8 research outputs found
Compatibility studies of Olanzapine pre-formulated with excipients by thermal analysis: preliminary study
Thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) were used to investigate drug-excipient interactions and, in consequence, their compatibility. For this purpose, binary mixtures of olanzapine drug substance and the excipients croscarmellose sodium, magnesium stearate and microcrystalline cellulose, were prepared and analysed. By the analysis of the binary mixtures DSC and TG curves it were observed changes on the temperature and enthalpy values of the drug melting and decomposition peak, with the likely formation of intermediate substances.Colegio de Farmac茅uticos de la Provincia de Buenos Aire
Fixed and volatile constituents oF genus Croton plants: C. adenoCalyx Baill -euphorBiaceae
aBstract This work describes the phytochemical analysis of Croton adenocalyx Baill (Euphorbiaceae), a plant that is representative of the species from Cear谩 State (Brazil). The GC-MS analysis of the essential oil, obtained by hydrodistillation of the leaves from C. adenocalyx, allowed the identification of eleven volatile constituents; the main components were identified as 伪-pinene (32.63%); bicyclogermacrene (13.96%); trans-caryophyllene (10.23%); germacrene D (10.14%); 尾-pinene (10.11%) and 尾-elemene (8.31%). The chromatographic purification of the ethanolic extract from the trunk bark, allowed the isolation and identification of the 6-methoxy-7-hydroxycoumarin (1) and 3麓,5-dihydroxy-3,4麓,7-trimethoxyflavone (2). Keywords: Euphorbiaceae, Croton adenocalyx, Essential oil, GC-MS, Flavonoid, Coumarin. resumen Este trabajo describe el an谩lisis fitoqu铆mico de Croton adenocalyx Baill (Euphorbiaceae), una planta representativa de las especies del Estado de Cear谩-Brasil. El an谩lisis por CG-EM del aceite esencial, obtenido por hidrodestilaci贸n de las hojas de C. adenocalyx Baill, permiti贸 la identificaci贸n de diez constituyentes vol谩tiles. Los componentes mayoritarios fueron identificados como 伪-pineno (32.63%), biciclogermacreno (13.96%), trans-cariofileno (10.23%), germacreno D (10.14%), 尾-pineno (10.11%) y 尾-elemeno (8.31%). La purificaci贸n cromatogr谩fica del extracto etan贸lico de la corteza del tronco, permiti贸 aislar e identificar la coumarina 6-metoxi-7-hidroxicumarina (1) y el 3麓,5-dihidroxi-3,4麓,7-trimetoxiflavona (2)
Compatibility studies of Olanzapine pre-formulated with excipients by thermal analysis: preliminary study
Thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) were used to investigate drug-excipient interactions and, in consequence, their compatibility. For this purpose, binary mixtures of olanzapine drug substance and the excipients croscarmellose sodium, magnesium stearate and microcrystalline cellulose, were prepared and analysed. By the analysis of the binary mixtures DSC and TG curves it were observed changes on the temperature and enthalpy values of the drug melting and decomposition peak, with the likely formation of intermediate substances.Colegio de Farmac茅uticos de la Provincia de Buenos Aire
Extraction and evaluation of fatty acid compositon of Orbignyaphalerata martius oils (arecaceae) from Maranh茫o State, Brazil
Mikania glomerata
The present study primarily aims to identify the relative density and the fatty acids (methyl esters) content present in the standardized ethanol extract of leaves of M. glomerata (EPMG). Meanwhile, in a second moment, this study evaluated the effects of the EPMG on the levels of amino acids in the hippocampus, and the mechanism of sedative and anxiolytic action. Adult mice were treated with doses of 200, 300, and 400鈥塵g/kg and evaluated in open field, elevated plus-maze, light dark, and rotarod tests. Moreover, in the behavioral tests diazepam (GABAergic anxiolytic, 2鈥塵g/kg) as positive control and flumazenil (GABA antagonist, 2.5鈥塵g/kg) were used to identify mechanism of sedative and anxiolytic action produced by EPMG. The EPMG is constituted by the following compounds: methyl cinnamate, 2H-1-benzopyran-2-one, (2-hydroxyphenyl)methyl propionate, (Z)-methyl-hexadec-7-enoate, methyl hexadecanoate, hexadecanoic acid, (Z)-methyl-octadec-9-enoate, octadecanoic acid, and squalene. This extract demonstrated anxiolytic effects, which may be mediated by GABAergic system, and was able to increase GABA levels and reduce of glutamate and aspartate concentrations in mice hippocampus, which can directly and/or indirectly assist in their anxiolytic effect. Although more studies are needed, the EPMG could represent an interesting therapeutical strategy in the treatment of anxiety