Neurologic complications of HTLV-1: a review

The human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus that infects about 20 million people worldwide and causes immune--mediated diseases of the nervous system. The classical neurological presentation of HTLV-1 infection is the so-called HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). However, HAM/TSP is not the only neurological outcome that can result from HTLV-1 infection. In this Review it is made an update on the many aspects of this important neurological condition, the HTLV-1 neurological comple

Meningite recorrente de Mollaret: uma revisão

A meningite recorrente linfocítica benigna ou meningite de Mollaret, inicialmente descrita pelo neurologista francês Pierre Mollaret em 1944, é uma condição relativamente rara, benigna mas incapacitante durante os seus períodos de agudização. Trata-se de quadro inflamatório meníngeo recorrente devido a reativação de infecção pelo herpes simples vírus, particularmente o herpesvirus do tipo 2 (HSV-2). Pode ser reconhecida a partir do seu quadro clínico de meningismoagudo, perfil liquórico linfocítico e identificação do genoma viral por PCR no líquor. Aciclovir e seus derivados podem ser utilizado no seu tratamento ou na sua profilaxia. Sua identificação é importante no sentido de se excluir outras causas de quadros meníngeos recorrentes

Complicações neurológicas do HTLV: uma revisão HTLV-1

Submitted by Janaína Nascimento ([email protected]) on 2019-12-16T11:40:49Z No. of bitstreams: 1 ve_Araujo_Abelardo_INI_2019.pdf: 198640 bytes, checksum: 92fa7a22c23ba5f3813d2204d8a56bf5 (MD5)Approved for entry into archive by Janaína Nascimento ([email protected]) on 2019-12-16T11:57:06Z (GMT) No. of bitstreams: 1 ve_Araujo_Abelardo_INI_2019.pdf: 198640 bytes, checksum: 92fa7a22c23ba5f3813d2204d8a56bf5 (MD5)Made available in DSpace on 2019-12-16T11:57:06Z (GMT). No. of bitstreams: 1 ve_Araujo_Abelardo_INI_2019.pdf: 198640 bytes, checksum: 92fa7a22c23ba5f3813d2204d8a56bf5 (MD5) Previous issue date: 2019Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Neuroinfecções. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.The human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus that infects about 20 million people worldwide and causes immunemediated diseases of the nervous system. The classical neurological presentation of HTLV-1 infection is the so-called HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). However, HAM/TSP is not the only neurological outcome that can result from HTLV-1 infection. In this Review it is made an update on the many aspects of this important neurological condition, the HTLV-1 neurological complex.O vírus linfotrópico de células T humanas tipo 1 (HTLV-1) é um retrovírus que infecta cerca de 20 milhões de pessoas em todo o mundo e causa doenças imunomediadas do sistema nervoso. A apresentação neurológica clássica da infecção pelo HTLV-1 é a chamada paraparesia espástica tropical / mielopatia associada ao HTLV-1 (HAM/TSP). HAM / TSP,no entanto, não é o único desfecho neurológico que pode resultar da infecção pelo HTLV-1. Nesta revisão, é feita uma atualização sobre vários aspectos desta importante condição neurológica, o complexo neurológico do HTLV-1

