In silico Proteome-wide Amino aCid and Elemental Composition (PACE) Analysis of Expression Proteomics Data Provides A Fingerprint of Dominant Metabolic Processes

AbstractProteome-wide Amino aCid and Elemental composition (PACE) analysis is a novel and informative way of interrogating the proteome. The PACE approach consists of in silico decomposition of proteins detected and quantified in a proteomics experiment into 20 amino acids and five elements (C, H, N, O and S), with protein abundances converted to relative abundances of amino acids and elements. The method is robust and very sensitive; it provides statistically reliable differentiation between very similar proteomes. In addition, PACE provides novel insights into proteome-wide metabolic processes, occurring, e.g., during cell starvation. For instance, both Escherichia coli and Synechocystis down-regulate sulfur-rich proteins upon sulfur deprivation, but E. coli preferentially down-regulates cysteine-rich proteins while Synechocystis mainly down-regulates methionine-rich proteins. Due to its relative simplicity, flexibility, generality and wide applicability, PACE analysis has the potential of becoming a standard analytical tool in proteomics

A Systematic Review On Traditional Use, Phytochemical And Pharmacological Properties Of Some Medicinal Plants Growing In Kurdistan Region – Iraq

Many products labeled as "traditional herbal remedies" have a lengthy history of usage by definition of the term "traditional." Large segments of the population in many developing countries rely on traditional healers and their arsenal of medicinal plants to meet their healthcare requirements. Because of historical and cultural factors, herbal treatments are still widely used in modern medicine despite their antiquity. In industrialized nations, such things have become more accessible commercially. Current medical systems frequently recommend using chemicals in ways they weren't designed to be used. In certain parts of the world, the manufacture of herbal medicines are subjected to tight regulations, but this is not the case in other parts. In Germany Pharmacological goods are bound to the same criteria of efficacy, safety, and quality as herbal remedies, they are sold as "phytomedicines. On the other hand, most herbal products are marketed and monitored as food supplements in the United States, no pre-approval is required for this product category in the United Kingdom. As numerous academics in Iraq and the Kurdistan area have indicated, herbs have been utilized as a traditional cure for a wide range of illnesses in the past. Tribulus terrestris, Artemisia splendens Willd, Crataegus azarolus, Teucrium chamaedrys, Adiantum capillus-veneris and Matricaria chamomilla are the herbs discussed in this study, and their medicinal and traditional usage across the world, as well as some of the chemical components in these herbs' biological activity, are discussed