Tabvla Asiae VII

Publication: [Agrippinensium Colonia?] : [Excudebat Petrus Keschedt?], [1597?] Physical Description: 1 map ; 14 x 18 cm, on sheet 17 x 23 cm Language: Latin Cartographic Mathematical Data: Scale not given, (E 49°35ʹ--E 82°05ʹ/N 43°33ʹ--N 26°01ʹ). Notes: Ptolemaic map covering central Asia, including the Persian Gulf, Caspian Sea, Iran, Afghanistan, Pakistan, and India. Relief shown pictorially. Uncolored. Copper-plate map. Verso is page 22 of an unidentified text in Latin, with heading: Asiae Tabvla VI. Taken from an early edition of Giovanni Antonio Magini\u27s Ptolemy\u27s Geographia, tentatively identified as: Ptolemy. Geographiae vniuersae tum veteris, tum nouae abolutissimum opus, duobus voluminibus districtum. Agrippinensium Colonia : Excudebat Petrus Keschedt, 1597

Synthesis and antiproliferative activities of quebecol and its analogs

Simple and efficient synthesis of quebecol and a number of its analogs was accomplished in five steps. The synthesized compounds were evaluated for antiproliferative activities against human cervix adenocarcinoma (HeLa), human ovarian carcinoma (SK-OV-3), human colon carcinoma (HT-29), and human breast adenocarcinoma (MCF-7) cancer cell lines. Among all the compounds, 7c, 7d, 7f, and 8f exhibited antiproliferative activities against four tested cell lines with inhibition over 80% at 75 μM after 72 h, whereas, compound 7b and 7g were more selective towards MCF-7 cell line. The IC50 values for compounds 7c, 7d, and 7f were 85.1 μM, 78.7 μM, and 80.6 μM against MCF-7 cell line, respectively, showing slightly higher antiproliferative activtiy than the synthesized and isolated quebecol with an IC50 value of 104.2 μM against MCF-7. [Refer to PDF for graphical abstract

Cue-Signal-Response Analysis in 3D Chondrocyte Scaffolds with Anabolic Stimuli

Articular cartilage is an avascular connectivetissue responsible for bearing loads. Cell signaling plays acentral role in cartilage homeostasis and tissue engineering bydirecting chondrocytes to synthesize/degrade the extracellularmatrix or promote inflammatory responses. The aim ofthis paper was to investigate anabolic, catabolic and inflammatorypathways of well-known and underreported anabolicstimuli in 3D chondrocyte cultures and connect them todiverse cartilage responses including matrix regeneration andcell communication. A cue-signal-response experiment wasperformed in chondrocytes embedded in alginate scaffoldssubjected to a 9-day treatment with 7 anabolic cues. At thesignaling level diverse pathways were measured whereas atthe response level glycosaminoglycan (GAG) synthesis andcytokine releases were monitored. A significant increase ofGAG was observed for each stimulus and well knownanabolic phosphoproteins were activated. In addition,WNK1, an underreported protein of chondrocyte signaling,was uncovered. At the extracellular level, inflammatory andregulating cytokines were measured and DEFB1 andCXCL10 were identified as novel contributors to chondrocyteresponses, both closely linked to TLR signaling andinflammation. Finally, two new pro-growth factors with aninflammatory potential, Cadherin-11 and MGP wereobserved. Interestingly, well-known anabolic stimuli yieldedinflammatory responses which pinpoints to the pleiotropicroles of individual stimul