812 research outputs found
Phase transition and spin-wave dispersion in quantum Hall bilayers at filling factor nu=1
We present an effective Hamiltonian for a bilayer quantum Hall system at
filling factor neglecting charge fluctuations. Our model is formulated
in terms of spin and pseudospin operators and is an exact representation of the
system within the above approximation. We analyze its low-lying excitations in
terms of spin-wave theory. Moreover we add to previous first-principle
exact-diagonalization studies concentrating on the quantum phase transition
seen in this system.Comment: Four pages, proceedings for EP2DS-14, Prague 200
Diagnostic algorithm of hyperglycemia in children
Universitatea de Medicină şi Farmacie ”Grigore T.Popa”,Iaşi, România,
Spitalul clinic de urgentă pentru copii “Sf.Maria”, Iaşi, RomâniaDefi nim hiperglicemia prin creşterea glicemiei a jeun peste 110 mg/dl sau printr-o glicemie oricand in cursul zilei
peste 140 mg/dl. În practica pediatrică, aceste valori pot fi cauzate de anumite medicamente, de stres sau pun problema
apariţiei diabetului zaharat. Dintre medicamentele care pot determina hiperglicemie menţionăm steroizii, tiazidele, hormonul
de creştere şi unele antipsihotice. Acestea din urmă au fost asociate cu o incidenţă crescută a diabetului de tip 2
si cu înrăutăţirea controlului metabolic în diabetul de tip 1.
Hiperglicemia de stres poate avea cauze minore, spre exemplu o infecţie de tract respirator superior, sau cauze severe,
chirurgicale. Hiperglicemia din infecţiile minore poate anunţa apariţia unui diabet de tip 1 sau diabet MODY şi
trebuie investigată ulterior.
Dacă valorile glicemiei sunt peste 126 mg/dl a jeun şi peste 200 mg/dl în cursul zilei, se stabileşte diagnosticul de
diabet zaharat. În peste 90% din cazuri, în copilărie şi adolescenţă se diagnostichează diabetul de tip 1, pe baza simptomelor
tipice si prin confi rmarea patogeniei autoimune, respectiv a markerilor de autoimunitate. Există şi posibilitatea unui diabet secundar asociat anumitor afectiuni, cum ar fi fi broza chistică, talasemia, feocromocitomul sau afecţiuni
genetice.
Când valorile glicemiei a jeun sunt între 100-125 mg/dl, pentru a diferenţia diabetul zaharat de tip 2 de un diabet
monogenic sau de un prediabet, se recomandă efectuarea testului oral de toleranţă la glucoză asociat cu determinarea
hemoglobinei glicozilate A1c, a anticorpilor anticelule insulare ( ICA ), a anticorpilor antiinsulinici şi a peptidului C.
În prezent, se remarcă o crestere a incidenţei diabetului zaharat de tip 2 la populatia pediatrică, şi anume la pacientii
cu obezitate şi istoric familial pozitiv de obezitate şi/sau diabet de tip 2, cu valori normale sau crescute ale peptidului
C şi fără autoanticorpi prezenţi. Diabetul de tip MODY apare la 2-3,5 % din cazurile de diabet zaharat, copiii având un
fenotip extrem de variabil, nu prezinta autoanticorpi, iar transmiterea autosomal dominanta este demonstrata de istoricul
familial de diabet la 2-3 generaţii.
În concluzie, hiperglicemia la copil pune probleme de diagostic diferenţial între debutul diabetului zaharat, un diabet
secundar, o hiperglicemie indusa medicamentos sau o hiperglicemie de stres.Hyperglycemia is defined as an increase of the fasting blood glucose level above 110 mg/dl or by random blood glucose
level above 140 mg/dl. In pediatric practice, these values may be caused by certain medications, by stress or they
may be an indication of diabetes mellitus. Here are some of the medications that may cause hyperglycemia: steroids,
thiazides, growth hormone, and some antipsychotics. The latter was associated with an increased incidence of type 2
diabetes and with poor metabolic control in type 1 diabetes.
Hyperglycemia caused by stress may have minor causes, for instance, an upper respiratory tract infection, or severe
surgical causes. Hyperglycemia caused by minor infections may be the precursor of type 1 diabetes or of MODY diabetes
and it should be further and more thoroughly analyzed.
When the fasting blood glucose levels exceed 126 mg/dl and when the blood glucose levels are over 200 mg/dl at
any time during the day, the diabetes mellitus diagnosis is set. Type 1 diabetes is diagnosed during childhood and adolescence
in over 90% of the cases, based on specific symptoms and when confirmed by autoimmune pathogenicity, i.e.
autoimmunity markers. There is also the possibility of secondary diabetes associated with certain conditions such as
cystic fibrosis, thalassemia, pheochromocytoma, or genetic disorders.
When fasting blood glucose levels are between 100-125 mg/dl, in order to distinguish type 2 diabetes from monogenic
diabetes or from prediabetes, an oral glucose tolerance test is recommended together with the determination of
glycosylated hemoglobin A1c, anti-islet cells (ICA), anti-insulin antibodies, and peptide C.
