MOESM8 of Generation of donor-specific Tr1 cells to be used after kidney transplantation and definition of the timing of their in vivo infusion in the presence of immunosuppression

Additional file 8. Tr1 cell sorting gating strategy

Demographic and metabolic characteristics of kidney transplant individuals.

<p>Results are expressed as median (25^th, 75^th percentile).</p

Two dimensional Correlated Spectroscopy (2D COSY) results of the kidney allograft.

<p>(A) Table of 2D COSYcrosspeak volumes shows significantly lower threonine, taurine, creatine and choline content in T3 individuals with low glomerular filtration rate and severe allograft dysfunction when compared to T1 individuals with more conserved graft function. “-”indicates a p value greater than 0.05. (B) Representative 2D COSY spectra show higher content of lipid-derived metabolites and reduced levels of threonine, taurine, creatine and choline in T3 individuals carrying a failing allograft. B1 shows a topological map of crosspeaks and B2 shows the 3D reconstruction. (C) Representative 2D COSY of T1 allograft patients with more conserved graft function with two-dimensional (C1) and three-dimensional (C2) reconstruction of the 2D COSY data. Data are expressed as median (25^th, 75^th percentile). <b>Abbreviations.</b> Arbitrary Units (AU).</p