Model of the life cycle of the information security system

When building an information security system, one of the key problems is the creation of regulatory documents. Regulators in the field of information security determine the list of necessary documentation mainly in relation to protection mechanisms (authentication, anti-virus protection, etc.) and practically do not take into account the stages of the life cycle of information security tools and personnel of the organization. The article proposes an approach to formalization of the list of information security management processes that need regulation. This approach allows the formation of information security policy to take into account the processes of personnel management and the complex of software and hardware information security, which is necessary to ensure a high level of security of critical information infrastructure

Building a model of infringer

By a model of infringer one means a set of assumptions about the specific (restricted) tools of the infringer, which the latter can use to conduct attacks. The infringer model is an important part of the organization's information security. One should realize that ignoring the model, or building it without due care, can seriously affect the security of confidential information and lead to its loss. The infringer model is informal, which implies the absence of strict and unambiguous methodology for developing such a model. There exist many academic and technical publications proposing various methods of classifying violators.  Meanwhile, many information security practitioners are forced to create their own normative and methodological documents, because existing models do not necessarily capture all the aspects of the organization's work. Despite the fact that many models have a high level of correlation between classification characteristics, it has not been possible to work out a unified model so far. We attempt to develop our own methodology for building the infringer model. We have started this project by outlining the roadmap: (1) study the existing methods of constructing the infringer model; (2) identify shortcomings of existing methods; (3) develop a model of the infringer and a methodology for listing the most likely violators, with taking into account the identified shortcomings. In the process of implementation of the plan, we have analyzed several existing models of infringer and revealed their shortcomings and inherent difficulties. In the developed model, causal relationships between the elements of the model and the chains of the alleged consequences have been constructed, and possible types of alleged violators have been described and ranked. As a result, our model allows one to create a more deep description of the infringer

Simultaneous Probing of Metabolism and Oxygenation of Tumors In Vivo Using FLIM of NAD(P)H and PLIM of a New Polymeric Ir(III) Oxygen Sensor

Tumor cells are well adapted to grow in conditions of variable oxygen supply and hypoxia by switching between different metabolic pathways. However, the regulatory effect of oxygen on metabolism and its contribution to the metabolic heterogeneity of tumors have not been fully explored. In this study, we develop a methodology for the simultaneous analysis of cellular metabolic status, using the fluorescence lifetime imaging microscopy (FLIM) of metabolic cofactor NAD(P)H, and oxygen level, using the phosphorescence lifetime imaging (PLIM) of a new polymeric Ir(III)-based sensor (PIr3) in tumors in vivo. The sensor, derived from a polynorbornene and cyclometalated iridium(III) complex, exhibits the oxygen-dependent quenching of phosphorescence with a 40% longer lifetime in degassed compared to aerated solutions. In vitro, hypoxia resulted in a correlative increase in PIr3 phosphorescence lifetime and free (glycolytic) NAD(P)H fraction in cells. In vivo, mouse tumors demonstrated a high degree of cellular-level heterogeneity of both metabolic and oxygen states, and a lower dependence of metabolism on oxygen than cells in vitro. The small tumors were hypoxic, while the advanced tumors contained areas of normoxia and hypoxia, which was consistent with the pimonidazole assay and angiographic imaging. Dual FLIM/PLIM metabolic/oxygen imaging will be valuable in preclinical investigations into the effects of hypoxia on metabolic aspects of tumor progression and treatment response

Multifunctional Elastic Nanocomposites with Extremely Low Concentrations of Single-Walled Carbon Nanotubes

Funding Information: This work was supported by Russian Foundation for Basic Research Grant No. 18-29-06071. We thank the Council on grants of the President of the Russian Federation grant number HIII-1330.2022.1.3. F.F. and D.K. thank Russian Science Foundation, Grant No. 21-73-10288 for support of impedance spectroscopy studies. Publisher Copyright: © 2022 American Chemical Society. All rights reserved.Stretchable and flexible electronics has attracted broad attention over the last years. Nanocomposites based on elastomers and carbon nanotubes are a promising material for soft electronic applications. Despite the fact that single-walled carbon nanotube (SWCNT) based nanocomposites often demonstrate superior properties, the vast majority of the studies were devoted to those based on multiwalled carbon nanotubes (MWCNTs) mainly because of their higher availability and easier processing procedures. Moreover, high weight concentrations of MWCNTs are often required for high performance of the nanocomposites in electronic applications. Inspired by the recent drop in the SWCNT price, we have focused on fabrication of elastic nanocomposites with very low concentrations of SWCNTs to reduce the cost of nanocomposites further. In this work, we use a fast method of coagulation (antisolvent) precipitation to fabricate elastic composites based on thermoplastic polyurethane (TPU) and SWCNTs with a homogeneous distributionof SWCNTs in bulk TPU. Applicability of the approach is confirmed by extra low percolation threshold of 0.006 wt % and, as a consequence, by the state-of-the-art performance of fabricated elastic nanocomposites at very low SWCNT concentrations for strain sensing (gauge factor of 82 at 0.05 wt %) and EMI shielding (efficiency of 30 dB mm-1at 0.01 wt %).Peer reviewe