189 research outputs found
Stroke incidence and 30-day case-fatality in a suburb of Tbilisi: results of the first prospective population-based study in Georgia
BACKGROUND AND PURPOSE: Although stroke is one of the main public health problems worldwide, no study of stroke incidence has been performed in Georgia, and therefore, a population-based registry was established to determine the incidence and case-fatality rates of first-ever stroke. METHODS: We identified all first-ever strokes between November 2000 and July 2003 in a defined population of 51,246 residents in the Sanzona suburb of Tbilisi, the capital of Georgia, using overlapping sources of information and standard diagnostic criteria. RESULTS: A total of 233 first-ever strokes occurred during the study period. The crude annual incidence rate was 165 (95% CI, 145 to 188) per 100,000 residents. The corresponding rate adjusted to the standard "world" population was 103 (95% CI, 89 to 117). In terms of stroke subtype, the crude annual incidence rate per 100,000 inhabitants was 89 (95% CI, 74 to 106) for ischemic stroke, 44 (95% CI, 34 to 57) for intracerebral hemorrhage, 16 (95% CI, 10 to 25) for subarachnoidal hemorrhage, and 16 (95% CI, 10 to 25) for unspecified stroke, and the corresponding case-fatality rates at 1 month were 19.2%, 48.4%, 47.8%, and 69.6%. CONCLUSIONS: The overall stroke incidence rate in an urban population of Georgia is comparable to those reported in developed countries. As for the stroke subtypes, there is an excess of hemorrhagic strokes compared with other registries. Geographical and lifestyle variations may explain these findings, whereas inadequacy of the stroke care system in Georgia might contribute to the high case-fatality. [Authors]]]>
Cerebrovascular Accident
oai:serval.unil.ch:BIB_31770
2022-05-07T01:14:25Z
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La résurrection du Christ dans les apocryphes.
Gounelle, R
info:eu-repo/semantics/bookPart
incollection
2004
Les premiers temps de l'Église. De saint Paul à saint Augustin (Folio Histoire 124), pp. 117-121
Baslez, M-F (ed.)
oai:serval.unil.ch:BIB_31771
2022-05-07T01:14:25Z
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https://serval.unil.ch/notice/serval:BIB_31771
Le Christ des apocryphes.
Gounelle, R
info:eu-repo/semantics/bookPart
incollection
2004
Les premiers temps de l'Église. De saint Paul à saint Augustin (Folio Histoire 124), pp. 242-245
Baslez, M-F (ed.)
oai:serval.unil.ch:BIB_31771256CC87
2022-05-07T01:14:25Z
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Cardiovascular disease, chronic kidney disease, and diabetes mortality burden of cardiometabolic risk factors from 1980 to 2010: a comparative risk assessment.
info:doi:10.1016/S2213-8587(14)70102-0
info:eu-repo/semantics/altIdentifier/doi/10.1016/S2213-8587(14)70102-0
info:eu-repo/semantics/altIdentifier/pmid/24842598
Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration
Danaei, G.
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Stevens, G.A.
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Farzadfar, F.
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Bovet, P.
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Broda, G.
Brown, I.J.
Bursztyn, M.
de León, A.C.
Campos, H.
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Capuano, V.
Casiglia, E.
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Craig, C.L.
Dankner, R.S.
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Delgado, E.
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info:eu-repo/semantics/article
article
2014-08</
Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan
Polycystic ovary syndrome (PCOS) is of clinical and public health importance as it is very common, affecting up to one in five women of reproductive age. It has significant and diverse clinical implications including reproductive (infertility, hyperandrogenism, hirsutism), metabolic (insulin resistance, impaired glucose tolerance, type 2 diabetes mellitus, adverse cardiovascular risk profiles) and psychological features (increased anxiety, depression and worsened quality of life). Polycystic ovary syndrome is a heterogeneous condition and, as such, clinical and research agendas are broad and involve many disciplines. The phenotype varies widely depending on life stage, genotype, ethnicity and environmental factors including lifestyle and bodyweight. Importantly, PCOS has unique interactions with the ever increasing obesity prevalence worldwide as obesity-induced insulin resistance significantly exacerbates all the features of PCOS. Furthermore, it has clinical implications across the lifespan and is relevant to related family members with an increased risk for metabolic conditions reported in first-degree relatives. Therapy should focus on both the short and long-term reproductive, metabolic and psychological features. Given the aetiological role of insulin resistance and the impact of obesity on both hyperinsulinaemia and hyperandrogenism, multidisciplinary lifestyle improvement aimed at normalising insulin resistance, improving androgen status and aiding weight management is recognised as a crucial initial treatment strategy. Modest weight loss of 5% to 10% of initial body weight has been demonstrated to improve many of the features of PCOS. Management should focus on support, education, addressing psychological factors and strongly emphasising healthy lifestyle with targeted medical therapy as required. Monitoring and management of long-term metabolic complications is also an important part of routine clinical care. Comprehensive evidence-based guidelines are needed to aid early diagnosis, appropriate investigation, regular screening and treatment of this common condition. Whilst reproductive features of PCOS are well recognised and are covered here, this review focuses primarily on the less appreciated cardiometabolic and psychological features of PCOS
PREVALENCE OF NON-ALCOHOLIC FATTY LIVER DISEASE IN WOMEN WITH POLYCYSTIC OVARY SYNDROME AND ITS CORRELATION WITH METABOLIC SYNDROME
Investigation of the Mechanism of Changes of RS Character of Neurovaccine in Passages in the Presence of Bromodeoxyuridine
Greek hyperinsulinemic women, with or without polycystic ovary syndrome, display altered inositols metabolism
BACKGROUND: We have shown that American women with polycystic ovary
syndrome (PCOS) have decreased glucose-stimulated release of a putative
mediator of insulin action, D-chiro-inositol (DCI)-containing
inositolphosphoglycan (DCI-IPG), and increased urinary clearance of DCI
(uCl(DCI)), which was associated with hyperinsulinemia. METHODS: DCI
levels and the release of insulin and DCI-IPG during an oral glucose
tolerance test (AUCs) were assessed in 27 Greek PCOS and 10 normal Greek
women. RESULTS: PCOS women were heavier than controls (BMI = 28.4 versus
23.7 kg/m(2), P = 0.05) with higher waist-to-hip ratios (WHR = 0.78
versus 0.71, P = 0.009) and increased free testosterone (P = 0.048) and
AUC(insulin) (P = 0.04). In PCOS women, incremental AUC(DCI-IPG) was
significantly decreased by 59% (2158 versus 5276%.min, P = 0.01), even
after correction for BMI and WHR. Finally, increased uCl(DCI) (r = 0.35,
P = 0.04) and decreased AUC(DCI-IPG) (r = 0.46, P = 0.004) were
significantly associated with hyperinsulinemia in all women together,
even after correction for BMI and WHR (Ps = 0.02 and 0.007), and
regardless of PCOS status. CONCLUSION: Greek women, with or without
PCOS, display increased uCl(DCI) and decreased AUC(DCI-IPG) in
association with higher insulin levels but independent of adiposity.
Increased clearance of inositols might reduce tissue availability of DCI
and decrease the release of DCI-IPG mediator, which could contribute to
insulin resistance and compensatory hyperinsulinemia in Greek women, as
previously described in American women
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