Description and odds ratios of having CVD^* in any field of the death certificate stratified by reported HIV status^**

*<p>CVD: ICD10 I00-I99, except cardiac arrest (I46)</p>**<p>Adjusted for state of residency</p

CVD and DM in HIV-infected/AIDS patients.

<p>Odds ratios and 95% confidence intervals comparing the chance of having the disease listed on the death certificate over time, compared with 1999. A–CVD; B–DM. Slopes for trends are significantly different between groups for CVD (p-value<0.001) and DM (p-value<0.001).</p

Description and odds ratios of having DM^* in any field of the death certificate stratified by reported HIV status^**

*<p>DM: ICD10 E10-E14, except cardiac arrest (I46)</p>**<p>Adjusted for state of residency</p

Death Rates and non-HIV-related causes of death.

<p>A–Death rates per 100 000 inhabitants of individuals that had HIV/AIDS listed on the death certificate, 1999–2004 (p-value for trend = 0.67, solid circles) and AIDS mortality as an underlying disease from 1996 to 2004 (open circles). B–Odds ratios and 95% confidence intervals of non-HIV-related causes of death listed on the death certificate in individuals who had and who did not have HIV listed on the death certificate. Slopes of trends are significantly different between the two groups (p-value<0.001)</p

Description and odds ratios of having a non-HIV related condition^* in any field of the death certificate stratified by reported HIV status^**

*<p>non-HIV-related neoplasms (C00-C80, except C46–Kaposi's sarcoma), DM (E10-E14), CVD (I00-I99), except cardiac arrest (I46), digestive diseases (K00-K93), genital-urinary diseases, (N00-N99) and external causes (S00-Y98)</p>**<p>Adjusted for state of residency</p

Observed (unweighted, black) and weighted (IPCW-weighted, gray) annual CD4+ cell counts (median and interquartile range) since start of ART.

<p>Dashed lines represent important CD4+ cell count thresholds of 200, 350, and 500 cells/μL.</p

Observed (unweighted, dots) and weighted (IPCW-weighted, lines) annual median CD4+ cell counts since start of ART stratified by pre-treatment CD4+ cell count and nadir CD4+ cell count.

<p>Dashed lines represent important CD4+ cell count thresholds of 200, 350, and 500 cells/μL.</p

Observed (unweighted, dots) and weighted (IPCW-weighted, lines) annual median CD4+ cell counts since start of ART stratified by initial ART regimen and pre-treatment HIV RNA viral load.

<p>Dashed lines represent important CD4+ cell count thresholds of 200, 350, and 500 cells/μL.</p

Unstratified and stratified observed and weighted median (interquartile range) CD4+ cell counts for years 1, 4, 7 and 10 after start of antiretroviral therapy and the percentage of patients with weighted CD4+ cell count >500/μL at year 10.

<p>HIV: human immunodeficiency virus, ART: antiretroviral therapy, ADI: AIDS defining illness.</p>a<p>Age at the start of ART.</p>b<p>Reported mode of HIV risk exposure was categorized injection drug users (IDU) and not IDU.</p>c<p>Pre-treatment CD4+ cell count and HIV RNA were defined as the value closest to the date of start of ART up to 6 months prior.</p>d<p>Initial ART regimen was classified as NNRTI-based or PI-based. Integrase inhibitor-based regimens were too few (N = 75) to draw consistent conclusions and were thus excluded.</p>e<p>ADI at the start of ART was defined as the presence of any CDC 1993 condition at six months prior to up to one month after start of ART.</p>f<p>Hepatitis B/C co-infection was defined as having chronic infection at the start of ART.</p

Observed (unweighted, dots) and weighted (IPCW-weighted, lines) annual median CD4+ cell counts since start of ART stratified by cohort, age at start of ART, gender and race.

<p>Dashed lines represent important CD4+ cell count thresholds of 200, 350, and 500 cells/μL.</p