Ulcerative colitis: let's talk about extent

Ulcerative colitis (UC) is a chronic inflammatory disease in which clinical course varies substantially between patients. The extent of the disease is usually pointed out as one of the factors responsible for this variation. With this study, we pretended to evaluate the differences in natural history and pharmacological therapy prescription between left-sided and extended UC

Predicting the critical density of topological defects in O(N) scalar field theories

O(N) symmetric $\lambda \phi^4$ field theories describe many critical phenomena in the laboratory and in the early Universe. Given N and $D\leq 3$, the dimension of space, these models exhibit topological defect classical solutions that in some cases fully determine their critical behavior. For N=2, D=3 it has been observed that the defect density is seemingly a universal quantity at T_c. We prove this conjecture and show how to predict its value based on the universal critical exponents of the field theory. Analogously, for general N and D we predict the universal critical densities of domain walls and monopoles, for which no detailed thermodynamic study exists. This procedure can also be inverted, producing an algorithm for generating typical defect networks at criticality, in contrast to the canonical procedure, which applies only in the unphysical limit of infinite temperature.Comment: 4 pages, 3 figures, uses RevTex, typos in Eq.(11) and (14) correcte

Presence of Tomistoma cf. lusitanica (Vianna i Moraes, 1945) (Reptilia: Crocodylia) in the early Burdigalian of Mallorca (Balearic Islands, Western Mediterranean). palaeoenvironmental implications

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The role of point-like topological excitations at criticality: from vortices to global monopoles

We determine the detailed thermodynamic behavior of vortices in the O(2) scalar model in 2D and of global monopoles in the O(3) model in 3D. We construct new numerical techniques, based on cluster decomposition algorithms, to analyze the point defect configurations. We find that these criteria produce results for the Kosterlitz-Thouless temperature in agreement with a topological transition between a polarizable insulator and a conductor, at which free topological charges appear in the system. For global monopoles we find no pair unbinding transition. Instead a transition to a dense state where pairs are no longer distinguishable occurs at T<Tc, without leading to long range disorder. We produce both extensive numerical evidence of this behavior as well as a semi-analytic treatment of the partition function for defects. General expectations for N=D>3 are drawn, based on the observed behavior.Comment: 14 pages, REVTEX, 13 eps figure

c-Src inhibition improves cardiovascular function but not remodeling or fibrosis in Ang II-induced hypertension

c-Src plays an important role in angiotensin II (Ang II) signaling. Whether this member of the Src family kinases is involved in the development of Ang II–induced hypertension and associated cardiovascular damage in vivo remains unknown. Here, we studied Ang II–infused (400 ng/kg/min) mice in which c-Src was partially deleted (c-Src+/−) and in wild-type (WT, c-Src+/+) mice treated with a c-Src inhibitor (CGP077675; 25 mg/kg/d). Ang II increased blood pressure and induced endothelial dysfunction in WT mice, responses that were ameliorated in c-Src+/− and CGP077675-treated mice. Vascular wall thickness and cross-sectional area were similarly increased by Ang II in WT and c-Src+/− mice. CGP077675 further increased cross-sectional area in hypertensive mice. Cardiac dysfunction (ejection fraction and fractional shortening) in Ang II–infused WT mice was normalized in c-Src+/− mice. Increased oxidative stress (plasma thiobarbituric acid–reactive substances, hydrogen peroxide, and vascular superoxide generation) in Ang II–infused WT mice was attenuated in c-Src–deficient and CGP077675-treated mice. Hyperactivation of vascular c-Src, ERK1/2 (extracellular signal–regulated kinase 1/2), and JNK (c-Jun N-terminal kinase) in hypertensive mice was normalized in CGP077675-treated and c-Src+/− mice. Vascular fibronectin was increased by Ang II in all groups and further augmented by CGP077675. Cardiac fibrosis and inflammation induced by Ang II were amplified in c-Src+/− and CGP-treated mice. Our data indicate that although c-Src downregulation attenuates development of hypertension, improves endothelial and cardiac function, reduces oxidative stress, and normalizes vascular signaling, it has little beneficial effect on fibrosis. These findings suggest a divergent role for c-Src in Ang II–dependent hypertension, where c-Src may be more important in regulating redox-sensitive cardiac and vascular function than fibrosis and remodeling

On formation of domain wall lattices

We study the formation of domain walls in a phase transition in which an S_5\times Z_2 symmetry is spontaneously broken to S_3\times S_2. In one compact spatial dimension we observe the formation of a stable domain wall lattice. In two spatial dimensions we find that the walls form a network with junctions, there being six walls to every junction. The network of domain walls evolves so that junctions annihilate anti-junctions. The final state of the evolution depends on the relative dimensions of the simulation domain. In particular we never observe the formation of a stable lattice of domain walls for the case of a square domain but we do observe a lattice if one dimension is somewhat smaller than the other. During the evolution, the total wall length in the network decays with time as t^{-0.71}, as opposed to the usual t^{-1} scaling typical of regular Z_2 networks.Comment: 7 pages, 4 figures. Minor changes, final version accepted for publication in Phys. Rev.

