Cerebral and cardiovascular effects of analgesic doses of ketamine during a target controlled general anesthesia: a prospective randomized study

Introduction: Ketamine is increasingly being used in various pain settings. The purpose of this study was to assess the effect of an analgesic dose of ketamine in the bispectral index (BIS), spectral edge frequency (SEF-95), density spectral array (DSA), cerebral oximetry (rSO2) and mean arterial pressure (MAP) during general anaesthesia with a target controlled infusion. Methods: A prospective, single-blinded and randomized study on adult patients scheduled for elective spine surgery was carried out. After anaesthesia induction with propofol, remifentanil and rocuronium, when a stable BIS value (45-55) was achieved, an automatic recording of BIS, SEF-95, rSO2 and MAP values during 9 min was performed to establish patients baseline values. Subsequently, patients were randomly assigned to receive a ketamine bolus dose of 0.2 mg/kg, 0.5 mg/kg or 1 mg/kg; all variables were recorded for additional 9 min after the ketamine bolus, in the absence of any surgical stimulus. A p-value <0.05 was considered significant in the statistical analysis. Results and discussion: Thirty-nine patients were enrolled in the study. Our results show a dose-related increase of SEF-95 and BIS values. DSA demonstrate a shift in the frequency range and power distribution towards higher frequencies. Our results do not show significant differences in MAP and rSO2 values. Conclusion: When ketamine is used intraoperatively in analgesic doses, the anaesthetist should anticipate an increase in SEF-95 and BIS values which will not be associated with the level of anaesthesia.info:eu-repo/semantics/publishedVersio

Dynamical demixing of a binary mixture under sedimentation

We investigate the sedimentation dynamics of a binary mixture, the species of which differ by their Stokes coefficients but are identical otherwise. We analyze the sedimentation dynamics and the morphology of the final deposits using Brownian dynamics simulations for mixtures with a range of sedimentation velocities of both species. We found a threshold in the sedimentation velocities difference above which the species in the final deposit are segregated. The degree of segregation increases with the difference in the Stokes coefficients or the sedimentation velocities above the threshold. We propose a simple mean-field model that captures the main features of the simulated deposits

Fundraising and vote distribution: a non-equilibrium statistical approach

The number of votes correlates strongly with the money spent in a campaign, but the relation between the two is not straightforward. Among other factors, the output of a ballot depends on the number of candidates, voters, and available resources. Here, we develop a conceptual framework based on Shannon entropy maximization and Superstatistics to establish a relation between the distributions of money spent by candidates and their votes. By establishing such a relation, we provide a tool to predict the outcome of a ballot and to alert for possible misconduct either in the report of fundraising and spending of campaigns or on vote counting. As an example, we consider real data from a proportional election with $6323$ candidates, where a detailed data verification is virtually impossible, and show that the number of potential misconducting candidates to audit can be reduced to only nine

Irreversibility line and low-field grain-boundary pinning in electron-doped superconducting thin films

AC magnetic susceptibilities of electron-doped Pr_{1.85}Ce_{0.15}CuO_4 (PCCO) and Sm_{1.85}Ce_{0.15}CuO_4 (SCCO) granular thin films have been measured as a function of temperature and magnetic-field strength. Depending on the level of homogeneity of our films, two different types of the irreversibility line (IL) defined as the intergrain-loss peak temperature in the imaginary part of susceptibility have been found. The obtained results are described via the critical-state model taking into account the low-field grain-boundary pinning. The extracted pinning-force densities in more granular SCCO films turn out to be four times larger than their counterparts in less granular PCCO films

Hubbard-model description of the high-energy spin-spectral-weight distribution in La(2)CuO(4)

The spectral-weight distribution in recent neutron scattering experiments on the parent compound La$_2$CuO$_4$ (LCO), which are limited in energy range to about 450\,meV, is studied in the framework of the Hubbard model on the square lattice with effective nearest-neighbor transfer integral $t$ and on-site repulsion $U$. Our study combines a number of numerical and theoretical approaches, including, in addition to standard treatments, density matrix renormalization group calculations for Hubbard cylinders and a suitable spinon approach for the spin excitations. Our results confirm that the $U/8t$ magnitude suitable to LCO corresponds to intermediate $U$ values smaller than the bandwidth $8t$, which we estimate to be $8t \approx 2.36$ eV for $U/8t\approx 0.76$. This confirms the unsuitability of the conventional linear spin-wave theory. Our theoretical studies provide evidence for the occurrence of ground-state d-wave spinon pairing in the half-filled Hubbard model on the square lattice. This pairing applies only to the rotated-electron spin degrees of freedom, but it could play a role in a possible electron d-wave pairing formation upon hole doping. We find that the higher-energy spin spectral weight extends to about 566 meV and is located at and near the momentum $[\pi,\pi]$. The continuum weight energy-integrated intensity vanishes or is extremely small at momentum $[\pi,0]$. This behavior of this intensity is consistent with that of the spin waves observed in recent high-energy neutron scattering experiments, which are damped at the momentum $[\pi,0]$. We suggest that future LCO neutron scattering experiments scan the energies between 450 meV and 566 meV and momenta around $[\pi,\pi]$.Comment: 23 pages, 5 figure