4,925 research outputs found
Observation of quantum spin noise in a 1D light-atoms quantum interface
We observe collective quantum spin states of an ensemble of atoms in a
one-dimensional light-atom interface. Strings of hundreds of cesium atoms
trapped in the evanescent fiel of a tapered nanofiber are prepared in a
coherent spin state, a superposition of the two clock states. A weak quantum
nondemolition measurement of one projection of the collective spin is performed
using a detuned probe dispersively coupled to the collective atomic observable,
followed by a strong destructive measurement of the same spin projection. For
the coherent spin state we achieve the value of the quantum projection noise 40
dB above the detection noise, well above the 3 dB required for reconstruction
of the negative Wigner function of nonclassical states. We analyze the effects
of strong spatial inhomogeneity inherent to atoms trapped and probed by the
evanescent waves. We furthermore study temporal dynamics of quantum
fluctuations relevant for measurement-induced spin squeezing and assess the
impact of thermal atomic motion. This work paves the road towards observation
of spin squeezed and entangled states and many-body interactions in 1D spin
ensembles
Generation and detection of a sub-Poissonian atom number distribution in a one-dimensional optical lattice
We demonstrate preparation and detection of an atom number distribution in a
one-dimensional atomic lattice with the variance dB below the Poissonian
noise level. A mesoscopic ensemble containing a few thousand atoms is trapped
in the evanescent field of a nanofiber. The atom number is measured through
dual-color homodyne interferometry with a pW-power shot noise limited probe.
Strong coupling of the evanescent probe guided by the nanofiber allows for a
real-time measurement with a precision of atoms on an ensemble of some
atoms in a one-dimensional trap. The method is very well suited for
generating collective atomic entangled or spin-squeezed states via a quantum
non-demolition measurement as well as for tomography of exotic atomic states in
a one-dimensional lattice
Binary pattern tile set synthesis is NP-hard
In the field of algorithmic self-assembly, a long-standing unproven
conjecture has been that of the NP-hardness of binary pattern tile set
synthesis (2-PATS). The -PATS problem is that of designing a tile assembly
system with the smallest number of tile types which will self-assemble an input
pattern of colors. Of both theoretical and practical significance, -PATS
has been studied in a series of papers which have shown -PATS to be NP-hard
for , , and then . In this paper, we close the
fundamental conjecture that 2-PATS is NP-hard, concluding this line of study.
While most of our proof relies on standard mathematical proof techniques, one
crucial lemma makes use of a computer-assisted proof, which is a relatively
novel but increasingly utilized paradigm for deriving proofs for complex
mathematical problems. This tool is especially powerful for attacking
combinatorial problems, as exemplified by the proof of the four color theorem
by Appel and Haken (simplified later by Robertson, Sanders, Seymour, and
Thomas) or the recent important advance on the Erd\H{o}s discrepancy problem by
Konev and Lisitsa using computer programs. We utilize a massively parallel
algorithm and thus turn an otherwise intractable portion of our proof into a
program which requires approximately a year of computation time, bringing the
use of computer-assisted proofs to a new scale. We fully detail the algorithm
employed by our code, and make the code freely available online
Hyperfine interaction and electronic spin fluctuation study on SrLaFeCoO (x = 0, 1, 2) by high-resolution back-scattering neutron spectroscopy
The study of hyperfine interaction by high-resolution inelastic neutron
scattering is not very well known compared to the other competing techniques
viz. NMR, M\"ossbauer, PACS etc. Also the study is limited mostly to
magnetically ordered systems. Here we report such study on
SrLaFeCoO (x = 0, 1, 2) of which first (SrFeCoO with x
= 0) has a canonical spin spin glass, the second (SrLaFeCoO with x = 1) has