Detection and Quantification of Grass and Olea Airborne Pollen Allergens in Outdoor Air Samples and its Correlation with Pollen Counts

Detection and Quantification of Grass and Olea Airborne Pollen Allergens in Outdoor Air Samples and its Correlation with Pollen Counts R Ferro1*, R Ribeiro1*, MR Martins1,2, AT Caldeira1,3, E Caeiro6, CM Antunes1,5 & R Brandão2,4 and the HIALINE working group7 1Dep. of Chemistry, University of Evora, Portugal; 2Mediterranean Inst. Crop and Environment Sciences, Univ.Evora, Portugal; 3Centro Química, University of Évora, Portugal; 4Dep. Biology, University of Evora; 5Center for NeuroSciences and Cell Biology-University of Coimbra, Portugal; 6Soc.Portuguesa Alergol.Imunologia Clínica , Portugal 7 M. Thibaudon, France, M. Smith, United Kingdom, C. Galan, Spain R. Albertini, Italy, L. Grewling, Poland, G. Reese, Germany, A. Rantio-Lehtimäki, Finland, S. Jäger and U. Berger, Austria, M. Sofiev, Finland, I. Sauliene, Lithuania, L. Cecchi, Italy Presenting author: [email protected] tel: +351 266760889 Introduction: Allergic respiratory diseases broken out after an exposure to airborne pollen, as asthma and allergic rhinitis, are deeply increasing and they represent one of the major public health problems nowadays, affecting about 40% of European population. In Portugal, grass and Olea europaea pollen are certainly one of the main sources of athmospheric aeroallergens and as such, one of the main causes of respiratory allergy. For these reasons, it is useful the development of new strategies for prevention and treatment of these pathologies. The execution of aerobiological analysis including pollen calendars and/or immunoassays for the detection and quantification of allergens which could forecast the allergenic potential of the athmosphere are quite relevant since they would contribute to develop prevention measures of allergic respiratory diseases. The aim of this study was to evaluate the putative correlation between the concentration of some of the major allergens of and with their pollen counts. Methodology: On a meteorological platform at the town center of Evora (south Portugal), ambient air was sampled at 800L/min with a Chemvol high-volume cascade impactor equipped with stages PM>10µm, 10 µm>PM>2.5µm. The polyurethane impacting substrate was extracted with 0.1M NH4HCO3, pH8.1, supplemented with 0.1% BSA. The major pollen allergens from grass Phleum p 5 and olive Ole e 1 were determined with allergen specific ELISA´s. Airborne pollen of and Olea europaea simultaneously monitored with a Burkard Seven Day Recording Volumetric Spore Trap* , between the 30th of April and the 8th of July of 2009. Both samplers were placed side-by-side with air input at the same level. Results: During the pollen season of 2009, high values of grass pollen were recorded between May 2th and June 1 th. It was also observed that the air content of Phl p5 or Ole e1 aeroallergens were directly correlated with airborne pollen counts of Poaceae and Oleaceae, respectively. Conclusions: These results suggest that the directly quantification of aeroallergens may contribute, together with pollen counts of air samples, to define the allergic risk with higher precision. Acknowledgments: This study is integrated in the european project HIALINE (Executive Agency for Health and Consumers under grant agreement No 2008 11 07

Environmental risk evaluation of potential toxic elements in stream sediments – Monfortinho area (Central Portugal)

Os elementos potencialmente tóxicos (EPT) em sedimentos de corrente constituem uma importante ferramenta na avaliação do risco ambiental na influência de depósitos minerais. A região de Monfortinho está localizada na bacia hidrográfica do rio Erges, que faz fronteira com Espanha. Desde a época romana, que se conhecem evidências da exploração de ouro sedimentar nesta região do país, a qual tem vindo a desaparecer ao longo do tempo. Na avaliação da distribuição espacial de EPT selecionados – As, B, Ba, Cd, Cu, Fe, Ni, Pb, V e Zn - foram analisadas 217 amostras de sedimentos de corrente. Os sedimentos de corrente mostram uma elevada variabilidade na concentração dos EPT, podendo concluir-se que os valores mais elevados se relacionam com as mineralizações de Au na região de Monfortinho, bem como, com as de Sn-W que ocorrem nas proximidades. A maioria dos EPT apresenta um fator de contaminação moderado, embora para o Ba, Cr e B este seja elevado a muito elevado; o que se reflete num grau de contaminação moderado a elevado para a área de estudo. Na influência dos vários EPT, a maioria da área mostra um índice de resposta à toxicidade baixo, embora em 5% das amostras este seja moderado.Potentially toxic elements (PTE) of stream sediments are an important tool in environmental risk assessment associated with mineralized deposits. εonfortinho is in the watershed of the Erges river, a transboundary river with Spain. Since Roman period, there is evidence of sedimentary gold exploitation in this region, which has ceased over time. To define a spatial distribution of selected PTE - As, B, Ba, Cd, Cu, Fe, Ni, Pb, V and Zn - β17 samples of stream sediments were analysed. Stream sediments show a high PTE contents variability, suggesting that the highest values are related to the Au mineralization in εonfortinho, as well as the Sn-→ mineralization’s around the study area. Almost stream sediments show a moderate PTE contamination factor, although for Ba, Cr and B has a very high contamination; which is reflected in a moderate to high degree of contamination in the area. All the PTE contribution indicate a low toxic response index for the area, although for 5% of stream sediments indicate a moderate associated toxicity.Os autores agradecem ao δNEG (atual representante dos Serviços Geológicos de Portugal) pela cedência dos dados. Este trabalho foi desenvolvido no âmbito do ICT – Universidade do εinho (Braga).info:eu-repo/semantics/publishedVersio