Occurrence of linezolid induced thrombocytopenia and its association with the risk factors: a review article

Linezolid is the oxazolidinone group of antibiotic with wide range of activity against the gram positive bacteria including methicillin resistant staphylococcus aureus and penicillin resistant pneumococci and vancomycin resistant enterococci. Patients who are on linezolid were reported to have reversible myelosuppression especially thrombocytopenia and anaemia. Since there are less number of studies regarding the occurrence of thrombocytopenia and the risk factors associated with it, this study was undertaken to evaluate the occurrence of linezolid induced thrombocytopenia and its association with risk factors. It was a systematic review with synthesis of available literature in English language. Articles were retrieved using search terms included “linezolid”, “and”, “or”, “thrombocytopenia” from Clinical key and PubMed, published during 2000 - 2017. Out of 16 studies retrieved, only 7 studies were analysed based on inclusion and exclusion criteria; of them, 3 were found to be prospective and retrospective cohort each and only one was retrospective cross-sectional study. The occurrence of linezolid induced thrombocytopenia range from 18-50% with normal renal function and 57% of incidence associated with renal insufficiency patients. The risk factors were found to be dose of linezolid >18-27mg/kg, body weight of subjects <55kg, creatinine clearance <88.39 to 60ml/min/1.73m2 and baseline platelet count <200*103/mm3, serum albumin concentration, serum creatinine, concomitant caspofungin therapy and duration of linezolid therapy

X-ray Properties of the Weak Seyfert 1 Nucleus in NGC 4639

We obtained observations of NGC 4639 with ASCA in order to investigate its mildly active Seyfert 1 nucleus at hard X-ray energies. Koratkar et al. (1995) have previously shown that the nucleus is a pointlike source in the ROSAT soft X-ray band. We detected in the 2-10 keV band a compact central source with a luminosity of 8.3E+40 erg/s. Comparison of the ASCA data with archival data taken with the Einstein and ROSAT satellites shows that the nucleus varies on timescales of months to years. The variability could be intrinsic, or it could be caused by variable absorption. More rapid variability, on a timescale of \~10^4 s, may be present in the ASCA data. The spectrum from 0.5 to 10 keV is well described by a model consisting of a lightly absorbed (N_H = 7.3E+20 cm^-2) power law with a photon index of 1.68. We find no evidence for significant emission from a thermal plasma; if present, it can account for no more than 25% of the flux in the 0.5-2.0 keV band. The limited photon statistics of our data do not allow us to place significant limits on the presence of iron K emission. (abridged)Comment: To appear in The Astrophysical Journal. LaTex, 18 pages including embedded figures and table

Emergence of Order in Textured Patterns

A characterization of textured patterns, referred to as the disorder function \bar\delta(\beta), is used to study properties of patterns generated in the Swift-Hohenberg equation (SHE). It is shown to be an intensive, configuration-independent measure. The evolution of random initial states under the SHE exhibits two stages of relaxation. The initial phase, where local striped domains emerge from a noisy background, is quantified by a power law decay \bar\delta(\beta) \sim t^{-{1/2} \beta}. Beyond a sharp transition a slower power law decay of \bar\delta(\beta), which corresponds to the coarsening of striped domains, is observed. The transition between the phases advances as the system is driven further from the onset of patterns, and suitable scaling of time and \bar\delta(\beta) leads to the collapse of distinct curves. The decay of $\bar\delta(\beta)$ during the initial phase remains unchanged when nonvariational terms are added to the underlying equations, suggesting the possibility of observing it in experimental systems. In contrast, the rate of relaxation during domain coarsening increases with the coefficient of the nonvariational term.Comment: 9 Pages, 8 Postscript Figures, 3 gif Figure

Study of qualitative traits of germplasm of tomato (Solanum lycopersicum L.)

Forty genotypes of tomato germplasm under present investigation were characterized based on 11 qualitative traits viz., leaf colour, leaf pubescence, leaf / foliage cover, petiole pubescence, stem type, stem thickness, stem pigmentation, flower size, flower colour, fruit size, fruit shape. Tomato genotypes exhibited high variability for all qualitative traits viz., Leaf characters, stem characters, flower characters and fruit characters. Therefore, it is emphasized to lay attention on the traits viz., days to first flowering, number of fruits per plant, fruit weight in crop improvement programme of tomato in future

Correlation and path coefficient analysis in tomato (Solanum lycopersicum L.)

