Arganiella wolfi, new combination for Boetersiella wolfi (Boeters & Gloer, 2007)

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Descripción de una nueva especie del género Arganiella Giusti y Pezzoli, 1980 (Mollusca, Gastropoda, Hydrobiidae) en la Península Ibérica

A new species of Arganiella Giusti & Pezzoli, 1980, up to now a monotypic genus, thought to be endemic to the Italian Central Apennines, is described from the Iberian Peninsula. This new species, named Arganiella tartessica, is located in southwestern Spain, provinces of Huelva and Badajoz. In this paper, a detailed description of its morphological characters is given and new data of nervous system and ciliated areas in the cephalic region are provided.Se describe una especie ibérica de Arganiella Giusti y Pezzoli, 1980, un género que hasta ahora se consideraba monotípico y endémico de los Apeninos centrales italianos. Esta nueva especie, denominada Arganiella tartessica, ha sido localizada en el sureste español, en las provincias de Huelva y Badajoz. En este artículo se describen en detalle sus caracteres morfológicos y se presentan datos, hasta la fecha desconocidos en el género Arganiella, del sistema nervioso y de áreas ciliadas en la región cefálica

Estudio de los impactos ambientales de los cruces de gasoductos con ríos vadeables

El río Cigüela y su afluente Valdepineda (Cuenca, España) fueron afectados por el cruce de un gasoducto, en Diciembre de 2001, mediante la técnica convencional "cruce subálveo" que consta de tres fases: instalación de la pista de trabajo, apertura de zanja y rehabilitación. Con el objetivo de evaluar el impacto de las distintas etapas de la obra en el medio acuático, se está llevando a cabo un estudio que se centra en el efecto de los sólidos en suspensión en las comunidades macrobentónicas e ícticas. Se presentan los resultados preliminares obtenidos en la fase de apertura de zanja, donde se observa un valor muy elevado de movilización de sólidos en suspensión (hasta 5000 mg/l), alcanzando las mayores concentraciones en los 100 primeros metros aguas abajo del punto de cruce. Estos sólidos en suspensión podrían ser la causa del aumento significativo de la sedimentación de las partículas de tamaño comprendido entre 50-250 μm y 250-500 μm en los 30 primeros metros aguas abajo del punto de cruce. Por otro lado, no se han observado diferencias en el valor del índice BMWP' en las distintas estaciones de muestreo. Sin embargo, en la fase de rehabilitación, se encuentra una diferencia significativa en la frecuencia de distribución de algunas de las especies de peces presentes en el río, además se observa un claro efecto barrera para la ictiofauna al eliminar la pista de trabajo.The Cigüela River and its tributary, Valdepineda (Cuenca, España) were affected by the crossing of a natural gas pipeline, in December 2001, by means of the conventional technique "open-cut water crossing" that consists of three different works: installation of the right-of-way, excavation and backfill of the pipeline trench, and restoration. In order to assess the impacts of these different activities on the aquatic environment, we are carrying out a study that is focused on the effects of suspended solids in the benthic and fish communities. Preliminary results of this study are presented on the excavation and backfill of the pipeline trench, that indicate that a very high value of suspended solids mobilisation is observed (up to 5000 mg/l), reaching the higher concentrations in the first 100 meters downstream of the crossing site. These suspended solids might be responsible for the significant increase in the sedimentation of the particles of sizes 50-250 μm and 250-500 μm in the 30 first meters downstream of the crossing site. On the other hand, we have not found differences in the values of the BMWP' index at the different sampling sites. Nevertheless, in the restoration phase , there is a significant difference in the distribution frequency of some fish species that appear in the river and also a clear barrier effect is observed for fishes when eliminating the right-of-way

Gastrodin Inhibits Allodynia and Hyperalgesia in Painful Diabetic Neuropathy Rats by Decreasing Excitability of Nociceptive Primary Sensory Neurons