Nowadays, there is an increase in the incidence of type 2 diabetes in the pediatric population, namely in patients
with obesity and family history of obesity and/or type 2 diabetes, with normal or elevated C-peptide levels and no
autoantibodies present. MODY diabetes occurs in 2-3.5% of the cases of diabetes, as children have a very variable
phenotype, do not show autoantibodies, and dominant autosomal transmission is demonstrated by family history of
diabetes in 2-3 generations.
To conclude, hyperglycemia in children poses a differential diagnosis problem, as it is difficult to distinguish
between the onset of diabetes mellitus, secondary diabetes, medication-induced hyperglycemia, or stress-caused hyperglycemia
METABOLIC EMERGENCIES – PART II
Metabolic disorders can manifest especially in the neonatal and infant period by: hypoglycemia, heart failure,
primary hyperlactacidemia, liver failure, untreatable convulsions, neurologic damage. The authors present the
main manifestations of metabolic emergencies and their emergency treatment
URGENŢE METABOLICE – PARTEA A II-A
Afecţiunile metabolice se pot manifesta în special în perioada de nou-născut şi sugar prin: hipoglicemie, insufi cienţă cardiacă, hiperlactacidemie primară, insufi cienţă hepatică, convulsii netratabile, deteriorare neuro logică. Autorii prezintǎ principalele manifestǎri ale urgenţelor metabolice şi tratamentul de urgenţǎ
THEORY OF MIND - NOT EMOTION RECOGNITION - MEDIATES THE RELATIONSHIP BETWEEN EXECUTIVE FUNCTIONS AND SOCIAL FUNCTIONING IN PATIENTS WITH SCHIZOPHRENIA
Background: Dysfunction of social-cognitive abilities is one of the hallmark features of schizophrenia and is associated with neurocognition and social functioning. The Green and Nuechterlein model proposed that social cognition mediates the relationship between neurocognition and functional outcome. We tested this hypothesis in schizophrenia patients in the everyday clinical setting.
Subjects and methods: Social cognition, executive function and social functioning were assessed in a group of 43 patients with schizophrenia or schizoaffective disorder using a range of measures.
Results: Theory of mind was associated with executive functions and social functioning. Results of our mediation analysis suggested that the relationship between executive functions and social functioning was mediated by theory of mind. No relationships between emotion recognition and the domains of social functioning were found.
Conclusions: In line with prior research, zero-order associations were found between theory of mind and social functioning. Theory of mind was a mediator of the relationships between neurocognition and social functioning. Our results suggest that theory of mind should be a potential target of interventions to improve social functioning
Role of environmental chemicals in the development of obesity
Universitatea de Medicină şi Farmacie ”Grigore T. Popa”, Spitalul clinic de urgență pentru copii “Sf. Maria”, Iaşi, RomâniaNumeroşi factori pot avea un rol în dezvoltarea obezităţii – principala problemă de sănătate publică a secolului 21.
Ipoteza mediului obezogen sugerează că expunerea prenatală şi precoce la diferite substanţe, cum ar fi chimicale, ce
determină disrupţie endocrină pot predispune la creşterea masei grase şi exces ponderal. Lista chimicalelor studiate ca
posibili obezogeni continuă să crească şi include dietilstilbestrolul (DES), bisfenolul A (BPA), ftalaţii, organotinele,
eterii difenil-polibrominaţi (PBDEs), chimicalele polifluoroalkil (PFCs), organoclorinele (OC) pesticidele şi bifenil-policlorinatele
(PCBs). Diverse mecanisme explică rolul chimicalelor obezogene, majoritatea având efecte disruptive asupra
homeostaziei balanţei energetice, metabolismului glucozei şi lipidelor şi controlului adipogenezei. Aceste chimicale
afectează mecanismele epigenetice, structurale şi funcţionale care controlează homeostazia energetică, metabolismul
lipidic, reglarea apetitului şi adipogeneza. Expunerea la aceste chimicale are efecte diferite: în cursul perioadei fetale şi
copilăriei efectele pot fi ireversibile şi pot persista in perioada de adult, iar expunerea la doze mici în cursul perioadelor
critice ale diferenţierii pot schimba programarea dezvoltării şi pot cauza obezitate. Fumatul matern prenatal este asociat
cu apariţia în creştere a supraponderalităţii la copil şi adolescent. Unele consecinţe asupra sănătăţii pot deveni aparente
nu numai în copilărie, ci şi în perioada de adult. Alte chimicale au impact asupra retardului de creştere intrauterină,
greutăţii mici la naştere şi prematurităţii, fi ind documentate ca factori predispozanţi ai obezităţii.
Concluzie. Obezitatea epidemică ar putea fi considerată o boală complexă multifactorială. Efectul potenţial al chimicalelor
asupra dezvoltării obezităţii este mare şi sunt necesare mai multe studii asupra expunerii chimice în timpul
dezvoltării pre- şi perinatale şi apariţiei obezităţii mai târziu.Numerous factors may have a role in the development of obesity - the principal public health disease of the 21st century.
