A Rare Presentation of Mycosis Fungoides Mimicking Psoriasis Vulgaris

Mycosis fungoides (MF) is an uncommon primary cutaneous lymphoma with a wide spectrum of clinicopathological manifestations. Diagnosis can be difficult in its early stages given the considerable overlap with more common benign dermatoses. We report an unusual case of MF in a 52-year-old male presenting with psoriasiform plaques on the palms and the soles who rapidly developed additional lesions on the scalp, limps and trunk. Punch biopsy of the face was obtained for routine histology and immunohistochemical stains. Chest X-ray, total body computed tomography scanning and excisional biopsy of the inguinal lymph node were performed. Review of the face biopsy revealed a diffuse dermal infiltrate containing a high number of atypical lymphocytes showing a CD3+, CD4+, CD45RO+, CD8–, CD20– immunophenotype and epidermotropism. Findings were consistent with tumor stage MF (stage IIB, T3 N1 M0). We report a rare presentation of MF mimicking psoriasis vulgaris

Response to 'No evidence of SARS-CoV-2 infection by polymerase chain reaction or serology in children with pseudo-chilblain'. Reply from the authors

Dear Editor, Recalcati et al. conclude that chilblain-like lesions (CLLs) are part of the spectrum of COVID-19 based on reports of SARS-CoV-2 in endothelial cells of skin biopsies assessed by immunohistochemistry and electron microscopy (EM).1 Nevertheless, the conclusion does not seem to be adequately supported by the data. Recalcati et al. expand their previously reported case series to include 32 patients with CLLs. In 21 of 32 cases, no nasopharyngeal swab (NPS) was tested for SARS-CoV-2. Two of 11 patients subjected to molecular testing were positive for SARS-CoV-2, but no serological test was performed to verify the seroconversion. Three patients tested positive for IgM and negative for IgG antibodies without any confirmation of infection through NPS

Neurophysiological Profile of Antismoking Campaigns

Over the past few decades, antismoking public service announcements (PSAs) have been used by governments to promote healthy behaviours in citizens, for instance, against drinking before the drive and against smoke. Effectiveness of such PSAs has been suggested especially for young persons. By now, PSAs efficacy is still mainly assessed through traditional methods (questionnaires and metrics) and could be performed only after the PSAs broadcasting, leading to waste of economic resources and time in the case of Ineffective PSAs. One possible countermeasure to such ineffective use of PSAs could be promoted by the evaluation of the cerebral reaction to the PSA of particular segments of population (e.g., old, young, and heavy smokers). In addition, it is crucial to gather such cerebral activity in front of PSAs that have been assessed to be effective against smoke (Effective PSAs), comparing results to the cerebral reactions to PSAs that have been certified to be not effective (Ineffective PSAs). &e eventual differences between the cerebral responses toward the two PSA groups will provide crucial information about the possible outcome of new PSAs before to its broadcasting. &is study focused on adult population, by investigating the cerebral reaction to the vision of different PSA images, which have already been shown to be Effective and Ineffective for the promotion of an antismoking behaviour. Results showed how variables as gender and smoking habits can influence the perception of PSA images, and how different communication styles of the antismoking campaigns could facilitate the comprehension of PSA’s message and then enhance the related impac

