4,444 research outputs found
Network sensitivity to geographical configuration
Gravitational wave astronomy will require the coordinated analysis of data
from the global network of gravitational wave observatories. Questions of how
to optimally configure the global network arise in this context. We have
elsewhere proposed a formalism which is employed here to compare different
configurations of the network, using both the coincident network analysis
method and the coherent network analysis method. We have constructed a network
model to compute a figure-of-merit based on the detection rate for a population
of standard-candle binary inspirals. We find that this measure of network
quality is very sensitive to the geographic location of component detectors
under a coincident network analysis, but comparatively insensitive under a
coherent network analysis.Comment: 7 pages, 4 figures, accepted for proceedings of the 4th Edoardo
Amaldi conference, incorporated referees' suggestions and corrected diagra
A new algorithm to diagnose atrial ectopic origin from multi lead ECG systems - insights from 3D virtual human atria and torso
Rapid atrial arrhythmias such as atrial fibrillation (AF) predispose to ventricular arrhythmias, sudden cardiac death and stroke. Identifying the origin of atrial ectopic activity from the electrocardiogram (ECG) can help to diagnose the early onset of AF in a cost-effective manner. The complex and rapid atrial electrical activity during AF makes it difficult to obtain detailed information on atrial activation using the standard 12-lead ECG alone. Compared to conventional 12-lead ECG, more detailed ECG lead configurations may provide further information about spatio-temporal dynamics of the body surface potential (BSP) during atrial excitation. We apply a recently developed 3D human atrial model to simulate electrical activity during normal sinus rhythm and ectopic pacing. The atrial model is placed into a newly developed torso model which considers the presence of the lungs, liver and spinal cord. A boundary element method is used to compute the BSP resulting from atrial excitation. Elements of the torso mesh corresponding to the locations of the placement of the electrodes in the standard 12-lead and a more detailed 64-lead ECG configuration were selected. The ectopic focal activity was simulated at various origins across all the different regions of the atria. Simulated BSP maps during normal atrial excitation (i.e. sinoatrial node excitation) were compared to those observed experimentally (obtained from the 64-lead ECG system), showing a strong agreement between the evolution in time of the simulated and experimental data in the P-wave morphology of the ECG and dipole evolution. An algorithm to obtain the location of the stimulus from a 64-lead ECG system was developed. The algorithm presented had a success rate of 93%, meaning that it correctly identified the origin of atrial focus in 75/80 simulations, and involved a general approach relevant to any multi-lead ECG system. This represents a significant improvement over previously developed algorithms
Post-operative atrial fibrillation is influenced by beta-blocker therapy but not by pre-operative atrial cellular electrophysiology
We investigated whether post-cardiac surgery (CS) new-onset atrial fibrillation (AF) is predicted by pre-CS atrial cellular electrophysiology, and whether the antiarrhythmic effect of beta-blocker therapy may involve pre-CS pharmacological remodeling. Atrial myocytes were obtained from consenting patients in sinus rhythm, just prior to CS. Action potentials and ion currents were recorded using whole-cell patch-clamp technique. Post-CS AF occurred in 53 of 212 patients (25%). Those with post-CS AF were older than those without (67 ± 2 vs 62 ± 1 years, P = 0.005). In cells from patients with post-CS AF, the action potential duration at 50% and 90% repolarization, maximum upstroke velocity, and effective refractory period (ERP) were 13 ± 4 ms, 217 ± 16 ms, 185 ± 10 V/s, and 216 ± 14 ms, respectively (n = 30 cells, 11 patients). Peak L-type Ca2+ current, transient outward and inward rectifier K+ currents, and the sustained outward current were â5.0 ± 0.5, 12.9 ± 2.4, â4.1 ± 0.4, and 9.7 ± 1.0 pA/pF, respectively (13-62 cells, 7-19 patients). None of these values were significantly different in cells from patients without post-CS AF (P > 0.05 for each, 60-279 cells, 29-86 patients), confirmed by multiple and logistic regression. In patients treated >7 days with a beta-blocker pre-CS, the incidence of post-CS AF was lower than in non-beta-blocked patients (13% vs 27%, P = 0.038). Pre-CS beta-blockade was associated with a prolonged pre-CS atrial cellular ERP (P = 0.001), by a similar degree (âŒ20%) in those with and without post-CS AF. Conclusion: Pre-CS human atrial cellular electrophysiology does not predict post-CS AF. Chronic beta-blocker therapy is associated with a reduced incidence of post-CS AF, unrelated to a pre-CS ERP-prolonging effect of this treatment
