The most frequent (%) <i>HLA</i> extended haplotypes in Arabs.

<p>The most frequent (%) <i>HLA</i> extended haplotypes in Arabs.</p

The closest populations to Arabs using standard genetic distances (SGD) based on <i>HLA-DRB1*</i> alleles.

<p>The closest populations to Arabs using standard genetic distances (SGD) based on <i>HLA-DRB1*</i> alleles.</p

Most frequent <i>HLA-DRB1*</i> and–<i>DQB1*</i> alleles in Arab populations.

<p>Most frequent <i>HLA-DRB1*</i> and–<i>DQB1*</i> alleles in Arab populations.</p

Correspondence analysis (bi-dimensional representation), based on the standard genetic distances, showing a global view of the relationship among Arabs and other populations according to generic <i>HLA*-A</i> and–<i>B*</i> allele frequencies data.

<p>Populations data were taken from references detailed in Tables <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0192269#pone.0192269.t001" target="_blank">1</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0192269#pone.0192269.t002" target="_blank">2</a>.</p

Flow diagram of the study selection process.

<p>Flow diagram of the study selection process.</p

Correspondence analysis (bi-dimensional representation), based on the standard genetic distances, showing the relationship between different Arab populations according to generic <i>HLA-DRB1*</i> allele frequencies data.

<p>Populations data were taken from references detailed in Tables <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0192269#pone.0192269.t001" target="_blank">1</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0192269#pone.0192269.t002" target="_blank">2</a>.</p

Correspondence analysis (bi-dimensional representation), based on the standard genetic distances, showing the relationship between Arabs and other populations according to high resolution <i>HLA-DRB1*</i> allele frequencies data.

<p>Only individuals with defined <i>DRB1*</i> subtypes are considered. Populations data were taken from references detailed in Tables <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0192269#pone.0192269.t001" target="_blank">1</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0192269#pone.0192269.t002" target="_blank">2</a>.</p

Most frequent <i>HLA-A*</i> and–<i>B*</i> alleles in Arab populations.

<p>Most frequent <i>HLA-A*</i> and–<i>B*</i> alleles in Arab populations.</p

Most frequent (%) <i>HLA</i> Class I (<i>A-B</i>) two-locus haplotypes with significant linkage disequilibrium (P<0.05) in Arabs.

<p>Most frequent (%) <i>HLA</i> Class I (<i>A-B</i>) two-locus haplotypes with significant linkage disequilibrium (P<0.05) in Arabs.</p

List of Arab populations used in the present work.

<p>List of Arab populations used in the present work.</p