Children's demographic characteristics, medicine type and ADR information.

1<p>Age reported in year groups: 0–2; 3–5; 6–11; 12 years and over.</p>2<p>Calculated using Lower Super Output Area (LSOA) 2007 ranked score data, whereby lower scores indicate greater deprivation (data for families outside England are not reported due to incompatibility between IMD scoring systems within UK).</p>3<p>Severity scores were assessed using the Hartwig scale <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0046022#pone.0046022-Hartwig1" target="_blank">[84]</a> where 1 = No change in treatment with suspected drug; 2 = Drug dosing or frequency changed, without antidote or treatment for exhibited symptoms; 3 = Required treatment, or drug administration discontinued; 4 = Resulted in patient transfer to higher level of care; 5 = Caused permanent harm to patient or significant haemodynamic instability; 6 = Directly or indirectly resulted in patient death.</p

Flow chart of the development of the Liverpool ADR avoidability assesmsent tool.

<p>Flow chart of the development of the Liverpool ADR avoidability assesmsent tool.</p

Breakdown of percentage agreement and extreme disagreement between specialties.

<p>Breakdown of percentage agreement and extreme disagreement between specialties.</p

The Liverpool ADR avoidability assessment tool (LAAT).

<p>The Liverpool ADR avoidability assessment tool (LAAT).</p

Hallas and the modified Hallas scale.

<p>Hallas and the modified Hallas scale.</p

Number of ADRs per patient with ≥ one ADR according to origin of prescription.

<p>Number of ADRs per patient with ≥ one ADR according to origin of prescription.</p

Classification of drugs associated with ADR admissions.

<p>Classification of drugs associated with ADR admissions.</p

Univariate analyses of ADRs by age.

<p>Univariate analyses of ADRs by age.</p

Univariate analyses of ADRs by number of medicines taken.

<p>Univariate analyses of ADRs by number of medicines taken.</p

Possibly and definitely avoidable cases and explanation of assessment result.

<p>Possibly and definitely avoidable cases and explanation of assessment result.</p