Baseline characteristics in British women and men aged 60–79 years without cardiovascular disease by categories of hypertension amongst men. N = 3042.

<p>In this table results are only presented for those with complete data, and for those with non-missing hypertensive status; HT = Hypertensive.</p><p>*i.e. the p-value tests whether the distribution differs between any of the groups and has 3 degrees of freedom.</p><p>**For these variables geometric means and 95% confidence intervals are presented.</p>$<p>Using robust standard errors to account for differences in variances between groups.</p>$$<p>Manual social class defined as social class III manual/class IV/class V/armed forces.</p>†<p>Included as categorical covariable with all levels (never/ex/current smoker, all levels of social class) in analysis.</p><p>***Response not required if not on drugs.</p

Association of hypertension categories with CVD mortality in women and men combined.

<p>*Model 1: adjusted for sex, age (as time variable in Cox model).</p><p>Model 2: additionally adjusted for BMI, smoking, physical activity, LDL cholesterol, HDL cholesterol, triglycerides (log scale), glucose (log scale), insulin (log scale), fathers occupational social class (childhood social class), own adult occupational social class.</p><p>Model 3: additionally adjusted for systolic and diastolic blood pressure (BP).</p><p>**Imputed numbers per group and associated numbers of events are means over 20 imputed datasets.</p><p>Numbers per group differ slightly between <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0017792#pone-0017792-t002" target="_blank">Tables 2</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0017792#pone-0017792-t003" target="_blank">3</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0017792#pone-0017792-t004" target="_blank">4</a> as time to event and the censoring variable are included as a covariable in the imputation prediction model.</p

Association of hypertension categories with all-cause mortality in women and men combined.

<p>*Model 1: adjusted for sex, age (as time variable in Cox model).</p><p>Model 2: additionally adjusted for BMI, smoking, physical activity, LDL cholesterol, HDL cholesterol, triglycerides (log scale), glucose (log scale), insulin (log scale), fathers occupational social class (childhood social class), own adult occupational social class.</p><p>Model 3: additionally adjusted for systolic and diastolic blood pressure (BP).</p><p>**Imputed numbers per group and associated numbers of events are means over 20 imputed datasets.</p><p>Numbers per group differ slightly between <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0017792#pone-0017792-t002" target="_blank">Tables 2</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0017792#pone-0017792-t003" target="_blank">3</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0017792#pone-0017792-t004" target="_blank">4</a> as time to event and the censoring variable are included as a covariable in the imputation prediction model.</p

Association of hypertension categories with fatal and non-fatal CVD in women and men combined.

<p>*Model 1: adjusted for sex, age (as time variable in Cox model).</p><p>Model 2: additionally adjusted for BMI, smoking, physical activity, LDL cholesterol, HDL cholesterol, triglycerides (log scale), glucose (log scale), insulin (log scale), fathers occupational social class (childhood social class), own adult occupational social class.</p><p>Model 3: additionally adjusted for systolic and diastolic blood pressure (BP).</p><p>**Imputed numbers per group and associated numbers of events are means over 20 imputed datasets.</p><p>Numbers per group differ slightly between <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0017792#pone-0017792-t002" target="_blank">Tables 2</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0017792#pone-0017792-t003" target="_blank">3</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0017792#pone-0017792-t004" target="_blank">4</a> as time to event and the censoring variable are included as a covariable in the imputation prediction model.</p

Baseline characteristics in British women and men aged 60–79 years without cardiovascular disease by categories of hypertension amongst women. N = 3182.

<p>In this table results are only presented for those with complete data, and for those with non-missing hypertensive status; HT = Hypertensive.</p><p>*i.e. the p-value tests whether the distribution differs between any of the groups and has 3 degrees of freedom.</p><p>**For these variables geometric means and 95% confidence intervals are presented.</p>$<p>Using robust standard errors to account for differences in variances between groups.</p>$$<p>Manual social class defined as social class III manual/class IV/class V/armed forces.</p>†<p>Included as categorical covariable with all levels (never/ex/current smoker, all levels of social class) in analysis.</p><p>***Response not required if not on drugs.</p

Prevalence of COPD adjusted for age and stratified by smoking status.

<p>Prevalence of COPD adjusted for age and stratified by smoking status.</p

Survival curves for the lowest and highest index of multiple deprivation categories, adjusted for age, for overall and cause-specific mortality in the BWHHS, 1999-2001 to 2012.

<p>(a) All-cause, (b) all vascular, (c) all cancer, (d) all respiratory disease and (e) others. The Y-axes were truncated to 0.6 for a better visualization. The dashed lines divide the graphs into periods of four years.</p

Age-adjusted hazard ratio (95%CI) for overall mortality across categories of index of multiple deprivation.

<p>The vertical axis is plotted in the log-scale. The distances between categories in the horizontal axis correspond to the mean values for index of multiple deprivation (IMD) in England. IMD categories were based on the standard deviation (SD) from the overall score from each country (SD by country: England= 15.7, Wales= 14.3 and Scotland= 16.6). Numbers above each box indicate the corresponding hazard ratios and 95% confidence intervals. The mean and the range were calculated from the overall score from each country by IMD categories.</p

Information on genotyped and imputed SNPs.

*<p>The WHII study was typed at two centres with different array readers, which were compared and shown to be concordant.</p

Disease event definitions, incident and prevalent events by disease and medication use in the UCLEB consortium.

<p>Total incident CHD =  incident non-fatal MI or revascularization plus fatal CHD (ICD codes I20–I25, I516).</p><p>Total prevalent CHD  =  prevalent non-fatal MI or revascularization.</p><p>Total incident stroke  =  incident non-fatal stroke (ischaemic & haemorrhagic combined, but excluding TIA) plus fatal stroke (ICD codes I60×, I61×, I62, I629 I63×, I64× I65× I66×, I67, I672, I678, I679, I69×, G46×, G450, G451, G452, G453).</p><p>Total diabetes defined by a combination of self-report, medical history review, use of glucose lowering medication, or fasting glucose >7 mmol/L.</p>*<p>1958BC are currently undertaking case ascertainment.</p