Mollaret’s recurrent meningitis: an overview

Submitted by Janaína Nascimento ([email protected]) on 2019-12-16T12:06:39Z No. of bitstreams: 1 ve_Araujo_Abelardo_etal_INI_2019.pdf: 382413 bytes, checksum: 1b2724a8d09b82ef192dcc5ba436d907 (MD5)Approved for entry into archive by Janaína Nascimento ([email protected]) on 2019-12-16T12:13:40Z (GMT) No. of bitstreams: 1 ve_Araujo_Abelardo_etal_INI_2019.pdf: 382413 bytes, checksum: 1b2724a8d09b82ef192dcc5ba436d907 (MD5)Made available in DSpace on 2019-12-16T12:13:40Z (GMT). No. of bitstreams: 1 ve_Araujo_Abelardo_etal_INI_2019.pdf: 382413 bytes, checksum: 1b2724a8d09b82ef192dcc5ba436d907 (MD5) Previous issue date: 2019Fundação Oswaldo Cruz. Instituto Nacional de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.A meningite recorrente linfocítica benigna ou meningite de Mollaret, inicialmente descrita pelo neurologista francês Pierre Mollaret em 1944, é uma condição relativamente rara, benigna mas incapacitante durante os seus períodos de agudização. Trata-se de quadro inflamatório meníngeo recorrente devido a reativação de infecção pelo herpes simples vírus, particularmente o herpesvirus do tipo 2 (HSV-2). Pode ser reconhecida a partir do seu quadro clínico de meningismo agudo, perfil liquórico linfocítico e identificação do genoma viral por PCR no líquor. Aciclovir e seus derivados podem ser utilizado no seu tratamento ou na sua profilaxia. Sua identificação é importante no sentido de se excluir outras causas de quadros meníngeos recorrentes.Benign recurrent lymphocytic meningitis or Mollaret’s meningitis (MM) was first described by the French neurologist Pierre Mollaret in 1944. MM is a relatively rare, benign but disabling condition. MM is a recurrent meningeal inflammatory illness due to reactivation of herpes simplex virus infection, particularly herpesvirus type 2 (HSV2). It can be recognized from its clinical picture of acute meningism, lymphocytic CSF profile and by the identification of the viral genome in the CSF by PCR. Acyclovir and its derivatives may be used for its treatment or prophylaxis. The identification of MM is important in order to exclude other causes of recurrent meningeal conditions

Zika virus-associated neurological disorders: a review

We are grateful to Professor William W. Hall, MD, PhD (CRID, University College Dublin, Ireland) for his useful suggestions. We thank Dr. Lara Brandão, MD (Clinica Radiologica Felipe Mattoso, Rio de Janeiro, Brazil), for the MRI report of the microcephaly case.Submitted by Éder Freyre ([email protected]) on 2016-08-03T12:37:54Z No. of bitstreams: 1 INI - Zika virus-associated neurological disorders - a review.pdf: 318310 bytes, checksum: 798e79026fb1f1d9e32c3811e1ec5063 (MD5)Approved for entry into archive by Éder Freyre ([email protected]) on 2016-08-03T13:08:57Z (GMT) No. of bitstreams: 1 INI - Zika virus-associated neurological disorders - a review.pdf: 318310 bytes, checksum: 798e79026fb1f1d9e32c3811e1ec5063 (MD5)Made available in DSpace on 2016-08-03T13:08:57Z (GMT). No. of bitstreams: 1 INI - Zika virus-associated neurological disorders - a review.pdf: 318310 bytes, checksum: 798e79026fb1f1d9e32c3811e1ec5063 (MD5) Previous issue date: 2016Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Neuroinfecções. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Neurologia Deolindo Couto. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Neuroinfecções. Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Puericultura e Pediatria Martagão Gesteira. Rio de Janeiro, RJ, Brasil.Zika virus, an arbovirus transmitted by mosquitoes of the Aedes species, is now rapidly disseminating throughout the Americas and the ongoing Brazilian outbreak is the largest Zika virus epidemic so far described. In addition to being associated with a non-specific acute febrile illness, a number of neurological manifestations, mainly microcephaly and Guillain-Barré syndrome, have been associated with infection. These with other rarer neurological conditions suggest that Zika virus, similar to other flaviviruses, is neuropathogenic. The surge of Zika virus-related microcephaly cases in Brazil has received much attention and the role of the virus in this and in other neurological manifestations is growing. Zika virus has been shown to be transmitted perinatally and the virus can be detected in amniotic fluid, placenta and foetus brain tissue. A significant increase in Guillain-Barré syndrome incidence has also been reported during this, as well as in previous outbreaks. More recently, meningoencephalitis and myelitis have also been reported following Zika virus infection. In summary, while preliminary studies have suggested a clear relationship between Zika virus infection and certain neurological conditions, only longitudinal studies in this epidemic, as well as experimental studies either in animal models or in vitro, will help to better understand the role of the virus and the pathogenesis of these disorders