Highly efficient chemo- and enantioselective enzymatic resolution of (±)-methyl O-acetylmandelates

918-92

Amano PS catalysed methanolysis of maleimides: An efficient synthesis of methyl maleanilates^†

1899-1901A first simple method for Amano PS catalysed methanolysis of maleimides 1a-f has been described to obtain methyl maleanilates 2a-f in 80-90% yields

Synthesis of chenopanone

1140-1142Starting from glyoxalic acid, a facile three step approach to chenopanone has been described utilizing the Barbier reaction as a key step

General approach to 2,4-dialkyl-3-carboxybutyrolactones: An efficient synthesis of (±)-striatisporolide A and (±)-lichesterinic acid

1071-1075Starting from 2-alkylidene-3-methylsuccinimides, simple and efficient synthesis of the natural products striatisporolide A, lichesterinic acid and lichesterylic acid have been demonstrated via an acid catalyzed hydrolysis, esterification, OsO4-dihydroxylation and dehydrative cyclization pathway

Rearrangement of imine double bond in activated quinazolinones: Synthesis of phaitanthrin E

527-530Wolff-Kishner reduction of tryptanthrin to indoloquinazolinone followed by lithium diisorpropylamide induced acylation of the active methylene group with methyl chloroformate directly furnishes the phaitanthrin E in very good yield. Similar acylations of indoloquinazolinone have also been performed with four different acyl chlorides. In all examples, facile rearrangement of imine double bond from quinazolinone to indole moiety to form the corresponding α,β-unsaturated carbonyl system is observed

Stereoselective synthesis of subincanadine alkaloids framework

669-673Starting from N-tosyltryptamine and (S)-acetoxysuccinic anhydride, a facile synthesis of (‒)-indolizinoindolone has been demonstrated as a basic structural outline of bioactive subincanadine alkaloids. Regioselective Grignard reaction with (S)-acetoxysuccinimide, stereoselective intramolecular cyclization to form (‒)-indolizinoindolone skeleton and TiCl4 induced condensation with acetaldehyde for stereoselective generation of exocyclic carbon‒carbon double bond are the key features