NIOSOMES: A PROMISING VESICULAR DRUG DELIVERY SYSTEM FOR TUBERCULOSIS

The drug ethambutol HCl is one of the first line antitubercular agent available in tablet form used in the treatment of pulmonary tuberculosis disease, for long term therapy but according to researcher the drug shows poor absorptivity in presence of food when administered orally & required higher dose of about 25mg/kg, also has short half life i.e.2-4 hrs., so to well utilization of drug as well as to minimize the side effects, there should have to modify the formulation in other suitable dosage form, like vesicular drug delivery system, in which incorporating the drug into system in the form of niosomes, and its characteristic action gives the sustained release of dose. So the present work of this research was to prepared and evaluate the niosomal drug delivery system by reverse phase evaporation method and were evaluated their particle size analysis, surface morphology, entrapment efficiency, in-vitro release profile etc. Key word: Ethambutol HCl, Niosomes, Tuberculosis, Vesicular drug delivery system, in-vitro release etc