1,3:4,6-Di-O-benzylidene-d-mannitol as a source for novel chiral intermediates through regioselective reductive cleavage

Synthetically useful chiral intermediates have been synthesized starting from 1,3:4,6-di-O-benzylidene-d-mannitol by regioselective reductive cleavage using BF3·Et2O and Et3SiH in high yields

A highly regio- and chemoselective reductive cleavage of benzylidene acetals with EtAlCl₂-Et₃SiH

A highly regio- and chemoselective reductive cleavage of benzylidene acetals derived from 1,2- and 1,3-diols was achieved under mild conditions using EtAlCl2-Et3SiH reagent system in good to excellent yields. Labile protecting groups such as N-Boc, N-Cbz and -OTBDMS are found to be stable under the reaction conditions

Regioselective oxidative cleavage of benzylidene acetals: synthesis of highly functionalized chiral intermediates

A mild and efficient method for the regioselective oxidative cleavage of benzylidene acetals with KBrO₃/Na₂S₂O₄ under bi-phasic conditions (EtOAc/H2O), leading to highly functionalized chiral intermediates, is reported

Diversity-oriented synthesis of useful chiral building blocks from D-mannitol

A diversity-oriented synthesis is described for functionalized chiral building blocks (i.e., 7, 9, 10, 16, and 17) and the biologically active iminosugar, fucosidase inhibitor (2S,3R,4R,5R)-2-(hydroxymethyl)-5-methylpyrrolidine-3,4-diol (22), starting from common chiral intermediate 1a which is obtained through a regioselective reductive cleavage of a bis(benzylidene) acetal

Regioselective cleavage of the bis-benzylidene acetal of d-mannitol under oxidative and reductive conditions: a new approach to C₂-symmetric chiral ligands

A highly regioselective oxidative cleavage of 1,3:4,6-di-O-benzylidene-d-mannitol was carried out using NBS and the resultant product was readily converted to the C2-symmetric chiral ligand, (R,R)-3,4-dihydroxy-1,5-hexadiene. On the other hand, reductive cleavage of 1,3:4,6-di-O-benzylidene-d-mannitol was achieved in a highly regioselective manner using BF3·OEt2 and Et3SiH to give a highly functionalized benzyl ether, which was converted to a synthetically useful C2-symmetric bis-amino alcohol derivative

Review of strategies toward the development of alloy two-dimensional (2D) transition metal dichalcogenides

Atomically thin two-dimensional (2D) transition metal dichalcogenides (TMDCs) have attracted significant attention owing to their prosperity in material research. The inimitable features of TMDCs triggered the emerging applications in diverse areas. In this review, we focus on the tailored and engineering of the crystal lattice of TMDCs that finally enhance the efficiency of the material properties. We highlight several preparation techniques and recent advancements in compositional engineering of TMDCs structure. We summarize different approaches for TMDCs such as doping and alloying with different materials, alloying with other 2D metals, and scrutinize the technological potential of these methods. Beyond that, we also highlight the recent significant advancement in preparing 2D quasicrystals and alloying the 2D TMDCs with MAX phases. Finally, we highlight the future perspectives for crystal engineering in TMDC materials for structure stability, machine learning concept marge with materials, and their emerging applications.The authors acknowledge that the study was supported as part of the Computational Materials Sciences Program funded by the U.S. Department of Energy, Office of Science, Basic Energy Sciences , under Award Number DE-SC0014607 . P.K., C.S.T. and V.K. acknowledge AOARD ( Asian Office of Aerospace Research and Development ) grant no. FA2386-19-1-4039 and Grant No. FA2386-21-1-4014 . C.S.T. acknowledges Ramanujan fellowship and core research grant of SERB, India. CST acknowledges the funding received from STARS project by MHRD, India.Scopu