15,538 research outputs found
Cerebral and cardiovascular effects of analgesic doses of ketamine during a target controlled general anesthesia: a prospective randomized study
Introduction: Ketamine is increasingly being used in various pain settings. The purpose of this study was to
assess the effect of an analgesic dose of ketamine in the bispectral index (BIS), spectral edge frequency (SEF-95), density spectral array (DSA), cerebral oximetry (rSO2) and mean arterial pressure (MAP) during general
anaesthesia with a target controlled infusion.
Methods: A prospective, single-blinded and randomized study on adult patients scheduled for elective spine
surgery was carried out. After anaesthesia induction with propofol, remifentanil and rocuronium, when a stable BIS
value (45-55) was achieved, an automatic recording of BIS, SEF-95, rSO2 and MAP values during 9 min was
performed to establish patients baseline values. Subsequently, patients were randomly assigned to receive a
ketamine bolus dose of 0.2 mg/kg, 0.5 mg/kg or 1 mg/kg; all variables were recorded for additional 9 min after the
ketamine bolus, in the absence of any surgical stimulus. A p-value <0.05 was considered significant in the statistical
analysis.
Results and discussion: Thirty-nine patients were enrolled in the study. Our results show a dose-related
increase of SEF-95 and BIS values. DSA demonstrate a shift in the frequency range and power distribution towards
higher frequencies. Our results do not show significant differences in MAP and rSO2 values.
Conclusion: When ketamine is used intraoperatively in analgesic doses, the anaesthetist should anticipate an
increase in SEF-95 and BIS values which will not be associated with the level of anaesthesia.info:eu-repo/semantics/publishedVersio
Dynamical demixing of a binary mixture under sedimentation
We investigate the sedimentation dynamics of a binary mixture, the species of
which differ by their Stokes coefficients but are identical otherwise. We
analyze the sedimentation dynamics and the morphology of the final deposits
using Brownian dynamics simulations for mixtures with a range of sedimentation
velocities of both species. We found a threshold in the sedimentation
velocities difference above which the species in the final deposit are
segregated. The degree of segregation increases with the difference in the
Stokes coefficients or the sedimentation velocities above the threshold. We
propose a simple mean-field model that captures the main features of the
simulated deposits
Fundraising and vote distribution: a non-equilibrium statistical approach
The number of votes correlates strongly with the money spent in a campaign,
but the relation between the two is not straightforward. Among other factors,
the output of a ballot depends on the number of candidates, voters, and
available resources. Here, we develop a conceptual framework based on Shannon
entropy maximization and Superstatistics to establish a relation between the
distributions of money spent by candidates and their votes. By establishing
such a relation, we provide a tool to predict the outcome of a ballot and to
alert for possible misconduct either in the report of fundraising and spending
of campaigns or on vote counting. As an example, we consider real data from a
proportional election with candidates, where a detailed data
verification is virtually impossible, and show that the number of potential
misconducting candidates to audit can be reduced to only nine
Irreversibility line and low-field grain-boundary pinning in electron-doped superconducting thin films
AC magnetic susceptibilities of electron-doped Pr_{1.85}Ce_{0.15}CuO_4 (PCCO)
and Sm_{1.85}Ce_{0.15}CuO_4 (SCCO) granular thin films have been measured as a
function of temperature and magnetic-field strength. Depending on the level of
homogeneity of our films, two different types of the irreversibility line (IL)
defined as the intergrain-loss peak temperature in the imaginary part of
susceptibility have been found. The obtained results are described via the
critical-state model taking into account the low-field grain-boundary pinning.
The extracted pinning-force densities in more granular SCCO films turn out to
be four times larger than their counterparts in less granular PCCO films
Hubbard-model description of the high-energy spin-spectral-weight distribution in La(2)CuO(4)
The spectral-weight distribution in recent neutron scattering experiments on
the parent compound LaCuO (LCO), which are limited in energy range to
about 450\,meV, is studied in the framework of the Hubbard model on the square
lattice with effective nearest-neighbor transfer integral and on-site
repulsion . Our study combines a number of numerical and theoretical
approaches, including, in addition to standard treatments, density matrix
renormalization group calculations for Hubbard cylinders and a suitable spinon
approach for the spin excitations. Our results confirm that the
magnitude suitable to LCO corresponds to intermediate values smaller than
the bandwidth , which we estimate to be eV for
. This confirms the unsuitability of the conventional linear
spin-wave theory. Our theoretical studies provide evidence for the occurrence
of ground-state d-wave spinon pairing in the half-filled Hubbard model on the
square lattice. This pairing applies only to the rotated-electron spin degrees
of freedom, but it could play a role in a possible electron d-wave pairing
formation upon hole doping. We find that the higher-energy spin spectral weight
extends to about 566 meV and is located at and near the momentum .
The continuum weight energy-integrated intensity vanishes or is extremely small
at momentum . This behavior of this intensity is consistent with that
of the spin waves observed in recent high-energy neutron scattering
experiments, which are damped at the momentum . We suggest that future
LCO neutron scattering experiments scan the energies between 450 meV and 566
meV and momenta around .Comment: 23 pages, 5 figure
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