFI-A–binding sites, with the shaded grey area indicating the beginning of the exon (following McGowan et al (23)).</p

GR exon 1F methylation and total cortisol output.

<p>Correlation between AUC and average percent methylation at GR exon 1F in female subjects.</p