FEM ANALYSIS OF CORONARY STENT DEPLOYMENT

As stent technology moves forward, there’s a growing need for fast and accurate stent deployment visualizations. To that end, the Finite Element Method was used for quasi-static analysis of a balloon expandable stent. A model was created, which includes a stent, balloon, artery and a plaque. In order to achieve faster computation, various approximations have been included, especially considering the balloon, artery and plaque. Some non-linear problems are assessed, like the contact between different parts of the model. Arterial tissue and plaque are modeled as isotropic hyperelastic materials. The balloon was specially designed and discretized to avoid the computational difficulties during inflation. Thanks to the complexity of this model, useful results can be obtained in a reasonable time frame. The software used for FEM analysis was ABAQUS

Text messaging for visually impaired

This project is designed to help the visually impaired become a part of modern forms of communication. In this paper, we will present a hands-free device that is meant to be wirelessly connected to a smartphone through an accompanying app which will provide access to all forms of messengers and enable the user to send, listen, respond to a text message, etc. These many options have been made possible by combining the movement of different fingers, without the need of any kind of buttons or keyboards. The system is based on accelerometers and Morse code. It's easy to use, discreet and it also provides privacy, opposed to the voice input. So far, we have made a non-wireless device and programmed and tested it in LabView and Matlab

Text messaging for visually impaired

This project is designed to help the visually impaired become a part of modern forms of communication. In this paper, we will present a hands-free device that is meant to be wirelessly connected to a smartphone through an accompanying app which will provide access to all forms of messengers and enable the user to send, listen, respond to a text message, etc. These many options have been made possible by combining the movement of different fingers, without the need of any kind of buttons or keyboards. The system is based on accelerometers and Morse code. It's easy to use, discreet and it also provides privacy, opposed to the voice input. So far, we have made a non-wireless device and programmed and tested it in LabView and Matlab

Antimycobacterial and anticancer activity of newly designed cinnamic acid hydrazides with favorable toxicity profile

A series of twelve novel hybrids of cinnamic acid and thiocarbohydrazones were designed, synthesized in high yield using a simple coupling strategy via acid chlorides, and evaluated for their impact against Mycobacterium tuberculosis (Mtb) and cancer cells survival. Among them, compound 3 demonstrated strong anti-Mtb activity by reducing bacilli survival for>90 % in all three treated Mtb isolates, whereas isoniazid and rifampicin did not. Moreover, compound 3 didn't affect vitality of HepG-2 cells, implying on advantageous hepatotoxicity profile compared to current therapeutic options for tuberculosis. Compounds 2a and 3b displayed as strong inducers of apoptosis in A549 cells, both activating intrinsic caspase pathway and cell cycle arrest at the G0/ G1 phase. Subsequent analyses disclosed differences in their activities, where 3b has ability to induce production of mitochondrial superoxide anions, while 2a significantly inhibited cellular mobility. More importantly, 3b considerably affected viability of HepG-2 and HaCaT cells, whereas 2a had moderate impact only on the later. Molecular modeling studies indicated high permeability and good absorption through the human intestine, and moderate aqueous solubility with poor blood-brain barrier permeability. In summary, our results reveal that novel compounds 3 and 2a represent promising agents for tuberculosis and cancer treatment, respectively, indicating that fur-ther investigation needs to be performed to clarify the mechanisms of their anti-Mtb and anticancer activity. (c) 2021 The Authors. Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)