Painful diabetic neuropathy (PDN) is a common complication of diabetes mellitus and adversely affects the patients’ quality of life. Evidence has accumulated that PDN is associated with hyperexcitability of peripheral nociceptive primary sensory neurons. However, the precise cellular mechanism underlying PDN remains elusive. This may result in the lacking of effective therapies for the treatment of PDN. The phenolic glucoside, gastrodin, which is a main constituent of the Chinese herbal medicine Gastrodia elata Blume, has been widely used as an anticonvulsant, sedative, and analgesic since ancient times. However, the cellular mechanisms underlying its analgesic actions are not well understood. By utilizing a combination of behavioral surveys and electrophysiological recordings, the present study investigated the role of gastrodin in an experimental rat model of STZ-induced PDN and to further explore the underlying cellular mechanisms. Intraperitoneal administration of gastrodin effectively attenuated both the mechanical allodynia and thermal hyperalgesia induced by STZ injection. Whole-cell patch clamp recordings were obtained from nociceptive, capsaicin-sensitive small diameter neurons of the intact dorsal root ganglion (DRG). Recordings from diabetic rats revealed that the abnormal hyperexcitability of neurons was greatly abolished by application of GAS. To determine which currents were involved in the antinociceptive action of gastrodin, we examined the effects of gastrodin on transient sodium currents (INaT) and potassium currents in diabetic small DRG neurons. Diabetes caused a prominent enhancement of INaT and a decrease of potassium currents, especially slowly inactivating potassium currents (IAS); these effects were completely reversed by GAS in a dose-dependent manner. Furthermore, changes in activation and inactivation kinetics of INaT and total potassium current as well as IAS currents induced by STZ were normalized by GAS. This study provides a clear cellular basis for the peripheral analgesic action of gastrodin for the treatment of chronic pain, including PDN

P2Y receptors and pain transmission

It is widely accepted that the most important ATP receptors involved in pain transmission belong to the P2X3 and P2X2/3 subtypes, selectively expressed in small diameter dorsal root ganglion (DRG) neurons. However, several types of the metabotropic ATP (P2Y) receptors have also been found in primary afferent neurons; P2Y1 and P2Y2 receptors are typically expressed in small, nociceptive cells. Here we review the results available on the involvement of P2Y receptors in the modulation of pain transmission

Seguimiento de las guías españolas para el manejo del asma por el médico de atención primaria: un estudio observacional ambispectivo

Objetivo Evaluar el grado de seguimiento de las recomendaciones de las versiones de la Guía española para el manejo del asma (GEMA 2009 y 2015) y su repercusión en el control de la enfermedad. Material y métodos Estudio observacional y ambispectivo realizado entre septiembre del 2015 y abril del 2016, en el que participaron 314 médicos de atención primaria y 2.864 pacientes. Resultados Utilizando datos retrospectivos, 81 de los 314 médicos (25, 8% [IC del 95%, 21, 3 a 30, 9]) comunicaron seguir las recomendaciones de la GEMA 2009. Al inicio del estudio, 88 de los 314 médicos (28, 0% [IC del 95%, 23, 4 a 33, 2]) seguían las recomendaciones de la GEMA 2015. El tener un asma mal controlada (OR 0, 19, IC del 95%, 0, 13 a 0, 28) y presentar un asma persistente grave al inicio del estudio (OR 0, 20, IC del 95%, 0, 12 a 0, 34) se asociaron negativamente con tener un asma bien controlada al final del seguimiento. Por el contrario, el seguimiento de las recomendaciones de la GEMA 2015 se asoció de manera positiva con una mayor posibilidad de que el paciente tuviera un asma bien controlada al final del periodo de seguimiento (OR 1, 70, IC del 95%, 1, 40 a 2, 06). Conclusiones El escaso seguimiento de las guías clínicas para el manejo del asma constituye un problema común entre los médicos de atención primaria. Un seguimiento de estas guías se asocia con un control mejor del asma. Existe la necesidad de actuaciones que puedan mejorar el seguimiento por parte de los médicos de atención primaria de las guías para el manejo del asma. Objective: To assess the degree of compliance with the recommendations of the 2009 and 2015 versions of the Spanish guidelines for managing asthma (Guía Española para el Manejo del Asma [GEMA]) and the effect of this compliance on controlling the disease. Material and methods: We conducted an observational ambispective study between September 2015 and April 2016 in which 314 primary care physicians and 2864 patients participated. Results: Using retrospective data, we found that 81 of the 314 physicians (25.8%; 95% CI 21.3–30.9) stated that they complied with the GEMA2009 recommendations. At the start of the study, 88 of the 314 physicians (28.0%; 95% CI 23.4–33.2) complied with the GEMA2015 recommendations. Poorly controlled asthma (OR, 0.19; 95% CI 0.13–0.28) and persistent severe asthma at the start of the study (OR, 0.20; 95% CI 0.12–0.34) were negatively associated with having well-controlled asthma by the end of the follow-up. In contrast, compliance with the GEMA2015 recommendations was positively associated with a greater likelihood that the patient would have well-controlled asthma by the end of the follow-up (OR, 1.70; 95% CI 1.40–2.06). Conclusions: Low compliance with the clinical guidelines for managing asthma is a common problem among primary care physicians. Compliance with these guidelines is associated with better asthma control. Actions need to be taken to improve primary care physician compliance with the asthma management guidelines

A new genus and a new species of hydrobiid snail (Mollusca: Gastropoda: Hydrobiidae) from eastern Spain

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