Forty genotypes of tomato were used to study the correlation and path coefficient analysis of thirteen yield and yield related traits during Kharif, 2017-18. Fruit yield per plant exhibited high significant positive correlations with average fruit weight, yield per hectare, beta carotene and lycopene. It also registered significant negative correlation with plant height, number of primary branches per plant, days to fruit set, number of fruits per plant, ascorbic acid and TSS. Path analysis revealed that the traits like number of fruits per plant and average fruit weight exhibited positive direct effects on fruit yield and these traits also recorded positive correlation with yield. This suggested that direct selection based on these traits will be rewarding for crop yield improvement

Incidence of Mast Cells in Oral Squamous Cell Carcinoma: A Short Study

Mast cells are regarded as complex and multifunctional cells, playing a significant role in immunopathology and a substantial role in tumor angiogenesis. Angiogenesis is a complex process that is tightly regulated by various growth factors in which mast cells act directly by releasing angiogenic factors and henceforth promoting tumor growth and metastasis. The aim of this study is to evaluate the number of mast cells in tissue sections of oral squamous cell carcinoma (OSCC) in comparison with normal mucosa. A total of 40 cases (20 OSCC and 20 normal mucosa) were stained with 1% toluidine blue and the quantitative analysis was done by using light microscope under 400x magnification. A significant increase in the mast cell count was observed in the sections of OSCC when compared to normal mucosa suggesting their contributing role in tumor growth and progression

Incidence of Mast Cells in Oral Squamous Cell Carcinoma: A Short Study

Mast cells are regarded as complex and multifunctional cells, playing a significant role in immunopathology and a substantial role in tumor angiogenesis. Angiogenesis is a complex process that is tightly regulated by various growth factors in which mast cells act directly by releasing angiogenic factors and henceforth promoting tumor growth and metastasis. The aim of this study is to evaluate the number of mast cells in tissue sections of oral squamous cell carcinoma (OSCC) in comparison with normal mucosa. A total of 40 cases (20 OSCC and 20 normal mucosa) were stained with 1% toluidine blue and the quantitative analysis was done by using light microscope under 400x magnification. A significant increase in the mast cell count was observed in the sections of OSCC when compared to normal mucosa suggesting their contributing role in tumor growth and progression

Doubling grain Fe and Zn concentration in sorghum to combat the micronutrient malnutrition in sorghum eating populations

Dietary induced micronutrient malnutrition (MNM) is one of the greatest global challenges of our times and India has largest number of malnourished people globally. Sorghum is among the major staples and a cheapest sources of micronutrients therefore, biofortification of sorghum is of high priority. From screening of more than 4000 accessions and breeding lines we identified promising donors for Fe and Zn and established the genetic control. Fe and Zn are quantitatively inherited. While grain Zn in predominantly under additive gene control, non-additive gene actions also has role in controlling grain Fe. To develop hybrids with high Fe and Zn both parents should have high Fe and Zn. We demonstrated the prediction of F1 hybrid performance based on mid-parental value for Fe and Zn. Both Fe and Zn are positively correlated (r=0.6 to 0.8) and simultaneous improvement for Fe and Zn is feasible. Using RIL population sorghum genetic map was constructed with 2,088 markers (1148 DArTs, 927 DArTSeqs and 13 SSRs) covering 1355.52 cM with an average marker interval of 0.6cM. Forty-seven QTLs (individual) and 7 QTLs (across) environments with small maineffect and 21 co-localized QTLs for Fe and Zn were identified

Clinicopathological Profile and Surgical Treatment of Abdominal Tuberculosis: A Single Centre Experience in Northwestern Tanzania.

Abdominal tuberculosis continues to be a major public health problem worldwide and poses diagnostic and therapeutic challenges to general surgeons practicing in resource-limited countries. This study was conducted to describe the clinicopathological profile and outcome of surgical treatment of abdominal tuberculosis in our setting and compare with what is described in literature. A prospective descriptive study of patients who presented with abdominal tuberculosis was conducted at Bugando Medical Centre (BMC) in northwestern Tanzania from January 2006 to February 2012. Ethical approval to conduct the study was obtained from relevant authorities. Statistical data analysis was performed using SPSS version 17.0. Out of 256 patients enrolled in the study, males outnumbered females. The median age was 28 years (range = 16-68 years). The majority of patients (77.3%) had primary abdominal tuberculosis. A total of 127 (49.6%) patients presented with intestinal obstruction, 106 (41.4%) with peritonitis, 17 (6.6%) with abdominal masses and 6 (2.3%) patients with multiple fistulae in ano. Forty-eight (18.8%) patients were HIV positive. A total of 212 (82.8%) patients underwent surgical treatment for abdominal tuberculosis. Bands /adhesions (58.5%) were the most common operative findings. Ileo-caecal region was the most common bowel involved in 122 (57.5%) patients. Release of adhesions and bands was the most frequent surgical procedure performed in 58.5% of cases. Complication and mortality rates were 29.7% and 18.8% respectively. The overall median length of hospital stay was 32 days and was significantly longer in patients with complications (p < 0.001). Advanced age (age ≥ 65 years), co-morbid illness, late presentation, HIV positivity and CD4+ count < 200 cells/μl were statistically significantly associated with mortality (p < 0.0001). The follow up of patients were generally poor as only 37.5% of patients were available for follow up at twelve months after discharge. Abdominal tuberculosis constitutes a major public health problem in our environment and presents a diagnostic challenge requiring a high index of clinical suspicion. Early diagnosis, early anti-tuberculous therapy and surgical treatment of the associated complications are essential for survival