Interferon-?2b may impair myelinization of rat optic nerve

PubMedID: 16644604This story investigated the effects of interferon-alpha-2b (IFN-?2b) on the optic nerves of 17 adult male Wistar albino rats. Animals were divided into 3 groups: 6 rats (group 1) received 7.5 units (5 mIU/m 2 ) IFN-?2b-a normal treatment dose, and 6 (groups 2) received 30.0 units (20 mIU/m 2 )-a high dose; 5 rats (control group) received 0.5 mL saline. Test substances were delivered by intraperitoneal injection 3 times a week for 3 weeks with animals under inhalation anesthesia. After the rats were sacrificed, their optic nerves were dissected, sectioned, and examined under an electron microscope. The mean thicknesses of the basal membranes of blood vessels were 86.354 nm in the control group, 104.297 nm in group 1, and 140.181 nm in group 2. Basal membrane changes in IFN groups were dose dependent. Mitochondrial swelling, degeneration, increased diameter of vacuoles, and vacuolization in the cytoplasm of oligodendrocytes and astrocytes were also observed. IFN-?2b has histopathologic effects on blood vessels and cells of the optic nerve. ©2006 Health Communications Inc

Very low dose methotrexate-induced rheumatoid nodules localized in buttocks and palmar aspects of phalanges: Case report [Kalça ve parmaklann palmar yüzlerinde lokalize ve çok düşük doz metotreksat ile ortaya çi{dotless}kan romatoid noduller]

Rheumatoid nodules are the most common extra-articular lesions. They usually occur in rheumatoid factor positive patients and indicate activity and severity of the disease. These nodules characteristically occur subcutaneously on extensor surfaces over the elbows or other bony prominences. They may be overlooked if they occur in sites other than well-known areas. We present a case with rheumatoid arthritis (RA) who developed multiple subcutaneous, histologically- proven rheumatoid nodules in both buttocks as well as on palmar aspects of phalanges after 3.5 years of very low-dose weekly methotrexate (MTX) treatment. These nodules occurred abruptly while there was not active arthritis in any joint. MTX-induced large nodules may occur even with very low doses of MTX, in atypical localizations such as both buttocks. © 2011 by Türkiye Klinikleri

Chondroblastoma: review of fifty-five cases

WOS: 00034438680214

Amyloid deposition in knee and ankle joints in the course of multiple myeloma{lozenge, open}{lozenge, open}Pour citer cet article, utiliser ce titre en anglais et sa référence dans le même volume de Joint Bone Spine. [Dépots amyloïdes dans les articulations du genou et de la cheville au cours d'un myelome multiple]

[No abstract available

Cystic bone lesions: Histopathological spectrum and diagnostic challenges [Kemiğin Kistik Lezyonları: Histopatolojik Spektrum ve Tanısal Güçlükler]

PubMed ID: 25652560Objective: Bone cysts are benign lesions occurring in any bone, regardless of age. They are often asymptomatic but may cause pain, swelling, fractures, and local recurrence and may be confused with other bone lesions. Material and Method: We retrospectively re-evaluated 143 patients diagnosed with aneurysmal bone cyst (n=98, 68.5%), solitary bone cysts (n=17 11.9%), pseudocyst (n=10.7%), intraosseous ganglion (n=3, 2.1%), hydatid cyst (n=2; 1.4), epidermoid cyst (n=1, 0.7%) and cysts demonstrating “mixed” aneurysmal-solitary bone cyst histology (n=12, 8.4%), and compared them with nonparametric tests. Results: Aneurysmal bone cyst, solitary bone cysts and mixed cysts were frequently seen in the first two decades of life while the others occurred after the fourth decade. Aneurysmal bone cysts, intraosseous ganglion and pseudocysts were more common in women contrary to solitary bone cyst and mixed cysts (the female/male ratio was 1.22, 2 and 1.5 versus 0.7 and 0.5, respectively). Aneurysmal bone cyst, solitary bone cysts and “mixed” cysts were mostly seen in long bones, predominantly the femur, while epidermoid, hydatid and pseudocysts were all seen in fat bones like the vertebra, pelvis and mandible (p=0.001, chi-square). repeat biopsies were performed in 19 cases (13.3%), 84.2% of which were aneurysmal bone cyst (5 conventional, 9 solid, 1 secondary and 1 subperiosteal) and three (15.8%) were mixed cysts (p=0.02, chi-square). Notably, some of them were located in inaccessible areas of pelvis (n=3), femur (n=3) and maxilla (n=2). Conclusion: The most common and challenging intraosseous cysts are aneurysmal bone cysts, particularly the “solid” variant. The “mixed” aneurysmal-solitary bone cyst “subgroup” requires further research with larger series to be defined more thoroughly. © 2015, Federation of Turkish Pathology Societies. All Rights Reserved