The environmental obesogen hypothesis suggests that prenatal or early-life exposure to certain substances as endocrine-
disrupting chemicals may predispose individuals to increased fat mass and excess weight. The list of chemicals
studied as possible obesogens continues to grow and includes diethylstilbestrol (DES), bisphenol A (BPA), phthalates,
organotins, polybrominated diphenyl ethers (PBDEs), polyfluoroalkyl chemicals (PFCs), organochlorine (OC) pesticides, and polychlorinated biphenyls (PCBs). Diverse mechanisms explained the role of obesogen chemicals, the majority
having disruptive effects on the homeostasis of energy balance, glucose and lipid metabolism, and control of adipogenesis.
These chemicals disrupt some epigenetic, structural, and functional mechanisms, which control energy homeostasis,
lipid metabolism, appetite regulation, and adipogenesis Exposure to these chemicals has different effects: during fetal
and infancy periods may be irreversible and long-lasting for adulthood and exposure to low doses during critical times
of differentiation can change the developmental programming and may result in obesity. Prenatal maternal smoking is
associated with increased occurrence of overweight among children and early adolescents. Such health consequences
may become apparent not only in childhood but also in adulthood. Other chemicals have an impact on intrauterine growth
retardation, low birth weight, and prematurity which are documented as predisposing factors for obesity.
Conclusion. The obesity epidemic should be considered a multifactorial complex disorder. The potential effect of chemicals
on the developmental programming of obesity is great and there are necessary more studies on chemical exposures
during pre- and perinatal development to assess later obesity
Детская раняя эпилептическая энцефалопатия - синдром Ohtahara
Universitatea de Medicină şi Farmacie ”Gr.T.Popa” Iaşi, Clinica a III-a PediatrieThe Ohtahara syndrome is a rare epileptic encephalopathy characterized by tonic seizures with onset in the first days
of life and a typical EEG pattern of ,,suppression burst”. The authors present eight patients diagnosed with Ohtahara
syndrome based on electro-clinical aspects. In all cases the neuro-imaging brain exploring showed major structural brain
abnormalities. The antiepileptic medications could not achieve seizures control in any of the children. The prognosis was
poor, 3 patients died in infancy and the rest had severe motor and mental retardation.Ohtahara синдром является редкой эпилептической энцефалопатиеи и характеризуется тоническими судорогами с началом в первые дни жизни, сопровождается ЭЭГ тип шаблона, „взрыв подавления”. Авторы представляют восемь пациентов с диагнозом синдром Ohtahara на основе электро-клинических аспектов. Изучение
мозга нейровизуализации во всех случаях показало основные аномалия структур мозга. АЭП не смогли добиться контроля над приступами. 3 пациента умерли в младенчестве, а остальные 5 имели тяжелую психомоторную отсталость
Mechanisms of Oncogene Activation
The main modifications that characterize cancer are represented by alterations in oncogenes, tumor-suppressor genes, and non-coding RNA genes. Most of these alterations are somatic and the process is a multistep one. Tumors often arise from an initial transformed cell, and after subsequent genetic alterations different cytogenetically clones lead to tumor heterogeneity
Соображения, касающиеся менеджмента медицинских услуг больным сахарным диабетом
Chronic disease transformed the patient-doctor relationship into a long-term one ensuring the continuity of healthcare. The questionnaire PACIC (Patient Assessment of Chronic Illness Care) has the aim to measure the structuring of provided healthcare. We will present the Romanian version of PACIC, which is now in the phase of pre-testing and cognitive interviewing.Хроническое заболевание превратило отношение врач – пациент в долгосрочные отношения, обеспечивая непрерывность медицинской помощи. Целью анкеты PACIC (Patient Assessment of Chronic Illness Care – Оценка пациентом медицинских услуг при хроническом заболевании) является определение степени структурирования оказываемых медицинских услуг. В нашем исследовании мы представляем разработанный на румынском языке вариант, который в настоящее время находится на этапе предварительного испытания и когнитивного интервью
LIVER DISEASE IN CHILDREN WITH CYSTIC FIBROSIS
Liver disease is an early complication in children with cystic fi brosis (CF).The clinical manifestations in hepatobiliary disease of CF include neonatal cholestasis, liver steatosis, liver fi brosis, biliary lithiasis, focal biliary cirrhosis and multilobular cirrhosis, with or without portal hypertension. Changes in the tests evaluating the liver
function are inconsistent and are not correlated with the severity of the liver lesions. The diagnosis of liver disease in CF requires the presence of at least two of the following four diagnosis criteria:clinical manifestations,
pathologic liver function tests, ultrasound and histologic changes.The annual follow-up to evaluate the liver
function is s recommended for diagnosis of asymptomatic liver disease and early initiation of treatment with
ursodeoxycholic acid.The improvement of the liver function infl uences life quality and increases the survival rate in patients with CF
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