Giant Molecular Clouds are More Concentrated to Spiral Arms than Smaller Clouds
From our catalog of Milky Way molecular clouds, created using a temperature
thresholding algorithm on the Bell Laboratories 13CO Survey, we have extracted
two subsets:(1) Giant Molecular Clouds (GMCs), clouds that are definitely
larger than 10^5 solar masses, even if they are at their `near distance', and
(2) clouds that are definitely smaller than 10^5 solar masses, even if they are
at their `far distance'. The positions and velocities of these clouds are
compared to the loci of spiral arms in (l, v) space. The velocity separation of
each cloud from the nearest spiral arm is introduced as a `concentration
statistic'. Almost all of the GMCs are found near spiral arms. The density of
smaller clouds is enhanced near spiral arms, but some clouds (~10%) are
unassociated with any spiral arm. The median velocity separation between a GMC
and the nearest spiral arm is 3.4+-0.6 km/s, whereas the median separation
between smaller clouds and the nearest spiral arm is 5.5+-0.2 km/s.Comment: 11 pages, 3 figure
The ACIGA Data Analysis programme
The Data Analysis programme of the Australian Consortium for Interferometric
Gravitational Astronomy (ACIGA) was set up in 1998 by the first author to
complement the then existing ACIGA programmes working on suspension systems,
lasers and optics, and detector configurations. The ACIGA Data Analysis
programme continues to contribute significantly in the field; we present an
overview of our activities.Comment: 10 pages, 0 figures, accepted, Classical and Quantum Gravity,
(Proceedings of the 5th Edoardo Amaldi Conference on Gravitational Waves,
Tirrenia, Pisa, Italy, 6-11 July 2003
Singular value decomposition applied to compact binary coalescence gravitational-wave signals
We investigate the application of the singular value decomposition to
compact-binary, gravitational-wave data-analysis. We find that the truncated
singular value decomposition reduces the number of filters required to analyze
a given region of parameter space of compact binary coalescence waveforms by an
order of magnitude with high reconstruction accuracy. We also compute an
analytic expression for the expected signal-loss due to the singular value
decomposition truncation.Comment: 4 figures, 6 page
A systematic review of cost-effectiveness analyses of complex wound interventions reveals optimal treatments for specific wound types.
BackgroundComplex wounds present a substantial economic burden on healthcare systems, costing billions of dollars annually in North America alone. The prevalence of complex wounds is a significant patient and societal healthcare concern and cost-effective wound care management remains unclear. This article summarizes the cost-effectiveness of interventions for complex wound care through a systematic review of the evidence base.MethodsWe searched multiple databases (MEDLINE, EMBASE, Cochrane Library) for cost-effectiveness studies that examined adults treated for complex wounds. Two reviewers independently screened the literature, abstracted data from full-text articles, and assessed methodological quality using the Drummond 10-item methodological quality tool. Incremental cost-effectiveness ratios were reported, or, if not reported, calculated and converted to United States Dollars for the year 2013.ResultsOverall, 59 cost-effectiveness analyses were included; 71% (42 out of 59) of the included studies scored 8 or more points on the Drummond 10-item checklist tool. Based on these, 22 interventions were found to be more effective and less costly (i.e., dominant) compared to the study comparators: 9 for diabetic ulcers, 8 for venous ulcers, 3 for pressure ulcers, 1 for mixed venous and venous/arterial ulcers, and 1 for mixed complex wound types.ConclusionsOur results can be used by decision-makers in maximizing the deployment of clinically effective and resource efficient wound care interventions. Our analysis also highlights specific treatments that are not cost-effective, thereby indicating areas of resource savings. Please see related article: http://dx.doi.org/10.1186/s12916-015-0288-5
Spectral Line Removal in the LIGO Data Analysis System (LDAS)
High power in narrow frequency bands, spectral lines, are a feature of an
interferometric gravitational wave detector's output. Some lines are coherent
between interferometers, in particular, the 2 km and 4 km LIGO Hanford
instruments. This is of concern to data analysis techniques, such as the
stochastic background search, that use correlations between instruments to
detect gravitational radiation. Several techniques of `line removal' have been
proposed. Where a line is attributable to a measurable environmental
disturbance, a simple linear model may be fitted to predict, and subsequently
subtract away, that line. This technique has been implemented (as the command
oelslr) in the LIGO Data Analysis System (LDAS). We demonstrate its application
to LIGO S1 data.Comment: 11 pages, 5 figures, to be published in CQG GWDAW02 proceeding
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