52 research outputs found

    Central urban space as a hybrid common infrastructure

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    In this paper we document and reflect on an ongoing co-design process of a new urban space, by the name L200, located in a very central and precious location in Zurich. L200 has the characteristics of an urban node at the confluence of many networks, a hub like railway stations provide these days but at a different spatial scale, acting as a much needed infrastructure for various commoning activities, among others. L200 is designed as a hybrid space, hosting a DIY digital platform, which is being co-created as a commons itself through a long-term participatory process and provides a building block for an alternative, bottom-up, vision to the “smart city”. In terms of participatory design, we experiment with, and advocate for, a structured laissez-faire methodology that frames both the physical and digital space as interconnected common infrastructures that the members of the association are free to use “as if it was their own” for limited periods of time. This participation through action approach allows for needs, ideas, and interventions to manifest naturally without any pressure or expectations. This means that the corresponding research for producing tools, methodologies, and designs need to advance in a slower than usual pace, and integrate many perspectives that use different languages and have different priorities. This slow design process allows for various forms of peer learning to occur. The paper lays out the overall L200 project in its full complexity through the dual role assumed by the authors, as researchers and activists, highlighting specific decisions, actions, and methodologies that contribute to the on-going research on infrastructuring the commons

    Sinteza, caracterizarea şi evaluarea fitobiologică a unei noi 2-[4-(4-bromofenilsulfonil) fenil]-4-metiloxazol - 5(4H)-one şi a unor noi 5-aril -2-[4-(4-bromofenilsulfonil) fenil]- 4-metiloxazoli

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    “Carol Davila“ University of Medicine and Pharmacy, Faculty of Pharmacy, Bucharest, Romania, Romanian Academy, “Costin D. Nenitescu“ Centre of Organic Chemistry, Bucharest, RomaniaPurpose. Heterocyclic compounds containing 1,3-oxazol-5(4H)-one and 1,3-oxazole ring are important targets in synthetic and medicinal chemistry, because of their applications as potentially active compounds. Thus, some 1,3-oxazol-5(4H)-ones have been reported to present antimicrobial and antitumor activity. 1,3-Oxazoles are frequent substructures in various biologically active compounds used in therapeutics as anti-inflammatory (e.g. Oxaprozin, Romazarit, Ditazol, Isamoxole), analgesic (e.g. Oxaprozin), antibacterial, antifungal (e.g. Sulfamoxole, Sulfaguanole), muscle relaxant (e.g. Azumolene) drugs. Therefore, there is considerable interest to synthesize new 1,3-oxazole- 5(4H)-ones and 1,3-oxazoles which contain 4-(4-bromophenylsulfonyl) phenyl moiety in 2 position with a hope to obtain potent biologically active compounds. The plant growth regulatory effects of the new compounds were examined. Material and Methods. By Steiger N-acylation of α-alanine with 4-(4-bromophenylsulfonyl)benzoyl chloride at cool afforded 2-[4-(4-bromophenylsulfonyl) benzamido] propanoic acid. This compound underwent intramolecular cyclization in the presence of N-methylmorpholine and ethyl chloroformate or acetic anhydride to the corresponding saturated azlactone. Then, acylaminoacylation of dry aromatic hydrocarbons (benzene, toluene, m-xylene, mesitylene) with 2-[4-(4-bromophenylsulfonyl)phenyl]-4- methyloxazol-5(4H)-one or 2-[4-(4-bromophenylsulfonyl) benzamido]propanoyl chloride in the presence of anhydrous aluminum chloride led to N-(1-aryl-1- oxopropan-2-yl)-4-(4-bromophenylsulfonyl)benzamides. These new intermediates were heterocyclized under the action of phosphorus oxychloride or concentrated sulfuric acid in the presence of acetic anhydride in ethyl acetate to the corresponding 5-aryl-2-[4- (4-bromophenylsulfonyl)phenyl]-4-methyloxazoles. The structure of new compounds was confirmed by elemental analysis and different spectral methods (FT-IR, UV, MS, 1H- and 13C-NMR). The purity of the compounds was evaluated by RP-HPLC. The new compounds have been investigated for their biological activities in the growth regulation of wheat, using the phytobiological method, known as the Constantinescu bioassay – Triticum test. Results. Ten new compounds were synthesized and characterized in orther to evaluate their biological activity. The preliminary results indicated that the tested compounds exhibited a weak stimulatory activity, except of α-acylaminoketones. Conclusions. In conclusion, in this paper we described the synthesis, characterization and phytobiological activity of ten new compounds possessing the 4-(4-bromophenylsulfonyl)phenyl moiety

    Urbanity and the Right to Difference

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