1 research outputs found
Investigation on the relationship between diabetes mellitus type 2 and cognitive impairment.
Objective: The incidence of cognitive impairment is increasing with age; however, little is
known about the role of hyperglycemia in cognitive impairment. This study focuses on
investigating the relationship between diabetes mellitus type 2 and cognitive impairment.
Methods: 60 diabetic patients, amongst whom, 30 had a well-controlled diabetes status and
the other 30 had not. These patients were compared to 60 non-diabetic controls whose age,
sex and educational class matched with the individuals of the first group. Patients with
important risk factors for cognitive disorders (renal failure, major depressive disorders and
psychoactive drug users, cerebrovascular accident history, etc.) were not included in the
study. Modified Mini Mental Status examination (mMMSE) was done for all patients by a
blinded expert examiner.
Results: Subjects with diabetes (n = 60) had lower MMSE score than those without diabetes
(P < .01). Diabetes was also associated with increased odds of cognitive decline as determined
by MMSE scores (odds ratio = 1.9; CI = 95%, 1.01–3.6). A significant correlation
between duration of disease and cognitive dysfunction was observed, P = 0.001. Also, the
same correlation was found for quality of diabetes control, P = 0.002.
Conclusion: Diabetes mellitus is associated with lower levels of cognitive functio