Classifier model based on decision trees.

<p>Decision nodes are represented by circles. Decision nodes show the significant variables used to perform the classification: EP-METRN (METRN levels in early pregnancy), MP-SBP (systolic blood pressure in middle pregnancy), MP-Weight (weight in middle pregnancy), ∆Weight (delta of weight between middle and early pregnancy: ∆Weight = MP.weight–EP.weight) and ∆SBP (Delta of Systolic Blood Pressure between middle and early pregnancy: ∆SBP = MP.SBP–EP.SBP). Each branch represents a test given to the decision node. Leaf nodes are represented by squares. Leaf nodes show the class in which a patient is classified (normal or preeclampsia). Leaf nodes also show the total of women from the cohort that were properly classified / total of women from the cohort misclassified.</p

Anthropometric and biochemical characteristics of healthy non—pregnant women.

<p>^a The difference between group means (early follicular and median luteal phases) was tested on progesterone and METRN levels. Only progesterone levels are significantly different between early follicular and median luteal phases (p<0.0001). Data with normal distribution were reported as mean +/- standard deviation (SD), while data with non-normal distribution were reported as median and interquartile range (IQR).</p><p>^b Progesterone determination in the two different phases of the menstrual cycle.</p><p>^c Meteorin measurement in luteal and follicular phase.</p><p>Anthropometric and biochemical characteristics of healthy non—pregnant women.</p

METRN immunohistochemisty in human placenta.

<p>Human placenta in the first trimester of pregnancy (spontaneous abortion) in which immature mesenchymal villi of first trimester decidua are illustrated. Moderate cytoplasmic immunoreactivity for METRN was observed in cytotrophoblast cells, syncytiotrophoblast cells and decidual cells (20x). A non-specific rabbit IgG was used as negative control in place of the primary polyclonal rabbit anti-METRN antibody in each immunohistochemistry placental specimen.</p