A state-of-the-art analysis of the dwarf irregular galaxy NGC 6822

We present a detailed photometric study of the dwarf irregular galaxy NGC 6822 aimed at investigating the properties of its stellar populations and, in particular, the presence of stellar radial gradients. Our goal is to analyse the stellar populations in six fields, which cover the whole bar of this dwarf galaxy. We derived the quantitative star formation history (SFH) of the six fields using the IAC method, involving IAC-pop/MinnIAC codes. The solutions we derived show an enhanced star formation rate (SFR) in Fields 1 and 3 during the past 500 Myr. The SFRs of the other fields are almost extinguished at very recent epochs and. We study the radial gradients of the SFR and consider the total mass converted into stars in two time intervals (between 0 and 0.5 Gyr ago and between 0.5 and 13.5 Gyr ago). We find that the scale lengths of the young and intermediate-to-old populations are perfectly compatible, with the exception of the young populations in Fields 1 and 3. The recent SF in these two fields is greater than in the other ones. This might be an indication that in these two fields we are sampling incipient spiral arms. Further evidence and new observations are required to prove this hypothesis. In addition, we derived the age-metallicity relations. As expected, the metallicity increases with time for all of the fields. We do not observe any radial gradient in the metallicity.Comment: 9 pages, 11 figures, Accepted to A&

Rotation of Hot Horizontal Branch Stars in the Globular Clusters NGC 1904, NGC 2808, NGC 6093 and NGC 7078

We present high resolution UVES+VLT spectroscopic observations of 56 stars in the extended horizontal branch (EHB) of the Galactic globular clusters NGC 1904, NGC 2808, NGC 6093, and NGC 7078. Our data reveal for the first time the presence in NGC 1904 of a sizable population of fast (vsini > 20 km/s) horizontal branch (HB) rotators, confined to the cool end of the EHB, similar to that found in M13. We also confirm the fast rotators already observed in NGC 7078. The cooler stars (Teff < 11,500 K) in these three clusters show a range of rotation rates, with a group of stars rotating at ~ 15 km/s or less, and a fast rotating group at ~ 30 km/s. Apparently, the fast rotators are relatively more abundant in NGC 1904 and M13, than in NGC 7078. No fast rotators have been identified in NGC 2808 and NGC 6093. All the stars hotter than Teff ~ 11,500 K have projected rotational velocities vsini < 12 km/s, but less than 20% have vsini < 2 km/s. The connection between photometric gaps in the HB and the change in the projected rotational velocities is not confirmed by the new data. However, our data are consistent with a relation between this discontinuity and the HB jump. We discuss a number of possibilities for the origin of the stellar rotation distribution along the HB. We conclude that none of them can yet provide a satisfactory explanation of the observations.Comment: 12 pages, 3 figures, ApJ Letter, accepte

Spatially resolved LMC star formation history: I. Outside in evolution of the outer LMC disk

We study the evolution of three fields in the outer LMC disk Rgc=3.5-6.2 Kpc. Their star formation history indicates a stellar populations gradient such that younger stellar populations are more centrally concentrated. We identify two main star forming epochs, separated by a period of lower activity between ~7 and ~4 Gyr ago. Their relative importance varies from a similar amount of stars formed in the two epochs in the innermost field, to only 40% of the stars formed in the more recent epoch in the outermost field. The young star forming epoch continues to the present time in the innermost field, but lasted only till ~0.8 and 1.3 Gyr ago at Rgc=5.5 degrees and 7.1 degrees, respectively. This gradient is correlated with the measured HI column density and implies an outside-in quenching of the star formation, possibly related to a variation of the size of the HI disk. This could either result from gas depletion due to star formation or ram-pressure stripping, or from to the compression of the gas disk as ram-pressure from the Milky Way halo acted on the LMC interstellar medium. The latter two situations may have occurred when the LMC first approached the Milky Way.Comment: 15 pages, 13 figures, 4 tables. MNRAS, in pres

Plasmodium falciparum glutamate dehydrogenase a is dispensable and not a drug target during erythrocytic development

&lt;p&gt;Background: Plasmodium falciparum contains three genes encoding potential glutamate dehydrogenases. The protein encoded by gdha has previously been biochemically and structurally characterized. It was suggested that it is important for the supply of reducing equivalents during intra-erythrocytic development of Plasmodium and, therefore, a suitable drug target.&lt;/p&gt; &lt;p&gt;Methods: The gene encoding the NADP(H)-dependent GDHa has been disrupted by reverse genetics in P. falciparum and the effect on the antioxidant and metabolic capacities of the resulting mutant parasites was investigated.&lt;/p&gt; &lt;p&gt;Results: No growth defect under low and elevated oxygen tension, no up-or down-regulation of a number of antioxidant and NADP(H)-generating proteins or mRNAs and no increased levels of GSH were detected in the D10(Delta gdha) parasite lines. Further, the fate of the carbon skeleton of [(13)C] labelled glutamine was assessed by metabolomic studies, revealing no differences in the labelling of a-ketoglutarate and other TCA pathway intermediates between wild type and mutant parasites.&lt;/p&gt; &lt;p&gt;Conclusions: First, the data support the conclusion that D10(Delta gdha) parasites are not experiencing enhanced oxidative stress and that GDHa function may not be the provision of NADP(H) for reductive reactions. Second, the results imply that the cytosolic, NADP(H)-dependent GDHa protein is not involved in the oxidative deamination of glutamate but that the protein may play a role in ammonia assimilation as has been described for other NADP(H)dependent GDH from plants and fungi. The lack of an obvious phenotype in the absence of GDHa may point to a regulatory role of the protein providing glutamate (as nitrogen storage molecule) in situations where the parasites experience a limiting supply of carbon sources and, therefore, under in vitro conditions the enzyme is unlikely to be of significant importance. The data imply that the protein is not a suitable target for future drug development against intra-erythrocytic parasite development.&lt;/p&gt

Attracting the Entrepreneurial Potential: A Multilevel Institutional Approach

The research on institutions’ role in entrepreneurship acknowledges that formal and informal institutions matter. However, previous research has stressed less the co-existence and interaction between individual- and country-level factors that shape entrepreneurial potential, population of skill-full individuals with no entrepreneurial intentions, across countries. In this study, we investigate the multilevel influence of informal institutions on entrepreneurial potential. Drawing from institutional theory and multilevel approach in a sample of 880,576 individuals for the period 2006–2016, we find that the informal country-level institutional forces compensate the lack of individual-level factors among those with low entrepreneurial potential. For instance, media coverage on entrepreneurship or education can enhance the entrepreneurial potential in its lower end. Hence, our findings provide novel evidence on the relevance and interaction of the informal institutions among potential entrepreneurs. Our findings suggest policy implications regarding educational programs to close the gap between entrepreneurially skilled non-potential and skilled potential individual