The social impacts of stormwater management techniques

This paper presents the results of research into the social impacts of stormwater management techniques applied within urban environments. The main aim of the study was to compare public and professional attitudes of stormwater management practices such as Sustainable Urban Drainage Systems (SUDS) and river management techniques. Any new and innovative technology used in residential areas, besides being economically and environmentally acceptable, must also be accepted by the residents. There has been considerable interest in the assessment of the public perception of SUDS in the UK by consultants, developers, the Environment Agency of England and Wales as well as by the Scottish Environment Protection Agency (SEPA). This research was undertaken to inform such interest and also to obtain a more holistic view of the perception by professionals of SUDS. A comparative study of the perceptions of river management in three densely populated European cities facing similar storm water management problems was carried out. The selected cities were Glasgow in Scotland – U. K., an area in west London, England - U.K., and part of Athens – Greece. All sites were located within flood-prone suburban areas, and different river management techniques have been proposed or adopted

The link between ecosystem services and human wellbeing in the implementation of the European Water Framework Directive: assessing four river basins in Europe.

This paper explores the relationship between the environment and human wellbeing whilst considering water resource pressures in the context of ecosystem services, before assessing the management actions to facilitate human wellbeing under the European Union’s Water Framework Directive (WFD). By focusing on four river basins in four European countries currently working to implement the WFD, we explore the effects of multiple pressures faced within each one on human wellbeing. Under an Ecosystem Services framework, we identify those effects and consolidate them into Human Wellbeing Factors to assess the management actions. Then, by conducting a qualitative content analysis, we assess the effectiveness of each Program of Measures at river basin level and relate them to Human Wellbeing Factors. Findings indicate that factors such as population growth trends intensify the effects of these pressures on human wellbeing. Finally, the paper pinpoints that human wellbeing must remain an ever-present consideration to be weighed against any other competing policy objectives

Assessing the effectiveness of the WFD as a tool to address different levels of water scarcity based on two case studies of the Mediterranean region.

Despite being a natural phenomenon, water scarcity is, to a great extent, human-induced, particularly affected by climate change and by the increased water resources vulnerability. The Water Framework Directive (WFD), an ‘umbrella’ directive that aims to provide holistic approaches to the management of water resources and is supported by a number of Communication documents on water scarcity, requires for prompt responses to ensure ‘healthy’ water bodies of good ecological status. The current paper presents a multidisciplinary approach, developed and engaged within the Globaqua Project, to provide an assessment of the main challenges towards addressing water scarcity with emphasis on the climate change projections, in two Mediterranean regions. The current paper attempts to critically assess the effectiveness of the WFD as a tool to address water scarcity and increase sustainability in resource use. Criticism lies on the fact that the WFD does not directly refer to it, still, water scarcity is recognized as a factor that increases stress on water resources and deteriorates their status. In addition, the Program of Measures (PoMs) within the WFD clearly contribute to reducing vulnerability of water resources and to ensure current and future water use, also under the impact of the projected climate change

International study on inter-reader variability for circulating tumor cells in breast cancer

Introduction Circulating tumor cells (CTCs) have been studied in breast cancer with the CellSearch® system. Given the low CTC counts in non-metastatic breast cancer, it is important to evaluate the inter-reader agreement. Methods CellSearch® images (N = 272) of either CTCs or white blood cells or artifacts from 109 non-metastatic (M0) and 22 metastatic (M1) breast cancer patients from reported studies were sent to 22 readers from 15 academic laboratories and 8 readers from two Veridex laboratories. Each image was scored as No CTC vs CTC HER2- vs CTC HER2+. The 8 Veridex readers were summarized to a Veridex Consensus (VC) to compare each academic reader using % agreement and kappa (κ) statistics. Agreement was compared according to disease stage and CTC counts using the Wilcoxon signed rank test. Results For CTC definition (No CTC vs CTC), the median agreement between academic readers and VC was 92% (range 69 to 97%) with a median κ of 0.83 (range 0.37 to 0.93). Lower agreement was observed in images from M0 (median 91%, range 70 to 96%) compared to M1 (median 98%, range 64 to 100%) patients (P < 0.001) and from M0 and <3CTCs (median 87%, range 66 to 95%) compared to M0 and ≥3CTCs samples (median 95%, range 77 to 99%), (P < 0.001). For CTC HER2 expression (HER2- vs HER2+), the median agreement was 87% (range 51 to 95%) with a median κ of 0.74 (range 0.25 to 0.90). Conclusions The inter-reader agreement for CTC definition was high. Reduced agreement was observed in M0 patients with low CTC counts. Continuous training and independent image review are require

Central nervous system relapse in patients with breast cancer is associated with advanced stages, with the presence of circulating occult tumor cells and with the HER2/neu status

INTRODUCTION: To evaluate the incidence of central nervous system (CNS) involvement in patients with breast cancer treated with a taxane-based chemotherapy regimen and to determine predictive factors for CNS relapse. METHODS: The medical files of patients with early breast cancer (n = 253) or advanced stage breast cancer (n = 239) as well of those with other solid tumors (n = 336) treated with or without a taxane-based chemotherapy regimen during a 42-month period were reviewed. HER2/neu overexpression was identified by immunohistochemistry, whereas cytokeratin 19 (CK-19) mRNA-positive circulating tumor cells (CTCs) in the peripheral blood were identified by real-time PCR. RESULTS: The incidence of CNS relapse was similar in patients suffering from breast cancer or other solid tumors (10.4% and 11.4%, respectively; P = 0.517). The incidence of CNS relapse was significantly higher in breast cancer patients with advanced disease (P = 0.041), visceral disease and bone disease (P = 0.036), in those who were treated with a taxane-containing regimen (P = 0.024), in those with HER2/neu-overexpressing tumors (P = 0.022) and, finally, in those with detectable CK-19 mRNA-positive CTCs (P = 0.008). Multivariate analysis revealed that the stage of disease (odds ratio, 0.23; 95% confidence interval, 0.007–0.23; P = 0.0001), the HER2/neu status (odds ratio, 29.4; 95% confidence interval, 7.51–101.21; P = 0.0001) and the presence of CK-19 mRNA-positive CTCs (odds ratio, 8.31; 95% confidence interval, 3.97–12.84; P = 0.001) were independent predictive factors for CNS relapse. CONCLUSION: CNS relapses are common among breast cancer patients treated with a taxane-based chemotherapy regimen, patients with HER2/neu-positive tumor and patients with CK-19 mRNA-positive CTCs

Travaux menés en collaboration avec l’Ecole française d’Athènes en 2004: Itanos (Crète orientale)

info:eu-repo/semantics/publishe