Overall strategy of the association study.

<p>Overall strategy of the association study.</p

Basic characteristics of case and control data in discovery phase.

<p>Abbreviation: Con: Control, Can: Oral cancer, Leu: Leukoplakia.</p>a<p>P-values from Mann-Whitney test,</p>b<p>p-values from chi-square test.</p

Allelic association results among different comparison groups.

a<p>MAF: Minor Allele Frequency of reference population is listed;</p>b<p>Association tests abbreviations, CC: case (jointly oral cancer and leukoplakia) vs. control, CAC: cancer vs. control, CAL: cancer vs. leukoplakia and LC: leukoplakia vs. control;</p>c<p>P-values without any adjustment for age, sex and tobacco habits by logistic regression and without any multiple tests correction applied,</p>d<p>P-values without any adjustment for age, sex and tobacco habits by logistic regression but corrected for multiple testing by Benjamini-Hochberg False Discovery Rate method,</p>e<p>P-values after adjustment for age, sex and tobacco habits by logistic regression but no correction multiple testing was applied,</p>f<p>P-values after adjustment for age, sex and tobacco habits by logistic regression and corrected for multiple testing by Benjamini-Hochberg False Discovery Rate method.</p

Allelic association results of replication study and comparison with discovery data.

a<p>MAF: Minor allele frequency of the reference population is listed;</p>*<p>Benjamini-Hochberg False Discovery Rate corrected P-values for multiple tests;</p>#<p>Unadjusted P-values.</p

Allelic associations in with respect to tobacco exposure.

a<p>MAF: Minor allele frequency of the reference population is listed;</p>b<p>Association tests abbreviations, CC: case (jointly oral cancer and leukoplakia) vs. Control, CAC: cancer vs. Control, CAL: cancer vs. Leukoplakia, LC: leukoplakia vs. control, HD: High-dose and LD: Low-dose tobacco exposed group;</p>c<p>Benjamini-Hochberg False Discovery Rate corrected P-values for multiple tests.</p

Basic characteristics of cancer and control in replication phase.

<p>Abbreviation:</p>a<p>p-values from Mann-Whitney test,</p>b<p>P-values from chi-square test.</p