Bionanomedicine: A “Panacea” In Medicine?

Recent advances in nanotechnology, biotechnology, bioinformatics, and materials science have prompted novel developments in the field of nanomedicine. Enhancements in the theranostics, computational information, and management of diseases/disorders are desperately required. It may now be conceivable to accomplish checked improvements in both of these areas utilising nanomedicine. This scientific and concise review concentrates on the fundamentals and potential of nanomedicine, particularly nanoparticles and their advantages, nanoparticles for siRNA conveyance, nanopores, nanodots, nanotheragnostics, nanodrugs and targeting mechanisms, and aptamer nanomedicine. The combination of various scientific fields is quickening these improvements, and these interdisciplinary endeavours to have significant progressively outstretching influences on different fields of research. The capacities of nanomedicine are immense, and nanotechnology could give medicine a completely new standpoint

Cancer Stem Cells

This mini-review will discuss Cancer Stem Cells (CSCs) on their definition, history, characteristics, models, origin, tumorigenesis, targeting Cancer Stem Cells with nanomaterials, niche interactions, CSCs therapeutics, vaccination, the role of autophagy in CSCs, artificial intelligence, and clinical trials targeting CSCs. Mini review ini membahas sel punca kanker (Cancer Stem Cells), meliputi: definisi, sejarah, karakteristik, model, asal-mula, tumorigenesis, menarget CSCs dengan nanomaterial, interaksi niche, terapeutik berbasis CSCs, vaksinasi, peran autofagi pada CSCs, kecerdasan buatan, dan uji klinik menarget CSCs

Tension-Type Headache

Nyeri kepala tegang otot (tension-type headache -TTH) adalah nyeri kepala yang paling umum di seluruh dunia. Penulisan ilmiah ini bertujuan untuk mereview publikasi terkini yang terkait dengan TTH. Review ini berfokus pada pembahasan epidemiologi, etiopatofisiologi, potret klinis, pemeriksaan (fisik dan penunjang), penatalaksanaan, diagnosis banding, komorbiditas, pencegahan, dan prognosis.Tension-type headaches (TTH) are very common headache worldwide. The objective of this scientific paper was to review the recent and relevant publication about tension-type headache. This review focuses on epidemiology, etiopathophysiology, clinical portrait, physical examination and additional assessment, management, differential diagnosis, comorbidity, preventive, and prognosis in TTH

Neurophenomenology of Savant Syndrome

Savant syndrome is an enigmatic disorder. It is characterized by cluster of outstanding mental ability in otherwise handicapped individuals. People with savant syndrome exhibit exceptional-extraordinary abilities and demonstrate some specific talents or particular skills along with developmental disabilities. Their profound and prodigous abilities are far in excess of what are considered normal. There is a paradoxical presence of special skills and distinguished disabilities. The documented savant skills include “lightning-speed” numerical calculation, calendrical calculation, musical savants (exceptional musical abilities, especially perfect pitch), artistic skills, hyperlexics (Fast reading and understanding). Other types of talents and artistic skills involving three-dimensional drawing, map memory, poetry, painting, and sculpturing are also observed. The goal of this scientific article is to review savant syndrome, based on neurophenomenology framework and recent findings.Sindrom savant adalah gangguan yang misterius. Sindrom ini ditandai dengan adanya beberapa kemampuan mental yang menonjol pada individu dengan kelainan/cacat jasmani. Orang dengan sindrom savant menunjukkan beragam kemampuan luar-biasa serta memiliki beberapa bakat khusus atau keterampilan yang istimewa di samping gangguan perkembangan. Kemampuan yang dimilikinya melampaui kondisi normal. Ada paradoks dari kehebatan dan cacat yang dimilikinya. Beberapa keterampilan yang terdokumentasikan, misalnya: perhitungan numerik kilat, kalkulasi kalender, musik (kecuali kemampuan musikal, terutama pitch yang sempurna), keterampilan artistik, hiperleksia (kemampuan membaca dan memahami kilat). Jenis bakat dan kemampuan artistik lainnya antara lain menggambar tiga dimensi, ingatan tentang peta, puisi, lukisan, dan seni memahat. Tujuan artikel ilmiah ini adalah untuk meninjau sindrom savant berdasarkan pendekatan neurofenomenologi, dan kepustakaan serta riset terkini

Troubled Helix – Tinjauan Multiperspektif Genetika dalam Bioetika

Dalam review ini, dibahas tinjauan multiperspektif genetika dalam bioetika. Dikemukakan prinsip-prinsip etika mutakhir, seperti: reciprocity, mutuality, solidarity, citizenry, dan universality. Dibahas pula prinsip-prinsip etika dan pemeriksaan genetika, seperti: otonomi, privasi, kebaikan, nonmaleficence, keadilan. Didiskusikan pula perspektif etnokultural dalam layanan genetika, milestones guideline etika dan regulasi riset biomedis Internasional, prinsip-prinsip etika menurut Universal Declaration on Bioethics and Human Rights 2005, hak asasi manusia dan etika profesional: apresiasi translasional, perspektif utilitarianisme, perspektif deontologi, “simalakama” pemeriksaan genetika, globalisasi bioetika, etika bioinformatika, dan riset eugenik.In this review, a multiperspective review of genetics in bioethics is discussed. The latest ethical principles are mentioned, such as: reciprocity, mutuality, solidarity, citizenry, and universality. The principles of ethics and genetic inquiry, such as: autonomy, privacy, kindness, nonmaleficence, justice was also discussed. Also discussed are multiperspective, ethnocultural perspectives in genetic services, milestones of ethical guidelines and International biomedical research regulations, ethical principles according to the Universal Declaration on Bioethics and Human Rights 2005, human rights and professional ethics: translational appreciation, utilitarianism perspective, deontological perspective, the “simulacra” of genetic examination, bioethics globalization, bioinformatics ethics, and eugenic research

Sindrom Asperger

Sindrom Asperger (AS) atau sindrom profesor kecil telah dikenal lebih dari 50 tahun yang lalu. Ditandai dengan adanya gangguan interaksi sosial, minat yang berulang, terbatas atau sempit, rutinitas yang repetitif, problematika komunikasi nonverbal, keunikan motorik, keanehan berbicara dan berbahasa disertai keterlambatan penguasaan bahasa dengan kecerdasan normal. Secara klinis dibedakan dari autisme dan high-functioning autism oleh ketiadaan keterlambatan berbicara. Tinjauan ini membahas mengenai sinonim, sejarah, definisi, epidemiologi, etiologi, potret klinis, karakteristik dan ciri khas, diagnosis, penyerta, diagnosis banding, pemeriksaan penunjang, penatalaksanaan, dan pencegahan sindrom Asperger.Asperger syndrome (AS) or little professor syndrome was described since over 50 years ago. It is characterized by social interaction impairments, narrow and restrictive or repetitive interests, repetitive routines, nonverbal communication problems, motor clumsiness, speech and language peculiarities with a lack of significant delays in language acquisition and with normal intelligence. It is clinically differentiated from autism and high-functioning autism by the absence of clinically delayed speech. This review discusses about synonyms, history, definition, epidemiology, etiology, clinical portraits, characteristics and pathognomonics, diagnostics, comorbidities, differential diagnosis, additional assessments, management, and prevention of AS