Baseline characteristics upon presentation at the Emergency Department (n = 395).

<p>COPD, chronic pulmonary obstructive disease; Chronic Obstructive Pulmonary Disease (COPD) was classified using the global initiative for chronic obstructive lung disease classification (GOLD), Hepatic means liver disease related to malignancy, hepatitis, auto-immune liver disease and/or alcoholic liver disease, cardiac means heart disease related to acute coronary syndrome (cardiovascular disease), valvular disease and/or heart failure, renal means renal disease including current renal replacement therapy, cerebrovascular means cerebrovascular disease; n, number; ICU, intensive care unit; data are presented as number (percentage) of patients.</p

Frequencies of neutrophil-lymphocyte count ratios <10 and ≥10 in subpopulations of patients admitted to the emergency department with community-acquired pneumonia.

<p>NLCR, neutrophil-lymphocyte count ratio; COPD, chronic pulmonary obstructive disease; ICU, intensive care unit; n, number; data are presented as number (percentage) of patients.</p

Admission levels of the neutrophil-lymphocyte count ratio, white blood cell count (×10e9/l) and C-reactive protein level (mg/l) in community-acquired pneumonia patients classified into five CURB-65 categories (0, 1, 2, 3 and 4+5), (NLCR, neutrophil-lymphocyte count ratio; WBC, white blood cell; Y-axis left CRP, C-reactive protein; Y-axis right) data are presented as mean and SD.

<p>Admission levels of the neutrophil-lymphocyte count ratio, white blood cell count (×10e9/l) and C-reactive protein level (mg/l) in community-acquired pneumonia patients classified into five CURB-65 categories (0, 1, 2, 3 and 4+5), (NLCR, neutrophil-lymphocyte count ratio; WBC, white blood cell; Y-axis left CRP, C-reactive protein; Y-axis right) data are presented as mean and SD.</p

Infection markers in patients admitted to the Emergency Department with community-acquired pneumonia and subpopulations of patients admitted to the hospital and patients deceased during hospitalization.

<p>WBC, white blood cell; CRP, C-reactive protein; ICU, intensive care unit; NLCR, neutrophil-lymphocyte count ratio; data are presented as mean (SD).</p

Characteristics of the study population (n = 2,426) and risk factors for pneumonia (186 pneumonia cases and 2,240 non-cases) based on univariate logistic regression analyses.

<p>Significant associations are depicted in bold face.</p

Exposure status and associations from univariate (crude OR) and multiple logistic regression analyses (adjusted OR) between pneumonia and livestock exposure variables.

<p>The proportions of cases attributable to respective exposure is indicated by the population attributable fraction (PAF).</p

Characteristics of the study population for Q fever related exposures.

<p>Characteristics of the study population for Q fever related exposures.</p

Comparison of hospitalized acute Q fever pneumonia patients (n = 154) with patients admitted with a community-acquired pneumonia (CAP) (n = 254) and with CAP patients with bacterial aetiology other than <i>C. burnetii</i> (n = 104).

<p>IQR: interquartile range; COPD: chronic obstructive pulmonary disease.</p>a<p>Chi-square test.</p>b<p>Mann-Whitney U test.</p>c<p>Information missing or unknown for seven Q fever pneumonia patients, 56 CAP patients and 24 bacterial pneumonia patients.</p>d<p>Three CAP patients who died on the same day as visiting the emergency department not included, two patients not included in the bacterial pneumonia group.</p>e<p>Information missing for three Q fever pneumonia patients, 46 CAP patients and 19 bacterial pneumonia patients.</p>f<p>Information missing or unknown for 36 CAP patients and 18 bacterial pneumonia patients.</p>g<p>Information missing or unknown for 31 CAP patients and 13 bacterial pneumonia patients.</p>h<p>Pneumonia Severity Index (PSI): risk class: I–III = low; IV = moderate; V = severe.</p>i<p>Information missing for 29 CAP patients and 13 bacterial pneumonia patients.</p>j<p>Chi-square test for trend.</p>k<p>Confusion, blood Urea nitrogen, Respiratory rate, Blood pressure, age≥65 (CURB-65) score: 0–1 = mild pneumonia; 2 = moderate pneumonia; 3–5 = severe pneumonia.</p>l<p>Information missing for 27 CAP patients and 12 bacterial pneumonia patients.</p>m<p>Severe pneumonia is defined as PSI risk class ≥IV and/or CURB-score ≥2.</p

Symptoms at time of admission of hospitalized acute Q fever patients (n = 183).

<p>Symptoms at time of admission of hospitalized acute Q fever patients (n = 183).</p

Baseline characteristics of hospitalized acute Q fever patients from 2007 to 2009 (n = 183) compared with the general Dutch population in the region and nationwide.

<p>COPD: chronic obstructive pulmonary disease; CVA: cerebrovascular accident; IQR: interquartile range; MHS: Municipal Health Service.</p>a<p>Unless otherwise indicated, data extracted from Statistics Netherlands (CBS), 2008–2011: <a href="http://statline.cbs.nl/statweb/(website" target="_blank">http://statline.cbs.nl/statweb/(website</a> accessed 2013 July 30) <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0091764#pone.0091764-Statistics1" target="_blank">[27]</a>.</p>b<p>Information missing for nine cases.</p>c<p>Information missing for 18 cases.</p>d<p>Information missing for three cases.</p>e<p>Prevalence in 2007, data extracted from National Public Health Compass: <a href="http://www.nationaalkompas.nl/gezondheid-en-ziekte/ziekten-en-aandoeningen/hartvaatstelsel/hartfalen/cijfers-hartfalen-prevalentie-incidentie-en-sterfte-uit-de-vtv-2010/(website" target="_blank">http://www.nationaalkompas.nl/gezondheid-en-ziekte/ziekten-en-aandoeningen/hartvaatstelsel/hartfalen/cijfers-hartfalen-prevalentie-incidentie-en-sterfte-uit-de-vtv-2010/(website</a> accessed 2013 July 30) <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0091764#pone.0091764-Gommer1" target="_blank">[26]</a>.</p>f<p>20-years prevalence in 2009, data extracted from Comprehensive Cancer Centre the Netherlands (IKNL): <a href="http://www.cijfersoverkanker.nl/(website" target="_blank">http://www.cijfersoverkanker.nl/(website</a> accessed 2013 July 30) <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0091764#pone.0091764-Comprehensive1" target="_blank">[25]</a>.</p