a so-called magnetic glass and the third (LaFeCoO with x = 2) has a
magnetically ordered ground state. Our present study revealed clear inelastic
signal for SrLaFeCoO, possibly also inelastic signal for SrFeCoO
below the spin freezing temperatures but no inelastic signal at all
for for the magnetically ordered LaFeCoO in the neutron scattering
spectra. The broadened inelastic signals observed suggest hyperfine field
distribution in the two disordered magnetic glassy systems and no signal for
the third compound suggests no or very small hyperfine field at the Co nucleus
due to Co electronic moment. For the two magnetic glassy system apart from the
hyperfine signal due only to Co, we also observed electronic spin fluctuations
probably from both Fe and Co electronic moments. \end{abstract
Treatment of nephrotic syndrome with adrenocorticotropic hormone (ACTH) gel
Andrew S Bomback1, James A Tumlin2, Joel Baranski3, James E Bourdeau4, Anatole Besarab5, Alice S Appel1, Jai Radhakrishnan1, Gerald B Appel11Department of Medicine, Division of Nephrology, Columbia University College of Physicians and Surgeons, New York, NY, USA; 2Department of Internal Medicine, Division of Nephrology, University of Tennessee College of Medicine in Chattanooga, Chattanooga, TN, USA; 3Balboa Nephrology Medical Group, San Diego, CA, USA; 4Nephrology Specialists of Oklahoma, Tulsa, OK, USA; 5Department of Medicine, Division of Nephrology and Hypertension, Henry Ford Health System, Detroit, MI, USAPurpose: A synthetic adrenocorticotropin (ACTH) analog has shown efficacy in Europe as primary and secondary therapy for nephrotic syndrome, but there is no published experience using the natural, highly purified ACTH gel formulation, available in the United States, for nephrotic syndrome. We therefore investigated the use of ACTH gel for nephrotic syndrome in the United States.Patients and methods: Twenty-one patients with nephrotic syndrome treated with ACTH gel outside of research settings in the United States, with initiation of therapy by December 31, 2009, allowing a minimum 6 months follow-up. We defined complete remission as stable renal function with proteinuria falling to <500 mg/day, and partial remission as stable renal function with >50% reduction in proteinuria from 500 to 3500 mg/day.Results: Twenty-one patients with nephrotic syndrome were treated: 11 with idiopathic membranous nephropathy (iMN), 4 with membranoproliferative glomerulonephritis (MPGN), 1 with focal segmental glomerulosclerosis (FSGS), 1 with minimal change disease (MCD), 1 with immunoglobulin A (IgA) nephropathy, 1 with class V systemic lupus erythematosus (SLE) glomerulonephritis, 1 with monoclonal diffuse proliferative glomerulonephritis, and 1 with unbiopsied nephrotic syndrome. ACTH was used as primary therapy for 3 patients; the remaining patients had previously failed a mean 2.3 immunosuppressive regimens. Eleven patients achieved a complete or partial remission, with 4 (19%) in complete remission. Of the 11 patients who achieved remission, 9 had iMN, 1 had FSGS, and 1 had IgA nephropathy. Of the 11 patients with iMN, 3 (27%) achieved complete remission and 6 (55%) achieved partial remission despite having previously failed a mean 2.4 therapies. Five patients reported steroid-like adverse effects, but there were no severe infections. The limitations were retrospective data analysis with short-term follow-up.Conclusion: ACTH gel may be a viable treatment option for resistant nephrotic syndrome due to membranous nephropathy. Short-term data suggest that remission rates may approach 80%.Keywords: nephrotic syndrome, membranous nephropathy, chronic kidney diseas
Symposium in Celebration of the Fixed Target Program with the Tevatron
This document is an abridgement of the commemorative book prepared on the occasion of the symposium "In Celebration of the Fixed Target Program with the Tevatron" held at Fermilab on June 2, 2000. The full text with graphics contains, in addition to the material here, a section for each experiment including a "plain text" description, lists of all physics publications, lists of all degree recipients and a photo from the archives. The full text is available on the web at: http://conferences.fnal.gov/tevft/book
- …