Postsurgical Rehabilitation of a Rotator Cuff Tear

The purpose of this project is to determine a rehab protocol for a postsurgical rotator cuff tear. The structure under investigation is a newly repaired torn rotator cuff, that is in a very delicate state and will require treatment and rehabilitation immediately following surgery. Rehabilitation will continue until the rotator cuff has completely healed, and range of motion, strength, and stability have been restored to the glenohumeral joint

Progress towards accessing a C3v [6,6] nanotube end-cap and development of a microwave assisted anionic cyclodehydrogenation reaction

Thesis advisor: Lawrence T. ScottThis dissertation describes the work that has been carried out towards accessing a C3v [6,6] nanotube end-cap through rational chemical synthesis. Continued advancement in carbon nanotube research has driven scientists to develop a successful route to usable quantities of nanotubes that are homogeneous in structure. Due to the current inability to separate nanotube mixtures efficiently, researchers in fields ranging from chemistry to computer science have been unable to exploit fully all that these unique molecules have to offer. Our envisioned approach to this obstacle involves elongation of a template endcap using iterative growth chemistry. The final stage of the proposed end-cap synthesis involves the execution of a six fold cyclodehydrogenation reaction. To carry out this desired transformation, a new microwave assisted variant of the anionic cyclodehydrogenation reaction has been developed. Through this chemistry we have been able to access a variety of both known and novel polycyclic aromatic hydrocarbons, often in impressively high yields. We hope that this chemistry will be useful to us in accessing the target nanotube end-caps, and to others in providing a new route to accessing a variety of polycyclic aromatic hydrocarbon cores.Thesis (PhD) — Boston College, 2008.Submitted to: Boston College. Graduate School of Arts and Sciences.Discipline: Chemistry

The English Novel, 1800–1829 & 1830–1836: Update 7 (August 2009–July 2020)

This report, like its predecessors, relates primarily to the second volume of The English Novel, 1770–1829: A Bibliographical Survey of Prose Fiction Published in the British Isles (Oxford: OUP, 2000) [EN2], co-edited by Peter Garside and Rainer Schöwerling, with the assistance of Christopher Skelton-Foord and Karin Wünsche. It also refers to the online The English Novel, 1830–36: A Bibliographical Survey of Fiction Published in the British Isles [EN3], which effectively serves as a continuation of the printed Bibliography

The English novel, 1800–1829 & 1830–1836: update 8 (April 2000–June 2023)

This report, like its predecessors, relates primarily to the 2nd vol. of The English Novel, 1770–1829: A Bibliographical Survey of Prose Fiction published in the British Isles (2000) and the online The English Novel 1830–1836. The procedure followed derives generally from the activities of the research team who helped produce The British Novel 1800–1829: A Database of Production, Circulation, and Reception, first made publicly available in 2004, though only materials found in Updates 1–4 are incorporated in that database. The present report comes twenty-three years since the release in March 2000 of the printed Bibliography, and some nineteen years after the original launch of British Fiction 1800–1829 database. Its primary aim is to consolidate all the preceding seven Updates into one final composite statement, while at the same time, in assembling these materials, reference has been made to a number of additional sources, incorporating further new information

Assessing a Pilot Scheme of Intensive Support and Assertive Linkage in Levels of Engagement, Retention, and Recovery Capital for people in Recovery Housing using Quasi-Experimental Methods

Introduction: There is strong and ever-growing evidence highlighting the effectiveness of recovery housing to support and sustain substance use disorder (SUD) recovery augmented by intensive support comprising assertive linkages to community services.Aim: To assess a pilot intensive recovery support (IRS) intervention for individuals (n=175) entering certified Level II and III recovery residences who met at least three out of five conditions (no health insurance; no driving license; substance use in the last 14 days; currently unemployed; having less than $75 capital) and its impact on engagement, retention and changes in recovery capital for individuals compared with a business-as-usual Standard Recovery Support (SRS) approach (n=1,758).Methods: We deployed quasi-experimental techniques to create weighted and balanced counterfactual groups derived from the Recovery Capital (REC-CAP) assessment tool to compare outcomes for people receiving the pilot IRS compared to intervention against SRS.Results: After reweighting for resident demographics, service needs, and barriers to recovery, those receiving IRS exhibited improved retention rates, reduced likelihood of disengagement, and growth in recovery capital after living in the residence for 6-9 months.Conclusion: Our findings from this pilot intervention suggest that intensive recovery support incorporating assertive community linkages and enhanced recovery coaching can improve engagement, length of stay and recovery capital growth compared to a balanced counterfactual group. We suggest that this model may be particularly beneficial to those entering Level II and Level III recovery housing with lower levels of recovery capital at admission entry.<br/

Measuring moral distress and moral injury:A systematic review and content analysis of existing scales

BACKGROUND: Moral distress (MD) and moral injury (MI) are related constructs describing the negative consequences of morally challenging stressors. Despite growing support for the clinical relevance of these constructs, ongoing challenges regarding measurement quality risk limiting research and clinical advances. This study summarizes the nature, quality, and utility of existing MD and MI scales, and provides recommendations for future use.METHOD: We identified psychometric studies describing the development or validation of MD or MI scales and extracted information on methodological and psychometric qualities. Content analyses identified specific outcomes measured by each scale.RESULTS: We reviewed 77 studies representing 42 unique scales. The quality of psychometric approaches varied greatly across studies, and most failed to examine convergent and divergent validity. Content analyses indicated most scales measure exposures to potential moral stressors and outcomes together, with relatively few measuring only exposures (n = 3) or outcomes (n = 7). Scales using the term MD typically assess general distress. Scales using the term MI typically assess several specific outcomes.CONCLUSIONS: Results show how the terms MD and MI are applied in research. Several scales were identified as appropriate for research and clinical use. Recommendations for the application, development, and validation of MD and MI scales are provided.</p

Drug discovery in advanced prostate cancer: translating biology into therapy.

Castration-resistant prostate cancer (CRPC) is associated with a poor prognosis and poses considerable therapeutic challenges. Recent genetic and technological advances have provided insights into prostate cancer biology and have enabled the identification of novel drug targets and potent molecularly targeted therapeutics for this disease. In this article, we review recent advances in prostate cancer target identification for drug discovery and discuss their promise and associated challenges. We review the evolving therapeutic landscape of CRPC and discuss issues associated with precision medicine as well as challenges encountered with immunotherapy for this disease. Finally, we envision the future management of CRPC, highlighting the use of circulating biomarkers and modern clinical trial designs