Timeline of the experimental setup for rTMS and [¹¹C]FLB 457 PET imaging.

<p>Timeline of the experimental setup for rTMS and [¹¹C]FLB 457 PET imaging.</p

Sagittal and transverse sections of the statistical parametric map of the changes in [¹¹C]FLB 457 BP after left DLPFC stimulation overlaid upon the standard MRI.

<p>Sagittal and transverse sections of the statistical parametric map of the changes in [¹¹C]FLB 457 BP after left DLPFC stimulation overlaid upon the standard MRI.</p

Prefrontal regions with reduction in [¹¹C]FLB 457 BP following left DLPFC stimulation.

<p>L: left, ACC: anterior cingulated cortex, OFC: orbitofrontal cortex, BA: Brodmann's area *Talairach coordinate (mm), SVC: small volume correction.</p

Individual mean BPs extracted from 10 mm radius VOI.

<p>Upper, middle and lower figures show the individual [¹¹C]FLB 457 BP changes the subgenual ACC (x = −10, y = 28, z = −18), pregenual ACC (x = −14, y = 40, z = −10) and medial orbitofrontal cortex (x = −6, y = 30, z = −20) under control and active rTMS conditions, respectively.</p

Contrast analysis for each stimulation conditions: changes in [11C]FLB 457 BP of the stimulated hemisphere were tested against [11C]FLB 457 BP of the ipsilateral (non-stimulated) hemisphere of the other session (control).

<p>Red mark indicate stimulation site.</p

Mean [¹¹C]FLB 457 BP changes in prefrontal regions following left and right DLPFC.

<p>ACC: anterior cingulated cortex, OFC: orbitofrontal cortex, DLPFC: dorsolateral prefrontal cortex, Number in brackets indicates S.D.</p><p>*Bonferroni correction.</p

Matching after negative feedback minus matching after positive feedback (partial).

<p>Abbreviations, same as <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0006154#pone-0006154-t002" target="_blank">Table 2</a>. We only report here the left premotor cluster of activation.</p

subjects information.

<p>Abbreviations: Subj.: subject, F: female, M: male, lat.: laterality, R: right-handed, A: ambidextrous, med.: medication, DA: dopamine.</p

Receiving positive feedback minus control feedback.

<p>Abbreviations, same as <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0006154#pone-0006154-t002" target="_blank">Table 2</a>.</p

Receiving negative feedback minus control feedback.

<p>Abbreviations: L, Left; R, right; DL, dorsolateral; VL, ventrolateral; CC, cingulate cortex; PMC, premotor cortex; PPC, posterior parietal cortex; TC, temporal cortex; pSMA, presupplementay motor area. When no asterisk is indicated, p<0.05 corrected; *p<0.001 uncorrected. Cluster sizes are reported in mm3. sc indicates that the peak is part of the same cluster as the peak listed immediately above in the table. The numbers in parentheses refer to architectonic areas.</p