Localization of endogenous STX11 & Munc18-2 in CTL

Cytotoxic T-lymphocytes (CTL) kill their targets by cytolytic granule secretion at the immunological synapse. The Sec/Munc protein, Munc18-2, and its binding partner Syntaxin 11 (STX11) are both required for granule secretion, with mutations in either leading to the primary immunodeficiency, Familial Haemophagocytic Lymphohistiocytosis (FHL4 and 5). Understanding how Munc18-2 and STX11 function in CTL has been hampered by not knowing the endogenous localization of these proteins. Using a novel FHL5 Munc18-2 mutation that results in loss of protein, cytotoxicity and degranulation together with CTL from an FHL4 patient lacking STX11, enabled us to localize endogenous STX11 and Munc18-2 in CTL. Munc18-2 localized predominantly to cytolytic granules with low levels associated with the plasma membrane where STX11 localized. Importantly, while Munc18-2 localization is unaffected by the absence of STX11 in FHL4 CTL, STX11 is lost from the plasma membrane in FHL5 CTL lacking Munc18-2. These findings support a role for Munc18-2 in chaperoning STX11 to the plasma membrane where the final fusion events involved in secretion occur.his work was funded by grants from the Wellcome Trust [075880], [100140] and [097024/B/11/Z] (G.M.G); a Daimler Benz scholarship (Y.H.); the Kendal-Dixon Fund (Y.H.); the Cambridge European Trust (Y.H.); King’s College (Cambridge) (Y.H.); the National Institute for Health Research Biomedical Research Center (G.M.G); Antonio Pinzino – Associazione per la Ricerca sulle Sindromi Emofagocitiche (M.A.); Associazione Italiana Ricerca istiocitosi (M.A.); and Italian Ministry of Health, Progetti dioe ricerca finalizzata 2008, Bando Malattie Rare RF-TOS-2008-1219488 (M.A.).This is the final version of the article. It first appeared from Wiley via http://dx.doi.org/10.1111/tra.1233

Hydropower Potential inWater Distribution Networks: Pressure Control by PATs

Pressure control is one of the main techniques to control leakages in Water Distribution Networks (WDNs) and to prevent pipe damage, improving the delivery standards of a water supply systems. Pressure reducing stations (PRSs) equipped by either pressure reducing valves or motor driven regulating valves are commonly used to dissipate excess hydraulic head in WDNs. An integrated new technical solution with economic and system flexibility benefits is presented which replaces PRSs with pumps used as turbines (PATs). Optimal PAT performance is obtained by a Variable Operating Strategy (VOS), recently developed for the design of small hydropower plants on the basis of valve time operation, and net return determined by both energy production and savings through minimizing leakage. The literature values of both leakages costs and energy tariffs are used to develop a buisness plan model and evaluate the economic benefit of small hydropower plants equipped with PATs. The study shows that the hydropower installation produces interesting economic benefits, even in presence of small available power, that could encourage the leakage reduction even if water savings are not economically relevant, with consequent environmental benefits

Catechol-based macrocyclic aromatic ether-sulfones: Synthesis, characterization and ring-opening polymerization

Cyclocondensation between 4,4`-bis(4-chlorobenzenesulfonyl)biphenyl and catechol, with subsequent chromatographic separation of the reaction products, led to the isolation of four novel ether-sulfone macrocycles (cyclic dimer, -trimer, -tetramer and -pentamer). Similarly, cyclocondensation of catechol with a novel seven-ring diketone/disulfone monomer allowed the isolation of the two new aromatic ether-ketone-sulfone macrocycles, a cyclic monomer and a cyclic dimer. Transannular shielding and deshielding effects in the cyclic monomer produce substantial chemical shift differences for chemically equivalent protons in the 1H NMR spectra of the cyclic monomer and -dimer. Fluoride-initiated ring-opening polymerization of the ether-sulfone cyclic trimer affords a novel, high-molecular weight poly(ether-sulfone)

Neurophysiological vigilance characterisation and assessment: Laboratory and realistic validations involving professional air traffic controllers

Vigilance degradation usually causes significant performance decrement. It is also considered the major factor causing the out-of-the-loop phenomenon (OOTL) occurrence. OOTL is strongly related to a high level of automation in operative contexts such as the Air Traffic Management (ATM), and it could lead to a negative impact on the Air Traffic Controllers’ (ATCOs) engagement. As a consequence, being able to monitor the ATCOs’ vigilance would be very important to prevent risky situations. In this context, the present study aimed to characterise and assess the vigilance level by using electroencephalographic (EEG) measures. The first study, involving 13 participants in laboratory settings allowed to find out the neurophysiological features mostly related to vigilance decrements. Those results were also confirmed under realistic ATM settings recruiting 10 professional ATCOs. The results demonstrated that (i) there was a significant performance decrement related to vigilance reduction; (ii) there were no substantial differences between the identified neurophysiological features in controlled and ecological settings, and the EEG-channel configuration defined in laboratory was able to discriminate and classify vigilance changes in ATCOs’ vigilance with high accuracy (up to 84%); (iii) the derived two EEG-channel configuration was able to assess vigilance variations reporting only slight accuracy reduction