Production process aiming at the implementation of Cleaner Production in an industrial metalworking

Considering that companies are concerned with sustainable management in their production processes, it ir of importance to check the production processes in a metalworking industry, with an emphasis on the cleaner production process as a tool in business decision making. In this paper we propose the suggestion of a system of contínuos improvement using the cleaner production in the machinery departamento in a metalworking industry that produces agricultural implements in the north of Rio Grande do Sul. The participant observation method for the description of production processes with semi-structured interviews, with contente analysis as results. The use of this tool was satisfactory, since there was decrease of componentes in the production as raw material, and improvement in the productive processes. It should be noted that cleaner production generates savings in manufacturing processes, eliminating waste such as raw materials, waste, water and energy, generating financial and sustainable returns to companies

MiR-155 has a protective role in the development of non-alcoholic hepatosteatosis in mice

Hepatic steatosis is a global epidemic that is thought to contribute to the pathogenesis of type 2 diabetes. MicroRNAs (miRs) are regulators that can functionally integrate a range of metabolic and inflammatory pathways in liver. We aimed to investigate the functional role of miR-155 in hepatic steatosis. Male C57BL/6 wild-type (WT) and miR-155−/− mice were fed either normal chow or high fat diet (HFD) for 6 months then lipid levels, metabolic and inflammatory parameters were assessed in livers and serum of the mice. Mice lacking endogenous miR-155 that were fed HFD for 6 months developed increased hepatic steatosis compared to WT controls. This was associated with increased liver weight and serum VLDL/LDL cholesterol and alanine transaminase (ALT) levels, as well as increased hepatic expression of genes involved in glucose regulation (Pck1, Cebpa), fatty acid uptake (Cd36) and lipid metabolism (Fasn, Fabp4, Lpl, Abcd2, Pla2g7). Using miRNA target prediction algorithms and the microarray transcriptomic profile of miR-155−/− livers, we identified and validated that Nr1h3 (LXRα) as a direct miR-155 target gene that is potentially responsible for the liver phenotype of miR-155−/− mice. Together these data indicate that miR-155 plays a pivotal role regulating lipid metabolism in liver and that its deregulation may lead to hepatic steatosis in patients with diabetes

MICHEL FOUCAULT, A EDUCAÇÃO E O NEOLIBERALISMO

This papper seeks to think about the bases of a possible criticism undertaken by Michel Foucault around neoliberalism and its relationship with education. Based on a bibliographic survey that covers the works developed by Foucault from a political history of governmentality, we will try to demonstrate how neoliberalism, in Foucault's eyes, should be understood as a way of life and as a government practice responsible for the production of modes of subjectivation identified with self-entrepreneurship as the aesthetics of neoliberal existence. At first, we go through the contours of Foucault's thinking around a genealogy of the arts of government and of the processes of subjectification. The second moment is dedicated to trying to understand the effects by which neoliberalism is constituted as an ethos responsible for producing an experience of a capitalized and financialized education. Finally, our final considerations are dedicated to the elaboration of a critique around the neoliberal governmentality regime based on the contributions made by Michel Foucault.Nuestro artículo busca reflexionar sobre las bases de una posible crítica realizada por Michel Foucault en torno al neoliberalismo y su relación con la educación. A partir de un relevamiento bibliográfico que abarca los trabajos desarrollados por Foucault a partir de una historia política de la gubernamentalidad, intentaremos demostrar cómo el neoliberalismo, a los ojos de Foucault, debe entenderse como una forma de vida y como una práctica gubernamental responsable de la producción de modos. de subjetivación identificada con el autoemprendimiento como estética de la existencia neoliberal. En primer lugar, recorremos los contornos del pensamiento de Foucault en torno a una genealogía de las artes de gobierno y de los procesos de subjetivación. El segundo momento está dedicado a tratar de comprender los efectos por los cuales el neoliberalismo se constituye como un ethos responsable de producir una experiencia de educación capitalizada y financiarizada. Finalmente, nuestras consideraciones finales están dedicadas a la elaboración de una crítica en torno al régimen de gubernamentalidad neoliberal a partir de los aportes de Michel Foucault.This papper seeks to think about the bases of a possible criticism undertaken by Michel Foucault around neoliberalism and its relationship with education. Based on a bibliographic survey that covers the works developed by Foucault from a political history of governmentality, we will try to demonstrate how neoliberalism, in Foucault's eyes, should be understood as a way of life and as a government practice responsible for the production of modes of subjectivation identified with self-entrepreneurship as the aesthetics of neoliberal existence. At first, we go through the contours of Foucault's thinking around a genealogy of the arts of government and of the processes of subjectification. The second moment is dedicated to trying to understand the effects by which neoliberalism is constituted as an ethos responsible for producing an experience of a capitalized and financialized education. Finally, our final considerations are dedicated to the elaboration of a critique around the neoliberal governmentality regime based on the contributions made by Michel Foucault

