Populations analyzed.

<p>Geographical distribution of populations analyzed (in bold) and those used for comparison purposes. Pie charts show haplogroup frequencies. Red lines indicate genetic barrier intensity and green lines the Monmonier geometric traces used to construct the barriers.</p

Theta estimators of eight indigenous populations from Mesoamerica and Aridoamerica.

<p>Theta estimators of eight indigenous populations from Mesoamerica and Aridoamerica.</p

Multidimensional scaling based on the F_ST distances of eight indigenous populations from Mesoamerica and Aridoamerica (Stress = 0.097).

<p>Multidimensional scaling based on the F_ST distances of eight indigenous populations from Mesoamerica and Aridoamerica (Stress = 0.097).</p

AMOVAS based on different classification criteria.

*<p>Significance level 0.05.</p

Sequence diversity indices for mtDNA lineages in the control region (16024-576) in eight indigenous populations.

*<p>level of significance of 0.05.</p><p>N, sample size; K, number of different sequences; S, number of polymorphic sites; Ĥ, sequence diversity; π, nucleotide diversity; θ, mean number of pairwise differences between sequences; D, Tajima test of selective neutrality (sd represents the standard deviation).</p

Additional file 1: of Intra-tumor heterogeneity in TP53 null High Grade Serous Ovarian Carcinoma progression

Supplementary Materials: Whole-exome sequencing: bioinformatics analysis. (PDF 39 kb

Additional file 2: Figure S1. of Intra-tumor heterogeneity in TP53 null High Grade Serous Ovarian Carcinoma progression

Fluorescence in situ hybridisation of PML gene in primary tumor and recurrence samples shows genomic intra-tumoral heterogeneity. Representative FISH images of PML (red) and RARA (green, used as control) genes in primary tumor (P1-P6) and recurrence (IR1-IR2 and ER1-ER4) samples. Magnification = 40X. (PDF 115 kb

Time distribution (bottom) of the maximum (green points) and minimum IGR values (red points) by Mesoamerican periods (top) for populations clustered in cultural areas.

<p>The vertical red stripe indicates periods before 8,000 ybp.</p

Skyline plot for the 28 populations grouped in the five cultural regions.

<p>North, West, Central, Oaxaca and Maya.</p

Geographical and cultural information from the 28 Native American populations included in this study.

<p>Geographical and cultural information from the 28 Native American populations included in this study.</p