Plastically-driven variation of elastic stiffness in green bodies during powder compaction. Part II: Micromechanical modelling

A micromechanical approach is set-up to analyse the increase in elastic stiffness related to development of plastic deformation (the elastoplastic coupling concept) occurring during the compaction of a ceramic powder. Numerical simulations on cubic (square for 2D) and hexagonal packings of elastoplastic cylinders and spheres validate both the variation of the elastic modulus with the forming pressure and the linear dependence of it on the relative density as experimentally found in Part~I of this study, while the dependence of the Poisson's ratio on the green's density is only qualitatively explained

Kidney: t(X;17)(p11.2;q23) in renal cell carcinoma

Review on Kidney: t(X;17)(p11.2;q23) in renal cell carcinoma, with data on clinics, and the genes involved

Kidney: t(6;11)(p21;q12) in renal cell carcinoma

Review on Kidney: t(6;11)(p21;q12) in renal cell carcinoma, with data on clinics, and the genes involved

CLTC (clathrin heavy polypeptide)

Review on CLTC (clathrin heavy polypeptide), with data on DNA, on the protein encoded, and where the gene is implicated

Kidney: inv(X)(p11.2;q12) in renal cell carcinoma

Review on Kidney: inv(X)(p11.2;q12) in renal cell carcinoma, with data on clinics, and the genes involved

Quasi-periodicity and multi-scale resonators for the reduction of seismic vibrations in fluid-solid systems

This paper presents a mathematical model for an industry-inspired problem of vibration isolation applied to elastic fluid-filled containers. A fundamental problem of suppression of vibrations within a finite-width frequency interval for a multi-scale fluid-solid system has been solved. We have developed a systematic approach employing full fluid-solid interaction and dispersion analysis, which can be applied to finite and periodic multi-scale systems. The analytical findings are accompanied by numerical simulations, including frequency response analyses and transient regime computations

Anatomical differences in the right and left renal arterial patterns

The aim of this study was to determine the pattern and character of the renal arteries in patients referred for preoperative or diagnostic evaluation of the renal or abdominal arteries by multi-detector computed tomography and, by comparing the arterial anatomy of the right and left kidneys, to evaluate the effect of differences in their anatomical position on the characteristics of the arteries. During a cross-sectional study from August 2005 to October 2007, 117 patients underwent contrast-enhanced 64-slice multi-detector computed tomography renal angiography in Tabriz Imam Khomeini Hospital (Parsian Centre). The number of arteries, the number of branches and the presence of accessory arteries and early branching were assessed in the renal arteries on both sides. In all, the data for 117 patients data were analysed, 76 (65%) of whom were male and 41 (35%) female. The mean of age of the patients was 39.26 ± ± 17.03 years. The mean diameters of the aorta and renal artery were 2.62 ± ± 1.55 mm and 0.62 ± 0.11 mm respectively and the distance to branching was 3.39 ± 1.59 mm. There was no significant difference in diameter between the left and right renal arteries or in the distance to branching (0.62 ± 0.11 vs. 0.61 ± 0.12 mm; p = 0.35; 3.24 ± 1.2 vs. 3.56 ± 1.77 mm; p = 0.11). An accessory artery was presented in 58 kidneys and this significantly more often occurred on the right side than on the left side: 38 of 117 (32.47%) right kidneys vs. 20 of 117 (17.09%) left kidneys (p = 0.01). There was early branching in 42 subjects (35.89%). In a comparison of early branching of the arteries of the right and left kidneys, no significant difference was found, despite the higher incidence of branching on the right side. The diameters of the right and left renal arteries and the distances to branching did not differ. Apart from width, there was no difference in kidney size. An accessory artery occurred more frequently in the right renal artery than in the left. (Folia Morphol 2008; 67: 104-110

A primary breast cancer with distinct foci of estrogen receptor-alpha positive and negative cells derived from the same clonal origin as revealed by whole exome sequencing

© 2018, Springer Science+Business Media, LLC, part of Springer Nature. Background/purpose: Tumor heterogeneity is a now well-recognized phenomenon that can affect the classification, prognosis and treatment of human cancers. Heterogeneity is often described in primary breast cancers based upon histologic subtypes, hormone- and HER2-receptor status, and immunolabeling for various markers, which can be seen within a single tumor as mixed cellular populations, or as separate discrete foci. Experimental design/methods: Here, we present a case report of a patient’s primary breast cancer that had two separate but adjacent histologic components, one that was estrogen receptor (ER) positive, and the other ER negative. Each component was subjected to whole exome sequencing and compared for gene identity to determine clonal origin. Results: Using prior bioinformatic tools, we demonstrated that both the ER positive and negative components shared many variants, including passenger and driver alterations. Copy number variations also supported the two components were derived from a single common clone. Conclusions: These analyses strongly suggest that the two ER components of this patient’s breast cancer were derived from the same clonal origin. Our results have implications for the evolution of breast cancers with mixed histologies, and how they might be best managed for optimal therapy