Photosystem II inhibitors herbicides in pre-emergence control for crabgrass species

Muitas espécies do gênero Digitaria são denominadas de capim-colchão e ocorrem nas principais culturas agrícolas, com destaque para a cana-de-açúcar, a qual utiliza principalmente herbicidas inibidores do fotossistema II para o manejo de plantas daninhas. Devido à complexidade do sistema de cultivo e aos problemas atribuídos à substituição de espécies de plantas daninhas suscetíveis por espécies tolerantes de populações de capim-colchão, o trabalho teve como objetivo verificar o controle de espécies de capim-colchão utilizando herbicidas inibidores do fotossistema II (FSII), aplicados em pré-emergência. O experimento foi conduzido em casa de vegetação em esquema fatorial 3x7, com quatro repetições e em delineamento inteiramente ao acaso, com o primeiro fator compostos pelas três espécies de capim-colchão (D. ciliaris, D. horizontalis e D. nuda) e, o segundo, dos herbicidas utilizados (ametryn, hexazinone, amicarbazone, diuron + hexazinone, diuron e tebuthiuron), além da testemunha sem aplicação. A eficácia dos tratamentos foi verificada por meio de avaliação visual de controle aos 15 e 30 dias após a aplicação (DAA), análise do fluxo de elétrons do FSII e biomassa seca total da parte aérea das plantas. Para a D. nuda foi observada baixo controle com diuron e tebuthiuron. Os herbicidas ametryn, hexazinone, amicarbazone e a mistura de diuron + hexazinone foram eficazes no controle com níveis superiores a 95%, sendo alternativas no controle de plantas de capim-colchão.Many species of the genus Digitaria are known as crabgrass and occurs in the main agricultural crops, especially in sugarcane production, which uses mostly photosystem II inhibitor herbicides for weed management. Due to the complexity of the cultivation system and the problems attributed to the substitution of susceptible species weeds by tolerant species of crabgrass populations, the objective of this work was to verify the control of crabgrass species using photosystem II inhibitor herbicides (PSII) in pre-emergence. The experiment was conducted in greenhouse in a completely randomized in factorial scheme 3x7, with four replications, with the first factor composed of three crabgrass species (D. ciliaris, D. horizontalis and D. nuda) and the second factor composed of following herbicides (ametryn; hexazinone; amicarbazone; diuron + hexazinone; diuron and tebuthiuron), further of the treatment without application. . The efficacy of the treatments was verified through of control by visual evaluation at 15 and 30 days after application (DAA), PSII electron transport rate analysis and total dry biomass of aerial part of the plants. For D. nuda it was observed low control with the herbicides diuron and tebuthiuron. The herbicides ametryn, hexazinone, amicarbazone and diuron + hexazinone mixture were effective in the control with levels higher than 95%, being good alternatives in the crabgrass control

EP₂ receptor antagonism reduces peripheral and central hyperalgesia in a preclinical mouse model of endometriosis

Endometriosis is an incurable gynecological disorder characterized by debilitating pain and the establishment of innervated endometriosis lesions outside the uterus. In a preclinical mouse model of endometriosis we demonstrated overexpression of the PGE2-signaling pathway (including COX-2, EP2, EP4) in endometriosis lesions, dorsal root ganglia (DRG), spinal cord, thalamus and forebrain. TRPV1, a PGE2-regulated channel in nociceptive neurons was also increased in the DRG. These findings support the concept that an amplification process occurs along the pain neuroaxis in endometriosis. We then tested TRPV1, EP2, and EP4 receptor antagonists: The EP2 antagonist was the most efficient analgesic, reducing primary hyperalgesia by 80% and secondary hyperalgesia by 40%. In this study we demonstrate reversible peripheral and central hyperalgesia in mice with induced endometriosis